Barely Significant

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(Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: This is a high-quality methodological study that provides important quantitative evidence and practical design recommendations for an under-researched yet practically significant issue in small-sample clinical trials, such as those for rare diseases: the impact of allocation bias on stratified analysis with multi-component endpoints.
Data analysis showed that in medium-high altitude areas, especially high-altitude regions, the detection rate of deafness mutant genes showed a decreasing trend, and some gene loci were even not detected, suggesting that the high-altitude environment may have a selective effect on deafness gene mutations.
On the contrary, the detection rate of deafness susceptibility genes in Mongolian and Hui neonates in high-altitude areas shows an increasing trend. http://dx.doi.org/10.13039/501100011501 Qinghai Provincial Department of Science and Technology 2023-SF-129 https://orcid.org/0009-0001-5320-1063 Wang Yi This study was supported by the Foundation of Qinghai Provincial Department of Science and Technology of China (Project No. 2023-SF-129).
2) There appears to be no significant difference in vascular function between Post-COVID and Non–Post-COVID groups: No statistically significant difference in FMD was found between groups (although a slight trend was observed); No difference in central systolic or diastolic blood pressure was observed (although the statistical power is limited). 3) There is an association between autoantibodies and vascular parameters within the Post-COVID group.