Excerpts

Since many chemotherapeutic drugs are known to induce their cytotoxicity by increasing ROS levels, the results of this study are also highly significant in understanding the mechanism for adaptation to ROS-induced toxicity leading to acquired chemotherapeutic resistance in breast cancer cells.

Given that the mediation was approaching significance, this may suggest that with age come improvements in working memory capacity, which in turn lead to improvements in rule-based categorization performance.

It was found that although maximum temperature and minimum temperature both increased, the minimum temperature increased at a significantly faster pace in Group B than in Group A, resulting in a negative trend for the diurnal temperature range (DTR).

The estimate of the slope of the trend is calculated as: (6) A positive value of B means an increasing trend whereas a negative value means a decreasing trend.

Our comparison of MSMW and MSWE may constitute a highly conservative (though still robust and highly significant) effect size: the majority of studies that included MSWE in our review and meta-analysis did so using very high-risk samples, such as street-based illicit substance users and their sexual partners or STI clinic attendees [37] , [41] , [54] , [58] , [60] .

Moreover, the MAGIC trial [23] reported that the perioperative-chemotherapy group was accompanied with significantly smaller tumor maximum diameter, a greater proportion of stage T1 and T2 tumors, and a significant trend to less advanced nodal disease (N0/1) compared to the surgery group.

HapScore test with MNWS score resulted in a marginally significant model ( p global = 0.054).

Because the period effect was highly significant for most of the intakes and because interactions between the URNS and the period effects were also significant, results for period 1 and 2 were analysed and presented separately.

All values were highly significant and indicated a low genetic differentiation among populations.

Both diet (logrank, Mantel-Cox X 2 df = 3 = 105.4, p<0.0001) and initial density (logrank, Mantel-Cox X 2 df = 3 = 93.99, p<0.0001) demonstrated highly significant differences in survival functions, and these differences were evident at every level of each factor ( Fig. 6C ; Fig. 6D ).

Trends were considered only weakly significant if both coefficients were negative but non-significant for one of the tests.

This may result in a situation that the Pearson correlation coefficients may be significant, but not especially strong.

We found a significant trend for increasing seropositivity with increasing age (p for trend <0.001).

But is demarcation activity around evolution more or less significant to public discourse than demarcation activity around around some other topic?

T2 values measured in this study was higher at caudal levels in both the NP (C4–5 to C6–7) and the AF (C2–3 to C6–7), with an increasing trend of T2 values proceeding cranially up the spinal column.

Patients with prior knee injection observed a significant improvement in mean pain with LMWF-5A as compared to vehicle control at week 12, while patients without prior knee injection saw a borderline significant improvement in pain with LMWF-5A as compared to vehicle control at week 12 ( table 3 ).

PERαKO −/− female mice showed a trend toward decreased pancreatic insulin concentration, an observation that was consistent with the known effect of ERα in stimulating insulin synthesis [6] , [7] .

When participants were categorized into 3 groups according to tertile values of RTL in controls, we observed a borderline significant relationship between shorter RTL and increased CRC risk (OR per tertile = 1.13, 95%CI: 1.00–1.28, P trend = 0.045).

Fine root biomass showed a decreasing trend with fertilization although no significant differences were observed ( Fig.

Children from the intervention showed a trend towards higher levels of physical activity.

Thus, we have not considered one isolated highly significant intervention effect as proof of success of our intervention, but originally expected a promising public health intervention to have beneficial and relevant effects in most, if not all dimensions.

Locations of possibly significant NifA, σ N recognition sites upstream of genes and potential transcription terminators downstream of genes were also presented in Table.3 .

Furthermore, the Cambridge Index showed a trend for all PA variables in men but not in women; this might be due to higher activity levels in men and/or male patterns of PA being easier to recall or score with this index.

The results were quite similar to those first presented in the literature despite a small trend toward an improved disease control rate (48.9%), PFS (8 months) and OS (11 months).

When analyzed separately, AIS girls were found to have numerically lower bone mineral status in all bone compartments with marginally significant difference detected for average vBMD and cortical vBMD.