Barely Significant

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With regard to the ANOVAs comparing secondary outcomes such as change in TQ, THI, TBF12, MDI, and WHOQoL-questionnaires, the main effect of time turned out significant for the change in the TQ score (baseline score: 33.08 ± 18.26; score at week 12: 29.89 ± 19.11) and marginally significant for the THI with effect sizes being moderate to high (for details see left part of Table 3 ).
In contrast, near-significant increases in risk for gallbladder cancer were observed for gallstone presence with the FEN1 -69G > A GA (OR = 2.3, 95% CI = 1.5–3.5) and the FEN14150G > T GT (OR = 3.7, 95% CI = 1.4–9.8), whereas significant increases in association for gallbladder cancer were observed for gallstone presence with the FEN1 -69G > A GG (OR = 6.8, 95% CI = 2.1–28.31) and the FEN14150G > T GG(OR = 7.2, 95% CI = 2.2–20.2).