Excerpts

Within the ATX group, we observed a positive trend between the pupil dilation response and the neural spread of association in parahippocampus-hippocampus (Fig. 6f ).

In addition, we identified a nominally significant enrichment for microglia/astrocyte OCRs in Alzheimer’s disease, which is consistent with a recent study implicating microglia enhancers in Alzheimer’s disease 38 The cell-specific map of chromatin accessibility generated in this study can be used to deconvolute bulk tissue ATAC-seq data from the human brain cortex.

Lower healthy tissue uptake (toxicity) with loading dose When the total antibody dose increased from 0.3 mg kg −1 to 2.6 mg kg −1 , muscle uptake of the antibody–dye conjugate (%ID kg −1 ) showed a decreasing trend (Fig. 2a ), suggesting that co-administration of unlabeled antibody saturates the estimated glomerular filtration rate (EGFR)-binding sites in the muscle and thus reduces the target-mediated uptake (relevant for ADC toxicity) in healthy tissue.

Measurements of major short-chain fatty acids (SCFAs) in the cecum and colon showed a trend of incremental increases of absolute and relative butyrate levels as AcGGM levels were increased (Fig. 2 ).

In fact, sporadic human cases caused by H7N9, H5N6, and H9N2 continue to be reported 5 , 57 , and the seroprevalence rate of H9N2 AIVs in the poultry workers posed an increasing trend after 2009 in China 7 , 58 .

After a 5-min SP test, however, we observed a significant (or almost significant) increase of c-Fos induction specifically in the MeA and NAc shell, but not in the LSD, LSV, or NAc core (Supplementary Fig. 8 ; one-way ANOVA, LSV— F 2,12 = 0.847, p = 0.453; LSD— F 2,12 = 2.327, p = 0.140; NAc core— F 2,12 = 0.444, p = 0.652; NAc shell— F 2,12 = 3.767, p = 0.057; MeA— F 2,12 = 7.161, p = 0.009).

A ISW1a-dinucleosome model was constructed based on these data, but has not been validated during the last nine years, even though it would be highly significant as thus far no other ATP-dependent chromatin remodeler is known to act specifically on dinucleosomes.

During the historical simulation period, the multi-model ensemble interquartile range (IQR—25th, 50th, and 75th percentiles) of the 20 climate models shows a decreasing trend from ~1940–1980 C.E.

Introduction For locally advanced gastric cancer (LAGC), there has been a positive trend in neoadjuvant chemotherapy after the milestone publication of the MAGIC trial in 2006, and results from this trial were recently even supported by those from clinical trials from Asian countries 1 – 5 .

For migraine and T2D in contrast there was evidence of residual pleiotropic effects (significant MR-Egger intercept, Supplementary Data 17 ) after removal of potentially pleiotropic outlier variants, and the association became only nominally significant for migraine.

P < 0.05, P < 0.01, and P < 0.001 were considered significant (* or a ), very significant (** or aa ) and extremely significant (*** or aaa ), respectively.

Although HMGB1 did not reach statistical significance, it still showed a clear trend that higher expression indicated a worse prognosis (Supplementary Figs. 9 and 10 ).

Cd4 − Cd8a + selection intermediates expressed slightly less Cd69, Egr1 and Itm2a , (but not Nr4a1 ) than Cd4 + Cd8a − selection intermediates, but differences in TCR signalling gene expression between subsets of selection intermediates were minor compared to the highly significant changes from pre-selection DP to selection intermediates (Fig. 3a ).

MHC class II −/− selection intermediates showed a notable trend for increased expression of the IL7R downstream gene Gimap3 as well as Runx1 and Runx3 as potential mediators of coreceptor switching from Cd4 + Cd8a − to Cd4 − Cd8a + (refs. 4 , 20 , 22 ).

Furthermore, we found a decrease in AP half-width and there was, though not significant, an increasing trend in the dF/dI, which are in line with decreasing AP half-width and increasing maximum firing frequency reported in developing dentate gyrus PV cells 38 .

However, SR3335 significantly inhibited the expression of IL-17A in the human memory T H 17 cultures but did not quite reach significance in the T H 17.1 cultures.

2f, g , respectively, displaying a clear trend of higher RhO x extent for increasing SDP and SEP.

Comparing these ITHs, we found a strong correlation between immune-ITH and RNA-ITH and a positive trend with DNA-ITH (Supplementary Fig. 6a ), indicating a closer relationship between immune and tumour transcriptome landscapes.

WNT2B-treated pellets also showed a trend toward the increasing expression of neurogenic markers ( PAX6 and SOX2 ), although not statistically significant.

Comparing the phase-locked conditions, we found that the reduction in tremor amplitude was close to significance (not corrected) only at a phase-lag of 0° (Fig. 4a ) but the number of participants who showed a significant reduction in tremor amplitude was not significant (Fig. 4b ).

The amplitude starts to increase after t = 7.64 s (with an unidentified small T e drop event), and it shows an increasing trend before the disruption at t = 7.673 s and remains significant for the stochastic period.

From 2008 to 2016, the import flows of Southeast Asia 5 basically showed a trend of year-on-year increase (from 2.6 × 10 5 to 8.1 × 10 5 tons), with a good linear fitting effect ( R =0.936) and an average annual growth rate of 15.2%.

In the situation where the data of the 9 years (from 2008 to 2016) fluctuate slightly and show an obvious trend, we used the average value of trade data from 2013 to 2016 to represent the Baseline Scenario; if it fluctuates greatly with no obvious future trend projection, the data of all 9 years is considered, and the average calculated to represent the Baseline Scenario.

By contrast, a clear trend is identified with respect to the relative energetic position of the CT state and the C 60 T 1 38 , 39 .

We observed highly significant reductions (67%, n = 2 biological replicates) in chromatin accessibility at the super-enhancers compared with less (23%) reduction at the typical enhancers (Fig. 3a , Supplementary Data 7 ).