Excerpts

An interesting trend was elucidated by Hay et al. in 2014 16 , where the success rate of drugs entered clinical development in phase I and subsequently approved by the US Food and Drug Administration (FDA) is nearly one-in-six.

The post-hoc Dunn’s test showed highly significant differences between LG05, LG13, LG03 and LG11 from the other chromosomes (Supplemental Table 1 ).

Both complete datasets and the WCM open-habitat subset showed a highly significant correlation, while both BMH subsets showed a less significant correlation (but see lower sample size in the latter).

WCM forest subset showed only a marginally significant correlation, despite a higher sample size (Supplementary Table S3 and Fig.

LowSupp had the greatest Ct.BMD of the three groups and showed a trend for decreased resorption and formation in the cortical region, while OPSupp had the lowest Ct.BMD and showed a trend for increased formation in both the trabecular and cortical regions.

Mortality showed a decreasing trend in the experimental group, but the results were not statistically significant.

One can see that the difference in localization power between ET or CE alone compared to their combination is quite significant both at low and high redshift.

Patients with excess blasts (RAEB1/2) tended to have lower AMC (median 0.19 versus 0.32 for patients without excess blasts, p < 0.0001) and lower AMC were found in higher IPSS-R categories (very low, 0.37 × 109/L; low, 0.30 × 109/L; intermediate, 0.25 × 109/L; high, 0.16 × 109/L; very high, 0.20 × 109/L), while there was a highly significant difference in the AMC between higher risk (intermediate, high, very high) and lower risk (very low and low) MDS according to the IPSS-R (0.21 × 10 9 /L vs 0.33 × 10 9 /L, p < 0.0001).

4 ), indicating the differential expression was highly significant at FDR < 0.05.

The results of the present study indicated that PCSK9 was associated with AMI and cardiovascular death, although these associations were only borderline significant and could not be confirmed by Cox regression or extended comparison, which may be due to limitations imposed by the design of the present study and relatively low number of participants.

Despite the significant variance, there is a clear trend in the relative position of point clouds of different colors.

Overall, the pressure subsystem evaluation values exhibited an increasing trend.

This was the case with the SARS outbreak in 2003, where an increasing trend in fatality rate is suggested by the CFR estimator but in fact, it was a false alarm caused by the way of calculating 6 .

Correlations ranging from moderate to quite significant were found between the value of the alpha angle and the width of the forefoot as well as the values of the indices reflecting the height of the transverse arch of the foot: the Wejsflog index and the gamma angle (Table 5 ).

If their values are 0.9 or greater, the model is regarded as adequate and highly significant, however, R 2 should not be lower than 0.75 52 , 53 .

In the present study, the comparison of metabolic health status components between tertiles of dairy intake showed that blood pressure values (SBP and DBP) had no significant difference across tertiles, while others factors including TG, HDL-c, and insulin levels had marginally significant differences across tertiles.

According to our findings, grain yield and biomass showed an increasing trend due to both N and NI applications.

Besides, a trend towards significance was also shown for apple, while no difference was found for jasmine and durian.

However, if PSE saturates or declines with greater object speed, then SOS 3 is more likely to be significant.

Among males, there was a significant trend for younger males to use it exclusively for foraging.

If there is no significant change of signal levels across each specimen dilution, the sample is considered to be R and moves onto the next step; if there is a significant drop in signal levels and/or a decreasing trend in either specimen dilution, the sample is reported S.

Probands harboring rs363538 ‘CC’ genotype showed a trend for improvement in the trait scores (Fig. 1 e–h) with a significant impact on the IA score (Fig. 1 f).

The primary limitations of the present study are (a) the analysis of GRIK1 mRNA expression in only a limited number of samples and (b) marginally significant associations between the studied genetic variants and ADHD, as is evident from the close to significance p-values, low relative risk, and power of the association tests.

Any effect that extends beyond the chart's reference line is highly significant.

Most studies have stated that there is a marked trend towards acidification, beginning with an acidic pH of 4.5 to 6, with a desired value of 5 62 .