Barely Significant

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TLR variability and susceptibility to infection Linear modelling revealed several associations between risk of infection and presence of the most frequent amino-acid alleles (Table S6 ), yet after controlling for multiple comparisons, only the effects of the TLR1*aa10 and TLR5*aa02 on infection with the blood pathogen Bartonella remained significant or marginally significant (Table 4 ).
Both studies’ top SNPs in the basonuclin 2 gene ( BNC2 ) locus were only nominally significant in our data ( P rs2153271 = 0.0044; P rs62543565 = 0.0351), and in the interferon regulatory factor 4 ( IRF4 ), melanocortin 1 receptor ( MC1R ), and agouti signaling protein (ASIP ) loci, their top SNPs were predominantly monomorphic in 1000G East Asian samples (Supplementary Table S2 ) or were only weakly significant in our data (Table 2 ; P IRF4,rs9405675 = 0.0113; P MC1R:rs8060934 = 0.0027).
If social bonding, individual recognition, maintaining group cohesion and cooperation exert the major selection pressure 13 , 54 , then the eusocial species with extremely high reproductive skew towards a single breeding pair might be expected to show the largest brains and cognitive potential, since they live in the largest and most cohesive groups, with a decreasing trend towards the solitary end of the social spectrum.