Excerpts

Differences were regarded as statistically significant and as statistically highly significant if p values were <0.05, and p < 0.001, respectively.

P < 0.05 were considered as statistically significant and labeled as *, while ** represents P < 0.01 (highly significant), and *** represents P < 0.001 (very highly significant), respectively.

However, as reported, most statistical tests on CHIT1 + cells yielded highly significant results ( P ≤ 0.001) after correction for multiple testing.

By using linear mixed model analyses testing for genetic variation among accessions, and by estimating the impact of the TM treatment on biomass accumulation compared to the respective mock control, we detected a highly significant accession-by-treatment interaction ( P < 0.001), highlighting natural variation in the accumulation of biomass of the accessions in response to chronic ER stress.

In contrast, the overlap between hTau 421D and Rab7 compartments was highly significant ( p < 0.001).

We find that the increase in tubule density in the presence of dimerizer is highly significant ( p < 0.001), and there is a strong trend toward increased tubule complexity ( p = 0.09).

Statistical analysis was performed using the Student’s t -test with statistical significance assigned at * P < 0.05 (significant), ** P < 0.01 (moderately significant), *** P < 0.001 (highly significant), and **** P < 0.0001 (extremely significant).

p < 0.05 was considered statistically significant, very significant if 0.001 <p < 0.01 and extremely significant if p < 0.001.

p < 0.05 was considered statistically significant, very significant if 0.001 < p < 0.01 and extremely significant if p < 0.001.

18 showed a highly significant difference in ldPHI and zldPhi scores between our sorted VTE and non-VTE trials (Mann–Whitney Rank sum test, p < 0.001).

The results of the present study revealed an increasing trend in juniper growth with decreasing sea ice extent ( r = −0.59, 1901–2015, p < 0.001), particularly during notable recurrent periods of significant ice cover increases in 1907, 1935–1936, 1983–1984 and 2008, resulting in low growth.

P values were considered as significant (*) if P <0.05, as very significant (**) if P <0.01 and as extremely significant (***) if P <0.001.

The inversion also showed a sex-specific effect on the duration of the larval stage, with no significant difference among female genotypes (on average, αα: 9.0 days, αβ: 8.7 days, ββ: 9.0 days; glmm p = 0.57) but highly significant differences among males (glmm p < 0.001, Fig. 2b Supplementary Table 5 , Supplementary Fig. 3 ).

Fisher’s exact test demonstrated a highly significant overlap of 1229 genes between eccDNA-associated and ZGA gene sets ( P value < 0.001; Supplementary Fig. 1B , right), which was not observed in random controls (Supplementary Fig. 1C ).

However, both genes are highly significant (p < 0.001, with log2FC values of 2.33 and 2.7, respectively) in SHGS+ versus SHGS- hepatocytes.

The significance thresholds were deemed as statistically significant ( P ≤0.05), highly significant ( P ≤0.01) or extremely significant ( P ≤0.001).

Similarly, GPP max_EC-LUE also followed the same pattern with NDVI max , showing an increasing trend from 1982 to 2018 at a rate of 1.13 ± 0.12 × 10 −2 g C m −2 d −1 yr −1 (t (35) = 9.67, P < 0.001, 95% CI [0.89 × 10 −2 , 1.36 × 10 −2 ]), but declining during the 1998-2009 period at a rate of −0.51 ± 0.29 × 10 −2 g C m −2 d −1 yr −1 (t (10) = −1.77, P = 0.11, 95% CI [−1.14 × 10 −2 , 0.13 × 10 −2 ], Supplementary Fig. 2c ).

In fact, the negative R between W and SPEI over 22-year sliding windows showed a decreasing trend of −0.015 yr -1 ( p < 0.001 with a t -test; Fig. 1b ) from 1951–1972 ( R = −0.40, p > 0.05 with a t -test) to 1989–2010 ( R = −0.66, p < 0.001 with a t -test).

In immortalized lymphocytes from human blood samples ( Supplementary Table 1 ), we observed a highly significant correlation between ARHGAP33 and SORT1 expression levels ( Fig. 7d ; r =0.42, P <0.001), suggesting that common cellular mechanisms regulate the expression of ARHGAP33 and SORT1 .

Statistical analysis was performed using the one way/two-way ANOVA or the Student’s t-test with statistical significance assigned at *** P < 0.05 (significant), ** P < 0.01 (moderately significant), *** P < 0.001 (highly significant) and **** P < 0.0001 (extremely significant).

3c and Supplementary Data 5 ) relative to Wilms tumours, analysis using GSEA and the Database for Annotation, Visualization and Integrated Discovery (DAVID) 27 , 28 toolset also revealed a highly significant enrichment for homeobox proteins (FWER P <0.001; Supplementary Fig. 7 ) and upregulation of distinct classes of homeobox proteins, which are the canonical targets of polycomb-mediated repression.

Interestingly, pairing with different minPs had highly significant effects on both the promoter and enhancer activities of tested elements (Promoter activity, F(2, 8301) = 457.7, P -value < 0.001, ANOVA; Enhancer activity, F(2, 8296) = 309.5, P -value < 0.001; Fig. 6a, b).

The quantitative data confirmed the previous qualitative observation in revealing a highly significant increased incidence of Type 1 cells in Cyfip1 +/− (LME: χ 2 (1) = 68.49, p < 0.001, Fig. 4c ).

These tests were considered not significant when p ≥ 0.05 (ns), significant when 0.01 ≤ p < 0.05 (*), very significant when 0.001 ≤ p < 0.01 (**), and extremely significant when 0.0001 ≤ p < 0.001 (***) or when p < 0.0001 (****).

This test reports a highly significant agreement ( p < 0.001) between experimental and simulated retroviral integration profiles in folded substrates and it confirms that there is no correlation ( p ≃ 0.6) between experimental profiles and the ones found along unfolded chromatin substrates.