In general, the main observation in the whole cohort was a strong trend of increasing nuclear MTA1 expression associated with worse pathologic parameters: localized PCa and metastatic lesions had significantly higher nuclear MTA1 levels compared with PIN.
While heating due to strong absorption of THz radiation by water in biological materials may be significant in the case of continuous-wave excitation 16 , average thermal effects are minimal for picosecond-duration THz pulse sources with low repetition rates 20 .
When the relationships between the longevity contrast and the contrast of specific FFA were assessed, statistically significant negative correlations were observed for all the analysed FFA, with the exception of docosahexaenoic acid, which exhibited a marginally significant correlation with MLSP (see Supplementary Table S3 ).
A further selection of the OTUs with the lowest p-values showed 6 taxa with a clear decreasing trend from NAG to IM to GC (2 TM7, 2 Porphyromonas sp , Neisseria sp and Streptococcus sinensis ), and 2 with an increasing trend ( Lactobacillus coleohominis and Lachnospiraceae).
Concerning changes in the microbiota, we found evidence of a gradual change in patients from NAG to IM to GC, bacterial diversity showed a trend to diminish from NAG to IM to GC, and was significantly higher in NAG than in GC patients.
Their shapes depend on the function considered and show an increasing trend with the log function, and an increasing and then decreasing trend with the quadratic function.
Statistical inferences drawn from our RT-qPCR gene expression analysis indicated that genes in RNA transport pathways, especially in NPC and SMN complexes, were highly significant and involved in maize resistance.
For the toluene SOA, the RI values change slightly under the low and high NO x levels, with the high NO x condition being slightly higher, but the SOA under the HONO condition gives a significantly higher RI value with a decreasing trend.
Furthermore, similar to the pattern during the last 1400 years, the Ti flux also showed a trend opposite from the SH 52 and AO 50 in the last 110 years.
Cells that were initially cultured on soft or stiff gels and transferred to gels of the opposite stiffness showed a trend in lineage marker expression that was dependent on cell shape.
Furthermore, in Pt/Co/Pt samples the DMI is an order of magnitude smaller, hence a tilting of at most 1 or 2 degrees might be induced, which is hardly significant and therefore not taken into account in the analysis.
But additional statistical analyses conducted on deep-sea nematodes and coral reef fishes revealed that the concave-up BEF relationships found in the above studies were still highly significant even after controlling for the effects of potential confounding environmental factors such as depth, food supply and other variables, either independently or simultaneously 12 13 .
There exists a large spatiotemporal variability in the daily rainfall; whereas the δ 18 O values of rain are significantly coherent at all the stations (linear cross-correlation coefficients of rain in different stations are mostly insignificant, while those of δ 18 O of rain between stations are highly significant, as shown in supplementary Table 1 ).