Barely Significant

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The GEICAM-9401 and SWOG-8814 studies showed a trend to inferior survival outcomes with concurrent tamoxifen and chemotherapy, but the results were not statistically significant in either study. 16 , 17 An Italian randomized trial evaluated concurrent or sequential tamoxifen administration with anthracycline-based adjuvant chemotherapy and suggested
We observed a strong trend towards decreased levels of NEDD8-conjugated proteins upon treatment with MLN4924, though only reaching statistical significance in TDP-43 G348C MNs (Isog Ctrl P = 0.0799; TDP-43 A382T P = 0.0705; TDP-43 G348C P = 0.0266 by one-way ANOVA with Sidak’s multiple comparisons test) (Fig. 6 c, f, Supplementary Fig.