Excerpts

Based on years of data, the annual average temperature of the Guanting Reservoir showed a trend of increase, whereas the rainfall displayed a downward trend.

Correlation analysis showed that the impact of soil factors on diversity was not significant at a subarea scale, although these nutrients showed an increasing trend with the community succession.

Most important was that there was a highly significant correlation between the amplitude of the sine wave, and the ovality ratio, a commonly used method to quantify the degree of the optic disc tilt.

An increasing trend of DNA methylation level during plant growth and development has been reported in Arabidopsis , tomato, and rice [ 8 , 13 , 14 ], however aberrant methylation could impede normal development and reduce fertility as demonstrated in MET1 loss of function of Arabidopsis [ 15 ].

After inclusion of all five PFAS in the model, PFNA continued to show a highly significant association with miscarriage.

Discussion In this case-control study we found strongly significant associations between serum concentrations of PFAS (PFDA and especially, PFNA) and miscarriage and almost significant association with PFHxS exposure.

In an unadjusted logistic regression, a significant trend was found for miscarriage OR in regard to PFNA and PFDA tertiles.

Implications for Clinical Practice and Research Our study demonstrates that MCS has a strong trend toward late local and metastatic recurrence.

2092 vs 2043), comparing the observed numbers in areas within a high density cluster compared to areas outside the clusters may be significant biologically and would be beneficial in guiding the geographical focus of future studies investigating reasons for observed spatial patterns.

Results reveal that BST-2 mRNA expression is inversely correlated to its DNA methylation status ( Fig 2A ) with a highly significant r 2 value of -0.720.

The whole-brain analysis revealed two highly significant clusters where patients had increased activity compared to healthy controls, which include the midbrain and superior frontal regions.

There was also an increasing trend of PCa detection in men with a BMI ≥18.5 kg/m 2 , while the trend was inverted when the BMI was lower than 18.5 kg/m 2 .

Moreover, the reticulocyte count showed a trend towards reduced values, suggesting a reduced erythropoietic response to overcome the anemia.

The reason to expect so many marginally significant results would derive from the nature of the immune response, where host resistance is dependent on many individual immunological responses [ 40 – 44 ], as well as peristalsis [ 45 – 47 ], which plays important role on parasite expulsion.

REM sleep latency decreased with increasing HbA1c with a significant trend (p value for trend is 0.004).

Similarly, protein levels of myogenin also showed a trend of higher levels starting from day 3 of differentiation (Fig 1C and 1D ).

However, those genes that are identified as being marginally significant by only one method should be carefully double-checked before being classified.

The second marginally significant window involves a similar scenario where RG35 is nested within the clade of French lines, sister to the French line FR229 ( S9 Fig ).

The person-specific effects were found to be highly significant.

X OM exhibited a highly significant and negative correlation with 4’-demethylpodophyllotoxin (R = –0.968), whereas the X JMT demonstrated significant and positive correlation (R = 0.953).

The differences in prevalence between kidney and liver (p-value: 0.07) and kidney and lung (p-value: 0.07) were marginally significant.

Although no significant effect for bystanders’ attitude toward the participants on participants’ perceived performance ( H1a ) was found for the whole dataset, the effect approached significance in the hypothesized direction.

Accordingly, these three genes showed highly significant correlation of their expression pattern, based on transcriptome analysis [ 20 ].

Carbon emissions of urban households in the YRD can be expected to maintain an increasing trend with the ongoing process of urbanization and economic development in the next decade.

It can be observed that the highly significant markers were not always the SNPs with the greatest effect.