Excerpts

With interruption of Notch signalling, CD4 , IKZF1 , MAML1 and CDKN1B showed significantly increased expression in CB co-cultures, while HES1 was significantly decreased, and TCF7 and GATA3 showed an increasing trend.

It was also of interest to quantify the changes in %BF and PA required to make practically significant impacts on IR.

A negative trend for both sensitivity and linearity was observed with increased gelatin (factor A).

The capacity to load adjuvant-particles like AFCo2 or AFCo1 by simple admixing with antigen may be significant in epidemic settings where speed of vaccine manufacture is critical to minimize resultant mortality and/or morbidity [8] .

P-values ≤0.01 and ≤0.001 were considered highly significant (** and ***, respectively).

In addition to PPS, other risk factors such as age, cancer status and gender have been reported to be significant predictors of palliative patient survival in several studies [11] , [14] ._ENREF_18 In our study we did not adjust for other risk factors because though they may be significant predictors of survival for the cohort of patients in our dataset, they may not be in other palliative settings.

Neither the effect of interletter spacing ( F 1 (2, 42) = 2.13, MSE = 606.8, η 2 = .09, p = .13; F 2 (2, 224) <1, p >.41) nor the interaction between the two factors (both Fs <; both ps>.57) approached significance.

Ratings of the primed persons on scales of Perceived Humanness (PH) and feelings of Interpersonal Connectedness (IC) showed a highly significant effect of the priming manipulation, with higher ratings for H umanized than N eutral persons on both the PH scale (H umanized : M = 61.4, SE = 1.9, N eutral : M = 56.9, SE = 2.0, T(53) = 2.20, p = 0.016) and the IC scale (H umanized : M = 50.9, SE = 2.3, N eutral : M = 43.5, SE = 1.8, T(53) = 2.20,

The latter cluster did not survive the FWE-corrected threshold of 0.05, but showed a trend towards significance (p(corrected) = 0.069).

Although all ROIs show a clear trend for higher atrophy rates in Aβ + Ptau + group as compared with controls, differences were small and significant only for the amygdala and parahippocampal gyrus, with the isthmus cingulate approaching significance (numerical values, with 95% CIs and p-values for the comparison between groups for each ROI, are shown in File S1 , Tables S2B).

Interestingly, the hippocampus showed a trend for elevated atrophy rate earlier in the disease process, when evidence of Aβ pathology was present, but in the absence of ptau pathology.

Finally, a slight trend has been observed here towards successively increasing risk of overweight in low birth weight subjects with increasing age, i.e. , in adulthood ( Table 1 ).

Water Quality, Diarrhea, and WAZ There was a suggestion of a positive trend between diarrhea prevalence and household fecal water contamination ( Figure 4 ).

Compared with nonsmokers, a borderline significant increased risk of metabolic syndrome was found in former male smokers ( Figure 3 , pooled RR 1.19, 95% CI: 1.00–1.42).

For both women and men, there was an increasing trend of BMI with wealth, but not with educational attainment.

Of the risk factors measured, marginally significant inverse associations were found between telomere length and waist-hip ratio, serum total cholesterol, and LDL cholesterol, which indicated that longer telomeres corresponded with a better health status ( File S2 ). hTERT Gene Variants Predispose to Telomere Length Shortening and PAD Risk The frequencies of rs2735940 and rs2853669 in the hTERT gene did not deviate significantly from Hardy-Weinberg equilibrium in this case-control sample population (all P >0.05).

As more patients could be recruited, the expression level of IL-17 between early- and advanced-disease might be significant.

0.5; p = 0.06), which almost reached statistical significance.

Identification of 3 genes with borderline significance by grouping samples according to individual gene expression level To further increase the possibility of identifying candidate genes, we performed an analysis based on individual gene expression level.

Propulsion during swimming is relatively slow and commonly described as smooth, while swimming-by-jumping results in much higher instantaneous velocities and unsteady motion, even in copepods where the influence of inertia may be significant [21] – [24] .

The effect of competition in the sun was not quite significant for A max (t-value of relationship = 1.55; a significant relationship is described by a t-value ≥1.96), but the best-fitting model included this pathway.

For instance, Posener and colleagues found no differences in hippocampal volume between depressed patients and controls, but highly significant group differences in hippocampal subregional shape using surface morphology analysis [24] .

An increasing trend of cumulative HCC incidences over the follow-up period was observed for all four enzymes.

In the univariate analysis, a highly significant dose response was observed ( P trend<0.001 for all analyses, Table S4 ).

Males and ever smokers had a borderline significant increase in HCC risk ( P value, 0.091 and 0.066, respectively).