Excerpts

Furthermore, we could see a significant trend where the G residues in the first position of the G YW motifs ( Table 2 ) or the second position of R G YW motifs ( Table S3 ) were more mutated in the NBS patients, whereas no difference in targeting of the corresponding C residues in the reverse complementary motifs (WR C or WR C Y) was observed ( Table 2 and S3 ).

We observed a weak trend indicating that domain residues contacting mostly residues in the linear motif were more conserved than those contacting the context.

Parametric modulation of the functional imaging data revealed a highly significant linear increase of cortical activity in the medial frontal cortex as well as in the right temporo-parietal junction in correspondence with the increase of human-likeness of the interaction partner (computer<functional robot<anthropomorphic robot<human).

Third, the size of the patient sample may have been too small to yield significant correlations, although other studies with similar sample sizes have reported highly significant correlations between proprioceptive thresholds and disease severity in PD [11] .

A probability level of p<0.05 was considered significant, p<0.10 was considered a significant trend.

Secondly, whenever this first stage showed a significant correlation or a strong trend for an activated region (e.g. striatum and amygdala), we performed a whole-brain multiple regression analysis on the contrast image of interest using the relevant questionnaire scores (e.g.

However, a recent meta-analysis of clinical trial outcomes for the PPARγ agonist rosiglitazone found a significant increase in the risk of myocardial infarction, and a borderline significant risk of death from cardiovascular causes [4] .

These sources of uncertainty may be significant when, as in the case of rainfall, the climate variables are particularly important determinants of plant distributions [59] .

In addition, the genes in this cluster also showed a trend of down-regulation in hyphae which suggested that, unlike the 244 up-regulated genes, decreases in the mRNA levels of this cluster of genes was not specific for conidia.

One initial hypothesis was that there would be an obvious trend in the gene expression data reflecting the progressive nature of SSc in some patients.

Vitreous chamber depths showed a main effect for drug conditions with less depth change in response to defocus shown for Ba 2+ relative to Saline, while bumetanide injected eyes showed a trend to increased depth without a significant interaction with applied defocus.

For example, the differences between the 8-month AL liver weights (377±15 g) and calorie-restricted animals (268±5 g) is highly significant.

Tactile activity in this occipital ROI showed a clear trend across days towards increasing differential activation between the blindfold and non-blindfold control groups, with the greatest difference found at the end of the blindfolding period on day 5 ( figure 4B ).

all the genes that are reported in a particular list, the P-value associated with the number of genes contained in this list will likely be highly significant according to how unlikely it is to obtain all the genes contained in a given list in a random draw from all genes present in the bipartite graph.

The largest difference was a 38% increase in perceived albedo and differences are both highly significant and patterned.

A similar excess of intermediate frequency variants was observed in non-African populations, which tend to have positive Tajima's D values at the genome-wide level; yet, the Tajima's D value at NAT2 is unusual in the European and Asian samples (though only marginally significant in the latter) when compared to neutral expectations for two different bottleneck models.

Early training (first 3 or 4 trials) on the finger tapping task led to a rapid and highly significant gain in speed (∼16% per trial); further practice led to a smaller, but still significant, gain (∼1% per trial).

However, it may be significant that in Tragopogon polyploids, all the imbalances in parental chromosome dosages between individuals occurred within a near-regular karyotype of 2 n = 24 (one exception at 2 n = 23).

Transfected cells were incubated, at low density, in the presence of hygromycin (600 μg/ml) and 2 individual clones with highly significant reduction of DNA-PKcs expression were obtained (further named DNA-PKcs KD in our study, KD standing for kinase dead).

Figure 3 shows additional changes in expression scores that were considered significant or highly significant.

Linkage disequilibrium measures are highly significant between SNPs rs1327328 and rs7326018 and SNP rs4284505, located next to a cluster of microRNAs, and marginally significant with SNP rs9583760, located within LOC121727 (similar to Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3)).

As illustrated in Figure 8 , the sliding window analysis shows a large, highly significant eye position effect developing after the eye movement to target.

Contrastingly, baseline levels of oCRY1 showed a trend towards higher levels by co-transfection of oFbxl3sv, in-line with the predicted impaired coupling to the proteasome degradation pathway and suggestive of a dominant-negative effect.

This proportion was highly significant compared to other families of transcription factors ( Table 1 ), and associated with an excess of induced transcripts.

The impact of utilization of local reference ranges may be significant in reducing screening to enrollment ratios in clinical trials.