Barely Significant

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The subgroup analyses of the overall survival and global DNA hypomethylation status detected a little significant correlation in the patients with a global DNA methylation rate less than 50% (HR, 2.52; 95%CI, 1.72–3.71; I 2 , 54.2%).However, after stratification by mean age, year of publication, mean follow-up, biological samples used, hypomethylation cut-off, and test method, no significant results were found.
Higher-frequency oscillations (such as those associated with solar activity) [10] are contained in the residuals; e.g., EVs #7 and #8 define a 13-year period signal, while EVs #9 and #10 define an 18-year period signal (also identified through the slightly significant autocorrelation values at time lags 13 and 18 years in Fig. 2c ).