Excerpts

After light administration, PER3 4 /PER3 4 subjects advanced their aMT6s acrophase (p < 0.05), and showed a trend of advanced sleep-wake timing.

A highly significant statistical difference was observed for carp, medaka and rainbow trout when exposed to HCl as a positive control.

However, there is a clear trend of the fitted parameter θ to increase with complexity as measured by the number of TFs in the species (or alternatively by the total number of genes).

Furthermore, a main effect of group, F (1, 50) = 3.14, p = 0.08, η p 2 = 0.06, and a three-way interaction between music culture, timbre, and group, F (1, 50) = 3.57, p = 0.07, η p 2 = 0.03, reached a marginally significant level.

(2007) found that there is a negative trend in diagnostic accuracy with more recent studies 38 , which may be due to differences in the prevalence of ACL tears in the selected studies.

Interestingly, more gluten aggregates were formed in GMP gels of the mutant transgenic lines due to their highly significant increases in the amounts of large- and medium-sized polymers (Fig. 4B and D ).

Glycogen synthase (GS) expression showed a somewhat decreasing trend before showing an increasing trend; the lowest level of GS was observed in the group fed with a dietary arginine level of 1.62% (Fig. 2E ).

The relative expression of Akt in the groups fed with dietary arginine levels of 1.62, 1.96 and 2.31% were significantly upregulated and thereafter showed a decreasing trend (Fig. 1C ).

In contrast to previous studies that have indicated a highly significant correlation between expression of lncRNAs and the neighboring mRNAs, this did not appear to be the case in the muscle biopsies 25 , 26 .

In contrast to the results for TG, LDL-C, and TG/HDL-C ratio quartiles, there was a negative trend for the association across increasing HDL-C quartiles and incidence of POF, PNec and in-hospital death, p values for trends across quartiles were <0.001, <0.001 and 0.043, respectively.

Moreover, there was a positive trend for the association across increasing HDL-C quartiles and POF, PNec and mortality after multivariable analysis (p values were <0.001, <0.001 and 0.043, respectively).

Only Hequ and Xingxian stations exhibited decreasing trends in February, and only Suide exhibited a decreasing trend in June.

Winter precipitation at most stations in the study area displayed an increasing trend and most stations exhibited decreasing trends in the spring, summer autumn.

Finally, in subgroup analysis, pATR expression and the pATR/pChk2 co-expression model were associated with an increased risk of death within a 10-year timeframe in the subgroup of patients with elevated Ki-67 levels and with node-positive disease (Supplementary Figure 1 ), although to a borderline significant extent.

In conclusion, mouse strain differences in the sensitivity to SSRI treatments were correlated with 5-HT transporter binding and reuptake in these mice, suggesting that the binding and uptake efficiency of the membrane-bound 5-HT transporter may be significant contributing factors to the marked strain differences in immobility time in the TST and FST.

In the GRK2 siRNA-transfected ob/ob mice, the hypoglycemic effects of insulin administration showed a trend similar to that in the control siRNA-transfected lean mice (Supplementary Fig. 4C ).

LINC - ROR rs2027701 showed an obvious trend towards a superior reaction with toxic effects in patients with one or two variant alleles compared with those with the wild-type genotype (OR = 0.503, 95%CI = 0.303–0.835, P = 0.008).

A clear trend, for example, is seen in the drug design industry: Sanofi signed a $120 M deal with Schrödinger, a molecular modeling software company, in 2015.

Although our results showed a trend of increasing antioxidant capacity, the significantly decreased oxidative stress may suggest the possibility of the reduced occurrence of oxidative damage, which may partially contribute to improving functional and health-related outcomes.

From Table 1 , it is obvious that C 4 shows an increasing trend (+0.003% yr −1 ), whereas those of C 5 –C 12 diacids (particularly, C 5 , C 7 , C 8 , C 9 , and C 12 ) show significant (p < 0.05) decreasing trends during the study period.

The APRI, FIB-4, RPR and GPR showed an increasing trend with fibrosis stages in CHB patients.

Moreover, when promoter occupancy of Pol I and UBF was compared between PGC-1α competent wild-type and PGC-1α knock-out tissue, we found a highly significant difference of Pol I and UBF binding to the rDNA promoter after precipitating the same amount of protein (Fig. 3b ).

In fact, at the highest dose of 10 μM, RGFP966 exposure resulted in a slight trend of decrease in neurite length (Fig. 5a ).

The values of the maximum quantum yield of photosystem II ( F v / F m ), the effective photochemical quantum yield of PSII (ΦPSII), and the photochemical quenching ( qP ) showed a decreasing trend related to NaCl concentration and treatment duration (Fig. 1A–C ).

Consistently, no additional significant increase in LC3-II was observed in the CQ plus ZAS-treated group compared to the ZAS only-treated group, as determined by the western blot assay, although an increasing trend was observed at 4 h (Fig. 4C,D ).