Excerpts

CRK rs7208768 had a marginally significant gene-dose effect. 100,000 permutation tests in the single SNP analysis showed SRC rs6122566, c-MET rs41739 and CRK rs7208768 with the most significant permutated p -value in each gene ( p permutation = 0.00284, p permutation = 0.00989, p permutation = 0.01392, respectively).

In the delta and theta bands, relatively few highly significant differences in connection strength were found after applying Bonferroni correction.

After 105 days in the protocol, the difference in body weight and fat mass between the control and LUN group where highly significant; however, differences in body weight changes from 98 to 105 days did not reach significance Fig. 3B and food intake per g of lean mass was not different ( Fig. 3C ).

In sharp contrast, 24 hours after LPS treatment, the numbers of tissue-infiltrating macrophages were substantially increased by 3–4 folds in a highly significant statistical manner with P -values of 0.04 and 0.006 for CD11b + and F4/80 + cells, respectively ( Figs. 2B and 2C ).

Results of the replication study Four SNPs which showed a statistically significant (rs1202168, rs1045642, rs868755) or borderline significant (rs9282564) association in the German discovery set were typed in an additional set of CRC cases and healthy controls from Germany.

A highly significant effect was seen with subjects treated with angiotensin II receptor antagonists; there were too few of these to analyse the data in the same way, but in the group of all subjects without diabetes being treated with these drugs (n = 24) the correlation between log(urine betaine excretion) and log(plasma homocysteine), Pearson's r = +0.77 (p = 0.00001); if subjects with diabetes are included (n = 34), r = +0.44 (p = 0.009).

In ACS subjects with above median betaine excretion a positive trend (r = +0.10) between betaine excretion and homocysteine was not significant; the corresponding correlation in lipid clinic subjects was r = +0.42 (p = 0.0001).

Uncorrected p-values<5 e-07 were taken as very strong proof of genome-wide association, while p-values between 5 e-07 and 5 e-05 were considered as moderately significant associations (Wellcome Trust Case Control Consortium 2007).

In addition, the growth reductions in all but the northernmost counties were found to be marginally significant, which is noteworthy considering that the available time series were relatively short (n = 56) compared to the recommendations for interrupted ARIMA analysis [26] .

Moreover, while Norway spruce growth anomalies (after controlling for the influence of climate) in the years 2005–2007 showed a positive trend for the rest of Sweden they decreased in the counties affected by Gudrun ( Figure 3a,b ).

The younger male Dig showed a trend to intervene preferentially in male-male conflicts compared to the other classes (see Fig. 2b ).

[15] found little evidence of taxonomic distinctiveness between the two subspecies, based on a phylogenetic reconstruction of mtDNA sequences, but did find highly significant differentiation between the three Southern Hemisphere populations based on mtDNA haplotype frequencies and a high probability of population assignment using seven microsatellite loci [15] .

However, for HIV-1 BAL there was a significant trend of enrichment in transmitted variants, regardless whether the identical sequences were removed or not for the analysis.

However, because the number of replicate sites that we studied was modest and because we were concerned about falsely rejecting the hypothesis that oil exposure affected our response variables, we considered p-values between 0.05 and 0.10 as marginally significant and indicative of strong trends.

jensenii colonized cultures did not show significant reductions following PIC application although there was an apparent trend.

Some ethnic backgrounds retained marginal significance, in particular Gypsies (aOR 8.26, CI 1.03–66.34) and Amerinds (aOR 2.30, CI 1.16–4.58).

Identification of such markers might be significant in profiling the circulating tumor cells and predicting the patterns of metastasis in patients.

Following stimulation of the lShell, responding for sucrose under a progressive ratio schedule decreased significantly, but there was a strong trend towards increased responding for sucrose under a fixed ratio 1 schedule of reinforcement, both in terms of obtained rewards as well as number of responses on the active lever.

Introduction The role of wild birds in the transmission of AIVs has become highly significant with the introduction and spread of Highly Pathogenic Avian Influenza Viruses (HPAIV) of the H5N1 subtype into different countries in Asia, Europe, and Africa [1] , [2] , [3] , [4] .

Of note, PSQ variables and particularly the resulting binary PSQ covariates were highly significant prognostic factors, whereas for MS-MLPA weaker associations were obtained.

In addition, the SNP-based linkage analysis identified a near-significant region of 0.19 Mb on Xp22.33, that spans the boundary between the pseudo-autosomal region and the X specific region (LOD = 2.94, figure 2 ).

Spatial processing demand significantly positively modulated the connection from SPL to FG, while lexical judgment demand significantly negatively modulated the connection of the SPL to FG and showed a trend to positively modulate in the connection from IFG to SPL.

The cellular sulfated GAG and C4S content are inversely and linearly related to the ARSB activity, including at baseline, and following hypoxia, silencing, and overexpression in the BEC and the NCM460 cells with highly significant inverse correlation (r = −0.99) ( Fig. 3C, 3D ).

p values<0.05 were considered statistically significant and p values<0.01 were considered highly significant.

Here, analyses on the complete dataset revealed highly significant correlations for all tests (distance matrices of CT min , T opt and CT max vs. geographic distance matrix), while Mantel tests on the European subset showed non-significant relationships at all (cf.