Excerpts

A clear trend of enrichment of basic residues is found in key sites which have been shown to form an interacting surface with the ion channel, including K3, K6, K26 and K28 in DTX-K [25] .

First, the increase in the AUC (from 0.787 to 0.798 for CHD, from 0.822 to 0.829 for stroke) reached a borderline significant level after adding IMT to the models with traditional risk factors for CHD.

(B) For pyrilamine, after the odor was presented, the 10 mM and the 1 mM groups maintained the PER for a longer time than the control group, and showed a trend for reduced olfactory interference.

The 5–9 and 10–14 year old group GIA did not differ significantly from each other, though a decreasing trend was apparent.

This proportion was highly significant compared to other families of transcription factors ( Table 1 ), and associated with an excess of induced transcripts.

The impact of utilization of local reference ranges may be significant in reducing screening to enrollment ratios in clinical trials.

A clear trend could be observed with respect to number of hydrogen bonds and the number of residues in the secondary structure.

However some genes with high signal may be significant despite showing relative low variance, and for these reasons it is better to apply combined filters that explore the variance, but also consider the intensity of the probes [15] .

The downstream effects of the elevated levels of important regulatory proteins on cellular signal pathways are likely to be significant.

Second, highly significant positive correlations between RT and activation were found predominantly in frontal regions, though several regions in parietal cortex and the thalamus also showed a positive correlation (p<.05).

The larvae infected with a mixture of dead color mutant conidia and live wild-type conidia showed a trend with increased mortality rates compared to those infected with a mixture of dead and live spores of only wild-type strains ( Figure 10C ).

These Neu5Gc-incorporation phenomena are practically significant, because normal humans can have high levels of circulating anti-Neu5Gc antibodies.

A positive trend of sensitivity with increasing CD4 cell count was observed for HIV-positive patients when stratifying CD4 cell counts into groups of <100, 100–200, 200–300, 300–400, 400–500, >500 (p = 0.03).

Similar to the findings of Raby et al [16] , we have demonstrated a clear trend of decreasing sensitivity with decreasing CD4 cell count in HIV-positive patients.

The near-significant correlation between increases in roe deer density and incidence of TBE in the alpine provinces of north-eastern Italy partially supports our hypothesis that large vertebrate hosts could play a crucial role in TBE upsurge.

In white light, two QTL were significant, with a major-effect QTL detected on the top of chromosome 5 ( Figure 5C ), while in far-red light, a single marginally significant QTL was detected on the bottom of chromosome 4 ( Figure 5D ).

Linear regression analyses showed highly significant associations between perceived step height and maximum toe elevation for all conditions.

No effect or interaction approached significance (all p s>0.2).

First, the sample size was relatively small which might explain the marginal significance level of the effect of unpaid assistance and emotional support on MD.

deaths show a decreasing trend after remaining almost constant (though high) over the period June–October, 2006.

In the second order models, we choose the variables exhibiting highly significant partial t -statistic and we continue this process with higher order models (considering higher order non-linearity) until all variables are exhausted or no other variables meet the criterion set above, whichever earlier.

Therefore, although statistically highly significant, adiponectin levels are associated with a very modest decrease in total coronary plaque burden accounting for only 3% of the variability in total number of coronary plaques.

This situation changed acutely when, in 2007, several animals with severe clinical signs were found to be infected with FeLV and eventually died, the statistical association between FeLV infection and death being highly significant.

Figure 3 shows that there is a modest but highly significant correlation between copy number and hBD-2 protein concentration in serum.

The increased HIV seroprevalence in older women and men may represent a cohort effect (i.e., the higher prevalence in younger women in the 1997 survey are now reflected in the cohort almost 10 years older), or could alternatively demonstrate a worrying trend towards increased HIV seroconversion in this age group.