Excerpts

The resource endowment displayed a decreasing trend, primarily due to human activities and extreme weather events, leading to a shrinkage in the spatial distribution of coastal blue carbon ecosystems 21 , 25 , 26 and a deterioration in ecosystem health 27 , 28 .

Including these events, therefore, likely falsely inflates the number of lakes that had a significant trend in timing over time.

In general, the endogenous GA content in both H12 and Gmilpa1-2 plants showed a decreasing trend under white light supplemented with UV-B (Fig. 5e–j ), which demonstrated that UV-B reduced the GA level in soybean.

3a , show a clear trend indicating that the photothermal synthesis requires lower temperatures to achieve nucleation and produce similar-sized nanoparticles (Supplementary Fig. 29 ).

The overall results showed a weak trend of decreased stained surface in group 17 compared to 11.

Quantitative image analysis results showed a trend of decreased stained surface in group 17 compared to 11 (Fig. 6a ).

Figure 3a showed a trend of increased pesticide release with temperature.

We note that the correlation drops to r = 0.53 ( p < 0.001) when 2022 is excluded but remains highly significant.

The comparison between all state-transition classifiers reveals a clear trend of decreasing accuracies with an increasing number of states and increasing accuracy with an increasing number of available channels.

Interestingly, both Anzali and Haraz basins, which had the lowest recharge ratio, were the only basins that demonstrated a decreasing trend in groundwater electrical conductivity during the study period 8 .

7a, b , the levels of each of four measurable oxyl-cardiolipins as well as total oxyl-cardiolipins were significantly higher in Lcn2 KO mice in the basal condition and had an increasing trend in the CL316, 243-treated condition.

Serum-free fatty acid levels had a decreasing trend in WT mice by CL316, 243, but no change in Lcn2 KO mice (Supplementary Fig. 1g ).

A molecular replacement search with the kcTRP5b.1 model yielded a highly significant solution; subsequent refinement and iterative model building revealed good agreement between the design and crystal structure across the core alpha helices (Fig. 6a ), but divergence in two of the four repeat-repeat loop connections (Fig. 6b and Supplementary Fig. 10a ) leading to a globally dissimilar topology.

In addition, the data obtained from the two non-TAG loci again reflect an overall trend that the frequencies of delinver mutations are positively correlated (R 2 = 0.977) with those of deletion mutations but not with the deletion sizes (Fig. 6e, f ).

These differences in within-year-location prediction correlations between the random effects and SNP + EC models were highly significant for 10F-CV.

1 predicts a decreasing trend for the density of charged species in the afterglow with increasing distance from the bulk plasma.

In addition to early tau markers, the more advanced stage marker pThr231-tau (antibody AT180) was also elevated, and the late stage marker pSer202/Thr205-tau (antibody AT8) showed an elevated trend in J20;GT (Supplementary Fig. 8b ).

REST overexpression had a highly significant effect on Aβ deposition in the hippocampus, reducing Aβ plaque burden by 63% (Fig. 9h, i ).

Although statistically barely significant, this could be attributed to a reduced opacity of the nightside atmosphere, i.e., the brightness temperature is determined by a lower atmospheric layer with slightly higher temperature.

In contrast, the association between rs4988235 and BMI remained weakly significant after adjustment for both genome-wide and locus-specific ancestry (Fig. 6C and Supplementary Data 8 ).

3 h–m) with significance or trend toward significance; these HSP47 gene expression changes were not observed in other tissues, including liver, heart, and pancreas tissue (Supplementary Fig. 4a –l).

While more patients experienced dostarlimab-related AEs (71%) than pembrolizumab-related AEs (57%), a numerical trend favoring dostarlimab was observed in the proportion of patients experiencing immune-related adverse events (irAEs) (31% for dostarlimab plus chemotherapy and 39% for pembrolizumab plus chemotherapy), serious adverse events (SAEs) (41% and 48%, respectively), AEs leading to treatment discontinuation (29% and 38%, respectively), and AEs leading to immunotherapy discontinuation (17% and 24%, respectively) (Table 5 ).

We investigated this by a simple and interpretable orthogonal analysis, calculating the number of cell lines crossing a nominally significant RRA < 0.05 for each drug (Fig. 2b and Supplementary Data Fig. 2e ) and for each cell line (Fig. 2c and Supplementary Data Fig. 2f ).

We used t-SNE 28 and UMAP 29 to cluster the data, revealing an interesting trend, with the data primarily clustered by cell line, rather than by drug or outgroup status (Fig. 2a ; Supplementary Data Fig. 2a–d ; UMAP parameters were selected using an automated Monte Carlo approach, see Methods).

Interestingly, the #3 mouse with HBsAg seroconversion showed a trend to have high IL-23, IFN-γ, IL12p70, IL-1β, IL-6, IL-17a and GM-CSF.