Excerpts

A multivariate test of differences between SLE and control subjects based on the first six PCs was highly significant (p < 10 −15 ), as was the test based on only the first PC (p < 10 −15 ).

Analysis of the number of crystal packets among the studied species revealed highly significant differences in their frequency of occurrence (ANOVA, p < 10 − 15 ).

There was a highly significant interaction for both DCV and FHV (Cox's mixed-effect models; DCV: χ 2 = 127.4, d.f. = 19, P <10 −15 ; FHV: χ 2 = 107.6, d.f. = 19, P <10 −14 ).

Not surprisingly, all pairs of correlations are highly significant with p -values < 10e-16 (alternative hypothesis: true correlation is not equal to 0).

While there is a highly significant correlation between PC1 for both methods ( R 2 = 0.949, p < 1 × 10 −15 ), later PCs are often not significantly correlated, with the most notable exception being EFD PC2 and PH PC3 ( R 2 = 0.432, p < 1 × 10 −15 ), although several other PCs also show weak correlations.

Analyzing the AMΦ data with linear models to control for batch effects, we found a highly significant effect of CSE concentration (p < 10 −15 ) on phagocytosis.

Comparing between a paper’s date of publication and its citation count reveals there is a low anti-correlation (−0.2) but highly significant between the two (Pearson product-moment correlation test P -value < 10 −15 , Supplementary Fig.

A massive and highly significant ( p -value <10 −15 ) decrease of TAT expression is observed in tumors as compared to their adjacent tissue in most of the samples (87/112, median decreased of 20 fold, Fig. 6 ).

Transcriptomic analysis of differentially expressed genes following cannabis or tobacco smoke exposure for 24 h at 10% dilution revealed a highly significant correlation ( r = 0.695, P < 1.0*10 −15 ) and overlap of shared changes in gene expression (Fig. 1 , n = 389, purple triangles).

This overlap is highly significant (p < 10 −15 , hypergeometric distribution), indicating that CUT&RUN correctly recovers a large portion of previously identified R-loops.

S8 D and E ), and the association was highly significant in both strains, P tet lacZ ΔM15 ( P < 1 × 10 −15 ) and P tet lacZ ΔM15 ssrA ( P < 2 × 10 −3 ).

The 737 shared downregulated genes were enriched in GI pathways ( Figure 3E ), and this overlap was highly significant by hypergeometric test ( P < 1 × 10 –15 ; ~5-fold enrichment) ( 65 ).

We also found that the interaction term was highly significant ( P < 10 −15 ), indicating that the effect of the HULK genes on flowering time was non-additive (i.e. epistasis was apparent).

1d ) fitted the standard logistic population growth model well and displayed highly significant increase in biomass ( p < 10 –15 , likelihood ratio test), which is typical for the growth of microorganisms under favorable conditions 23 .

The overlap of DTA and DGE events identified across all three data sets was highly significant (phyper P < 1 × 10 −15 ), confirming the robustness of our findings.

Similarly, we found slightly reduced but still highly significant correlations using expression differences normalized to the average variation (effect size) (Pearson's correlation R = 0.566, p < 10 -15 and R = 0.584, p < 10 -15 , respectively).

The enrichment of functionally characterized sites within the group of AcP‐insensitive sites is highly significant ( p = 1e −15 , Fisher exact test).

In the case of pairs corresponding to Cluster II, there was a clear inverse relationship between ω and t , with a highly significant statistical correlation ( r = -0.9032, P < 10 -15 ).

Of 17,566 detected genes, we identified 1,080 highly significant differentially expressed genes upon viral stimulation (p<1.00E −15 , FDR<1.00E −14 ), including various immune function and inflammation-related genes, genes involved in cell signaling, cell regulation and transcription, and genes with unknown function.

We observed highly significant ( P < 1 × 10 −15 , binomial test) enrichment of conserved miRNA binding sites among genes that currently share experimental evidence for neural 3′ UTR extensions in both mouse and human ( Fig. 7B ; Supplemental Table S7).

Highly significant positive correlations (p<1×10 −15 , Pearson’s correlation) were found between the HG-ST1.0 and HG-Focus microarray values.

Student's t-test analyses show highly significant differences in the overlap of p12 with chromosomes between mitotic and interphasic cells for the 1xMycR virus (p<10 −15 ); similarly highly significant differences in the overlap were observed amongst the 1xMycR or 1xMycR/PM14 viruses in mitotic cells (p<10 −17 ); and an absence of such differences for either the two viruses in interphasic cells or for the 1xMycR/PM14 in mitotic and interphasic cells (p>0.4).

Interchromosomal locus-locus contacts The interchromosomal contact frequencies in the structure population are correlated with those observed in experiments, with an average Pearson's correlation of 0.54, which is highly significant ( P < 10 −15 ) ( Fig. 3E,F ; Supplemental Fig. 2D).

We have to reject the null hypothesis and this result is highly significant ( p < 10 −15 ).

We found a highly significant correlation between promoter CpG O/E and 3' UTR length (Spearman's ρ = 0.24; P < 10 -15 ), indicating that the negative correlation pattern between promoter region methylation and number of miRNA target sites still holds in mice.