The overall firing rate correlations with trial outcomes increased after outcome onset and was stronger in the Guanfacine than vehicle condition in dlPFC, striatum and with a statistical trend in the ACC (Fig. 3A ; permutation test, dlPFC: p < 0.05 during 0.5–0.6s; striatum: p < 0.05 during 0.05–0.3s; ACC: p < 0.075 during 0.4–0.45s).
Excerpts
To determine CNV enrichment, we only considered loci that were nominally significant between the comparative groups ( P < 0.05).
Of the 75 SNPs found in whites, 34 (46%) were nominally significant at P < 0.05 in Japanese, with 18 at P < 0.0005.
About 74.2% of the land surface shows an increasing trend, among which 52.7% is significant at p = 0.05 level (two-tailed).
The dust-induced RF in SSP126 shows a slightly increasing trend ( p < 0.05 from the MK test) that switches to a slightly decreasing trend ( p < 0.05 from the MK test) if future dust deposition remains at the historical value (Fig.
Nominally significant effects of diagnosis on AIs (i.e., with P < 0.05, but which did not survive multiple comparison correction), were observed for the fusiform surface area AI ( β = −0.005, t = −2.56, P = 0.010) (Supplementary Table 2 ), pars orbitalis thickness AI ( β = −0.003, t = −2.26, P = 0.024), posterior cingulate thickness AI ( β = −0.003, t = −2.1, P = 0.034), superior temporal thickness ( β = −0.002, t = −1.97, P = 0.049), and caudate nucleus volume ( β = 0.003, t = 2.24, P = 0.025).
Among these 38 genes, 13 replicated at a Bonferroni significance level (Logistic Regression p < 0.0013) with directions of effect consistent with the discovery findings in a cohort of unrelated, non-Hispanic white Kaiser Permanente health plan members (6653 PrCa cases, 30,121 controls), and an additional six were nominally significant ( p < 0.05; Table 1 ).
For all nominally significant associations ( p < 0.05), effect sizes were strongly correlated when using imputed vs.
Among female-specific fertility traits, LDSC identified nominally significant ( P < 0.05) r g between increased MPB severity and fewer number of live births ( r g = −0.06, SE = 0.02) and increased age of first birth ( r g = 0.04, SE = 0.02) (Table 1 ), suggesting shared genetic risk.
When the BA or the SPEI time series exhibit a significant trend (i.e., p -value <0.05, assessed with the Mann–Kendall test), we fit the model including the predictor time T .
ClinVar data were downloaded as VCF (accessed 02.05.2022) and filtered for nominally significant single variants ( P < 0.05 in any phenotype model).
eQTL analysis of the remaining 26 loci (69 protein-coding genes) identified 22 SNP-gene combinations that were nominally significant ( t -test P < 0.05) in all, ER+ or ER− breast cancers (Supplementary Data 6 ), nine of which remained significant after taking account of multiple testing (FDR adjusted t -test P < 0.1,Table 3 ).
Despite the majority of the cross-phenotype effect sizes being in the same direction (32 out of 34), only half demonstrated a nominally significant association ( P < 0.05).
T/F viruses with incompletely closed Envs were also more sensitive to sCD4, although this difference did not reach statistical significance ( P = 0.05; Supplementary Fig. 3d ); and we observed a significant correlation between cold and sCD4 sensitivity ( P = 0.0005; Fig. 1f ).
After mapping these CpG sites to genes, performing GO enrichment analyses, and removing overlapping GO terms, there were a total 95, 76, and 47 nominally significant (hypergeometric test P < 0.05) biological processes, respectively.
Six of the 27 unconditional (22.2%), and 3 of the 13 conditional (23.1%) SNPs had nominally significant ( P <0.05) heterogeneity, much more than the 5% expected by chance ( Supplementary Dataset 1 , Supplementary Tables 1–3 ).
2 F), we observe a weak trend with the log volume of data per subject (Fig. 2 G, p < 0.05).
These contrasting trends for the two country groups are linked to their respective ISA expansion trends, with the NAI countries having a strong increasing trend over time (320.9 km 2 yr −2 , p < 0.01), which, again, is partly offset by a decreasing trend for the AI countries (−15.4 km 2 yr −2 , p > 0.05).
In total, 63 loci have shown at least marginal significance ( P <0.05) with ER-negative breast cancer.
Out of 34 comparisons, 26 were nominally significant ( p < 0.05), and 22 passed the Bonferroni significance threshold (0.05/34 = 0.00147).
Among 15 associations with more than two instrumental variables (9 metabolites, 7 FinnGen outcomes), seven associations (3 metabolites, 6 outcomes) remained nominally significant ( P -value < 0.05) in MRPRESSO outlier test.
Precise statistics, beyond qualitative indication of significance at P <0.05, are not published in the Tracking Mammals Partnership Update 33 , so any trends were conservatively allocated as marginally significant at 0.01< P <0.05.
Among the pAIDs examined where the SNP- h 2 estimates were at least nominally significant ( P <0.05), T1D and juvenile idiopathic arthritis (JIA) were the most highly heritable ( Fig. 1b ).
Probability values <0.10 but >0.05 (0.10< P <0.05) were considered marginally significant, and values <0.05 ( P <0.05) were considered significant.
Univariate linkage disequilibrium score regression (LDSC) 24 analysis showed nominally significant heritability for all 37 phenotypes ( P < 0.05, Table 1 ).