Barely Significant

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The FEV 1 /FVC ratio followed the same pattern, showing a significant reduction in severe cases compared to mild and moderate asthma ( p < 0.0001), with no significant genotypic variation.FEV 1 reversibility, a key marker of bronchodilator response, also exhibited a decreasing trend with increasing severity, which aligns with the expected pathophysiology of β 2 agonist refractory asthma.