Excerpts

The observed differences in mean slopes and the slope distributions of all periods are statistically highly significant (Supplementary Table 3 ).

No gene had more than one rare, recessive genotype, and no other single gene approached significance in analyzing the burden of rare, damaging alleles in cases.

For example, ensuring connectivity to habitats with higher mean temperature or temperature variation can promote an influx of species or genotypes that can cope with an increasing trend in temperature by maintaining the local trait variation of temperature optima.

9 ; see the “Methods” section), we observed a clear trend in which conserved COPs generally have higher AUCs across molecular features than tissue-specific or unique COPs (Supplementary Fig. 10 ).

Furthermore, in Arabidopsis , cis -(+)-12-oxo phytodienoic acid (OPDA) and 10-oxo dinor -phytodienoic acid ( dn )-OPDA were not significantly affected and even showed a trend of increase at warm temperature like the expression of the regulatory enzymes (Supplementary Fig. 15a, b ).

Assessment of common myeloid progenitors (CMPs) and granulocyte/macrophage progenitors (GMPs) in juvenile offspring, showed a trend towards increased frequencies in offspring born to IAV-infected mothers, respectively (Fig. 4d, e ).

During early phase (0–4 hpi), since a small number of genes were marginally significant, genes with q < 0.1 and |log 2 (expression fold change)| > 1.5 were determined as DEGs.

Please note that trigram token frequency co-varied greatly with word frequency, which could explain the marginal significance.

The nC3 cluster, however, shared a marginally significant number of specific-signature genes with cycling populations in the human fetal gland (i.e., cycling sympathoblast and chromaffin, FDR < 0.05, Fisher’s exact test, Fig. 5e ).

All of these differences were highly significant.

A notable trend of lower HIV-1 Gag transcripts was observed in both tissues in ZPAMt exosome-treated mice (Supplementary Fig. 7a, b ).

However, such a high value of P CR / P th is at odds with the picture of turbulent acceleration, and the feedback from CRs to MHD turbulence may be significant.

Correlations for MS with IBD, UC and CD in peripheral blood mononuclear cells (PBMC) were also high (~0.6), but only marginally significant due to the modest number of cell types in this tissue ( N = 11).

Across the 46 genes identified by revTWMR, we observed a clear trend for functional relevance.

pneumoniae strains NTUH-K2044 or BJ1-GA as prey, the encapsulated Klebsiella strains (CPS+) survived at comparable levels in the presence of the T6SS-positive and T6SS-deficient competitors, while the non-encapsulated (CPS−) derivatives showed a highly significant survival defect when they encountered T6SS-positive attackers.

GO annotation enrichment analysis confirmed that protein localisation (GO:0008104~protein localisation) and transport (GO:0015031~protein transport) are highly significant functional processes for this group of 253 relocalising proteins (see Supplementary Data 11 ).

This may be significant for patient health, epidemiology, and diagnosis.

1b, c ), with reduced erythrocytes and elevated monocyte proportions in the blood, and highly significant thrombocytopenia (Fig. 1d–f ).

Our finding of a lack of significant interactions between the highly significant local temperature and land use contrasts in part with the previously reported strong effects resulting from the interaction between land use and climate along the elevational gradient of the Kilimanjaro.

Determination method for global solute-induced river syndromes Three solute-induced river syndromes were identified following Meybeck’s classification 51 for different solute trends: salinization with Σ + (Σ + = C Ca 2+ + C Mg 2+ + C Na + + C K + ) > 24 meq/L indicating an increasing trend, mineralization with Σ + > 3 meq/L indicating an increasing trend, and desalinization with Σ + < 1.5 meq/L indicating a decreasing trend.

5c , genes related to extracellular matrix ( Col4a1, Col5a3, Col6a1, Col4a2 ) are characterized by a highly significant oscillatory profile with a −log( P -value) up to 5.5 with phase peak aligned with the resting phase.

In the comprehensive GHG mitigation scenario that further accounts for non-CO 2 abatement measures, non-CO 2 emissions show a decreasing trend, reducing to 9.8 Gt CO 2 -eq yr −1 in 2100.

Several additional serine proteases, HTRA3 (high-temperature requirement A serine peptidase 3), DPP7 (dipeptidyl-peptidase 7), FAP (fibroblast activation protein alpha), were upregulated in human scars (Figure S6 ), and also showed a trend in mouse scars.

Quantile-quantile plots of observed versus expected P values (minor allele frequency (MAF) >0.01) for all AML cases and cytogenetically normal AML cases showed minimal inflation of test statistics across all three GWAS after adjustment for nominally significant principal components in each GWAS ( λ GC = 1.021, 1.025, and 1.055 for all AML in GWAS1, GWAS2, and GWAS3, respectively; λ GC = 1.006, 1.011, and 1.025 for cytogenetically normal in GWAS1, GWAS2, and GWAS3, respectively) (Supplementary Figs. 6 – 7 ), minimizing the possibility of hidden population stratification and cryptic relatedness.

The results also suggested a decreasing trend in the sensitivity of almost all parameters from the L3 to the L1, except the nuclear degradation, indicating that the WUS nuclear level in the L3 is more sensitive to most of the biological processes studied.