Excerpts

However, there is a slight trend towards higher transcript expression in baseline tissue of high histological BDI, high biochemical biliary viability livers (Fig. 5a ).

Livers with acceptable bile chemistry showed a trend towards lower levels of histological injury in all categories, although this was only significant for injury to deep PBGs ( p = 0.022, Fig. 2a ).

Consistent with the GO analysis, the differences in the expression of multiple genes in the ECM network, including collagens ( COL1A1, COL1A2, COL3A1, COL4A1 ), fibronectin ( FN1 ), Lumican ( LUM ) and Osteonectin ( SPARC ), are highly significant in vivo compared to in vitro.

The lack of a clear trend in the direction of the estimates for all elevation gradients suggests that, at a local scale, temperature variability might not be the dominant driver of species’ elevation ranges, or has different influences depending on plant community composition.

The strength and continuity in the diurnal temperature range-species’ range size relationship, with a negative trend being visible in both island and continental mountains (Fig. 3 a), suggest that short-term temperature variation plays a major role in driving the observed range-size pattern that cannot be imputed to island-specific factors (e.g. lower competition).

In the kidney, TMV had a clear trend of higher expression of HAS2, although it was not significant due to large variation (Supplementary Fig.

‘Gradually down–regulated’ means a decreasing trend in fold change from the MCI/HC comparison to the AD/HC comparison.

‘Progressively up-regulated’ means an increasing trend in fold change from the MCI/HC comparison to the AD/HC comparison.

6b ) and showed a trend of improved glucose homeostasis, though not reaching statistical significance (Supplementary Fig. 6c ).

The enrichment of reaction products within microreactors is highly significant in synthetic biology as it enhances the local concentration of intermediates, which can improve the efficiency of tandem reactions.

Consequence of selective lesions in ACC When a nested ANOVA [Lesion-group (ACC/Control, between-subject factor) × Monkey (10 monkeys, between-subject factor) nested within Lesion-group] was applied to RT-COV in correct (cC) trials in ACC-lesioned and Control monkeys, there was a highly significant effect of Lesion-group (Table 2a ): the RT-COV was significantly smaller in the ACC-lesioned group (Fig. 2a, b ), which was in contrast to the consequence of lesions (larger RT-COV) in the PCC-lesioned monkeys (Fig. 3e ).

S 1b ), we have mainly considered the conclusion obtained with RT-COV (marginally significant), because both the RT variability and mean RT decreased in this case (see Methods, Data analyses).

Furthermore, Cox proportional hazards model analysis 38 indicated that five of the transcriptomic markers ( STMN1, WDR12, AZIN1, MAD2L1 , and MCM4 ) had a significant association with response to Enzalutamide (Wald p value < 0.05, Supplementary Data 5C , see Methods), yet many of them were borderline significant and did not outperform MYC and NME2 (Supplementary Data 7C ).

We observed a weak trend whereby longer transcripts are better enriched (Fig. 4b and Supplementary Fig. 4c ).

The latter results indicate that while the ecological advantage of genomovars DW07 and CZ05 at high-salt conditions may be significant, it is apparently not strong enough to purge diversity within the species (i.e., completely outcompete remaining genomovars), and genomovars that may be less-adapted to high-salt concentrations (e.g., CZ34 and CM11) appear to survive such (unfavorable) conditions, presumably as (viable) members of the rare biosphere.

Aβ-induced APEL was characterized through a transwell assay, where a range of concentrations (0 μM–40 μM) were employed, before two concentrations, 20 μM and 40 μM, were selected for further experiments due to their highly significant induction of leakiness (Supplementary Fig. 3 ).

We thus performed downstream analyses on the combined tinnitus GWAS meta-analysis, which had a highly significant h 2 SNP = 0.07 (SE = 0.004, on the liability scale).

However, there were two events, one involving aneuploidies and the other involving a homoeologous exchange that, while statistically highly significant and physically very large, could only be explained either by assuming that the individual sequenced underwent a somatic mutation that led to somatic mosaicism for the chromosomal aberration or that the sequenced material derived from at least two genetically heterogeneous individuals differing for the detected aberration.

In the longitudinal samples, IFNγ decreased from diagnosis to the second time point 2 m post diagnosis, TNFα increased, and IL-2 showed a trend for an increase in response to ATB116.

As the difference was not large ( < 13 kJ mol −1 ) and hardly significant, it can be assumed that ammonia decomposition operates via a similar reaction mechanism for iron- and cobalt-monometallic or bimetallic catalysts in line with the literature reporting that the rate-determining step is the nitrogen desorption step on Fe- and Co-based catalysts 24 .

Notably, the vascularity in the S-DTMS group showed a trend of compensatory hyperplasia of the collateral circulation, and branched vessels covering the LV surface, which explaining the higher LVEF and near-normal myocardial tissue structure in the S-DTMS group.

Moreover, the extent of TE reduction in rlmnl3 showed an increasing trend as the number of tandem codons in genes increased (Fig. 7f ).

Nevertheless, a clear trend can be observed in E WO1 to E WO3 (Fig. 2a, c ), suggesting that an inhomogeneous hematite layer alone (Fig. 2f center) is not sufficient for the required high randomness in the electrode resistance.

There were nominally significant interactions in (mostly) frontal cortical regions with the maternal but not the fetal PGS, especially in males, demonstrating that relative to the 1943–1948 birth period, the cohort of individuals born 1955–1960 had weaker associations between the maternal PGS and SA (Fig.

Interestingly, proteins that were decreased in the late disease rNLS8 cortex also showed a trend towards a decrease or down-regulation in the human datasets (Fig. 7b ).