Excerpts

This study uses one-way sensitivity analysis to emphasize how single vaccine characteristics may be significant in favouring one vaccine product over the other.

At the assemblage level, we observed a negative relationship between D 50 (median sediment particle size) and % tolerant individuals as well as a positive trend between incision ratio and % generalists over study years.

“Bed Characteristics + Year” was best supported for Δ % Generalists (ΔAICc = 0.00), displaying a negative trend with D 50 . Δ % Herbivores was best modeled by “Year-only” (ΔAICc = 0.00), although the “Hydrologic Variability + Year” model was also supported (ΔAICc = 0.80). Δ % Tolerant was best modeled by the “Bed Characteristics + Year + Riparian Canopy” model (ΔAICc = 0.00), with a significant negative relationship with riparian canopy cover and a negative trend with D 50 , while the “Riparian Canopy + Year” model was also supported and showed the same negative relationship with riparian canopy cover (ΔAICc = 1.28, Table 4 ).

Although androgen levels were not included in the model (due to a low number of valid samples), it is worth mentioning that circulating 11-KT levels showed a positive trend with DNN, although the dataset was too small for sufficiently powerful statistical analysis.

For DENV-4, cumulative endpoint rates decreased with increasing Month 13 serotype-matched titers in both treatment groups, with low cumulative DENV-4 rates at low titers (Panels G and H of Fig 6 ), and a borderline significant result that the rate was lower in the vaccine group at low titers.

BMP7-treated cell/scaffold constructs showed a trend toward increasing width and length compared to their non-treated counterparts ( Fig 2 and Table 2 ).

However, microtia cells treated with BMP7 showed a strong trend toward increased expression of type II collagen and elastin when compared to all other groups.

Microtia samples with BMP7 addition showed a trend toward greater expression of elastin, type II collagen and SOX5 compared to all other groups ( Table 3 , trendline slopes), and both BMP7-enhanced groups exhibited a decreasing trend in type III collagen gene expression when compared with their respective groups without the growth factor ( Table 3 , trendline slopes).

Rectangles highlight those clusters with a highly significant p-value (0.05).

RT-qPCR analysis showed an increasing trend in gene expression levels of elastin, type II collagen and SOX5 in the microtia group in the presence of BMP7 compared to the other three groups, and both microtia and normal neocartilage groups with BMP7 supplementation were found with decreased type III collagen expression compared to the respective two groups without BMP7 addition.

At present, there is an increasing trend to rely on patient self-reported questionnaires of disease activity and treatment response for monitoring patient status and adjusting treatment if necessary [ 35 ].

According to the simple linear regression for the long-term GSVI, there was a slightly increasing trend in the GSVI with a slope of 0.0002 for the entire study period.

In the spatial pattern, the multiyear averaged GSVI showed a decreasing trend from the southeastern to northwestern TP, which was consistent with the distribution of the climatic factors and terrestrial characteristics.

Then, the GSVI during the period from 1995–2000 reversed to showed an increasing trend.

This trait can be identified from the fact that most of the pixels showing a positive trend fell in the slope interval 0–0.14.

Temporal patterns of distribution Seasonal components (sine and cosine transformations of day-of-year) were retained as highly significant in the final GARMA models for both species ( Table 2 ).

Moreover, our results indicate a decreasing trend in PA for the transition from primary to secondary school.

The highly significant correlation found between AFB 1 -dialdehyde and AFB 1 -monoalcohol reductase activities strongly suggests that the same enzyme catalyzes both activities.

Hence, there was a clear trend of suburbanization of residential functions.

- The lack of statistical power of the pCR and RCB-I luminal BC subgroups was mentioned in the discussion, and new analyses were performed pooling together pCR and RCB-I luminal BC subgroups to address this issue (with an almost significant p-value of 0.069). - We also inserted a paragraph describing the meta-analysis of more than 5000 individuals RCB data with long-term follow up which was recently presented by Symmans and colleagues. - Analyses were reconducted only taking into account the subset of patients whose LVI status had bee

Although ER stress markers GRP78 and ATF4 showed an increasing trend in expression compared to control, the difference was not significant.

Hence, highly significant or top GO term/functionality was assigned to the respective hypothetical hub gene in a module.

When evaluated over time (by the end of project year 1, year 2 and year 3), the ICER showed a decreasing trend, reflecting decreased marginal costs but also increased marginal effectiveness during the project’s implementation timeline ( S1 and S2 Figs).

Enhanced oxidative stress in in vivo glycated erythrocytes may be significant and moderate enough to trigger proteasome LLVY activation.

Kinome sequencing reveals JAK3 as mutated gene in HGSOC JAK3 (N = 8/124, 6.4%) was the most frequently mutated kinase gene with a trend toward significance after correcting for gene size (multiple testing q-value = 0.1).