Barely Significant

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approached significancep = 0.0591.2× alpha
Univariate GLM analysis showed that the difference between depression ratings under MDMA and placebo of both female genotype groups was statistically significant ( F 1,39 = 4.76, p = 0.04, ƞ p 2 = 0.19); for males this difference approached significance ( F 1,39 = 3.78, p = 0.059, ƞ p 2 = 0.09).
a strong trendp = 0.0591.2× alphagold
Post-hoc tests on AUC error (Bonferroni corrected for multiple comparisons) following a significant Task*Stimulation Group interaction; F(2, 86) = 15.33, p < 0.001, ηp 2 = 0.26, revealed this trend was significant between the cerebellar and M1 group ( p = 0.019) while a strong trend was found for the cerebellar and sham group difference ( p = 0.059).
near-significantp = 0.0591.2× alphagold
Following this up with two separate analysis for each assessment day, we found the main effect of stimulation on the second (but not the first) day of assessment at the level of near-significant tendency (F (2; 69) = 2.944; p = 0.059; ηp 2 = 0.079), with higher accuracy for abstract words in anodal tDCS than in sham group, albeit only at tendency level (p = 0.091; Z = − 2.2) (Fig. 5 ).
a positive trendp = .0591.2× alphagold
Significant individual predictors: Involuntary memory While Model 3 (see Table 4 ) was statistically significant, none of the individual predictors reached conventional levels of significance, although MAIA Noticing showed a positive trend (B = 0.266, SE = 0.138, t = 1.92, p = .059, β = 0.245), suggesting individuals more attuned to bodily sensations may experience more involuntary memories.
marginally non-significantp =.0591.2× alpha
We found a small, marginally non-significant positive period × time interaction ( β = 0.002, 95% CI [−0.000, 0.004], t (49) = 1.946, p =.059), a non-significant effect of time ( β = −0.001, 95% CI [−0.003, 0.000], t (49) = −1.605, p =.117), and a significant negative effect of period ( β = −0.073, 95% CI [−0.135, −0.012], t (49) = −2.402, p =.021) (Supplementary Table S6, Figure S4).
close to significancep = 0.0591.2× alpha
As the same term was close to significance for state 1 with opposite sign ( t 6 = − 2.32, p = 0.059, Cohen’s d = − 0.55 ± 0.87), we probed the difference between state 1 and 3 counts (Counts 3 − Counts 1 ) in a follow-up analysis: the interaction remained significant ( t 6 = 4.6, p = 0.004, Cohen’s d = 1.08 ± 0.92), indicating that the more state 3 is expressed over state 1, the better the recovery, in a way that also depends on the MR signature.
showed a trendp = 0.0591.2× alpha
11 C-deuterium-L-deprenyl PET region of interest analysis Comparisons of four groups (presymptomatic ADAD carriers, MCI PIB+, sAD and ADAD non-carriers) using Kruskal-Wallis tests in each of 11 ROIs (except for the cerebellum), showed a trend toward statistical significance for the anterior cingulate cortex, the thalamus and the hippocampus (p = 0.059–0.069) ( Supplementary Table S1b ).
an increasing trendP = 0.0591.2× alphagold
Platelet aggregation Compared with the IR group, the clopidogrel + IR group had lower MaxAR-ADP (9.65 ± 5.60% vs 75.52 ± 14.99%, P < 0.05) and AveAR-ADP values (13.22 ± 5.81% vs 71.32 ± 16.66%, P < 0.05) and showed an increasing trend for MaxAT-ADP (447.67 ± 49.45 s vs 374.83 ± 67.81 s, P = 0.059); the TMAO + clopidogrel + IR group had lower MaxAR-ADP (35.05 + 24.93%, P < 0.05) and AveAR-ADP values (25.50 + 18.60%, P < 0.05).