Excerpts

Moreover, our analyses revealed highly significant spatial autocorrelation among sampling locations in species richness (Moran's I = 0.230, p < 10 −15 ), Shannon diversity (Moran's I = 0.128, p < 10 −5 ), and Simpson diversity (Moran's I = 0.085, p = 0.001).

A multivariate test of differences between SLE and control subjects based on the first six PCs was highly significant (p < 10 −15 ), as was the test based on only the first PC (p < 10 −15 ).

This module includes 44 DEGs, which is a highly significant enrichment (Fisher’s exact test, Odds ratio = 75.84, P < 10 −15 ).

While we estimate that this stringent quality control produced well calibrated association test statistics for more than 99% of sites, this analysis yielded many extremely significant p-values at SNPs outside of known loci (e.g. ~7,000 with p < 10 -15 ), 95% of which had an allele frequency below 5%.

This is clear from gene ontology (GO) analysis of the genes associated with HOT regions: Categories such as ‘metabolic process’ and ‘cellular component biogenesis’ are highly significant (both P < 10 −15 ).

S8 D and E ), and the association was highly significant in both strains, P tet lacZ ΔM15 ( P < 1 × 10 −15 ) and P tet lacZ ΔM15 ssrA ( P < 2 × 10 −3 ).

Analyzing the AMΦ data with linear models to control for batch effects, we found a highly significant effect of CSE concentration (p < 10 −15 ) on phagocytosis.

The test revealed a highly significant ( P = 1 × 10 −15 ) association between district and C. parvum subtype ( χ 2 = 85.09, df = 8, P < 0.001).

Due to large sample sizes, all obtained P values for context/subcontext comparisons are highly significant ( P < 10 −15 ) for all observations mentioned in our study.

Quantification of glial nuclear basket ::GFP levels normalized to the oil vehicle control (1.0 ± 0.029, n = 13; 10 nuclei averaged per data point) shows a highly significant ~ 200% mean nuclear elevation following critical period EB experience (1.904 ± 0.030, n = 17; t (28) = 21.24, p < 1.0 × 10 −15 , two-tailed unpaired t- test; Fig. 5 B).

We find a highly significant negative correlation between the two measures (linear regression: R 2 =0.34, P <10 –15 ), which is illustrated in Fig. 4 .

The baseline method ROTS that ignores longitudinal trends also performed well with an IQR mean pAUC of 0.941, while the difference to the best performing method RolDE was highly significant ( p < 10 −15 ).

We observed a highly significant increase in DFI with increasing age ( ρ = 0.57; p = 1.04 × 10 −15 ; Figure 1b ).

The eGWAS peak SNP was detected approximately 9 kb upstream of OsENT1 with a highly significant signal (− log P = 14.97) and was located within 50 kb of the GWAS peak SNP responsible for NRT_L (Fig. 3 A).

Results for lung cancer overall are less significant after PC adjustment, but there is still a highly significant result for the ATM −2307F association in LUAD ( P = 1.18 × 10 −15 for discovery and P = 2.22 × 10 −3 for replication (Table 1 ).

We found, for H3K4me1, a highly significant enrichment for blood u-tDMRs (mean: 9.7; P -value = 1.2 × 10 −15 t-test) and liver f-tDMRs (mean: 9.3; P -value <2.2 × 10 −16 ; t-test for regions with methylation difference <0).

[ 12 ] also showed a strong and highly significant association between SMPD1 variants with ≥ 56% loss of enzymatic activity and PD risk (OR 2.24, p = 1.25 × 10 -15 ).

When we tested the association between SOX2 positivity and RAD51 expression, we found it to be highly significant (p = 1.28 × 10 −15 ), suggesting a correlation between RAD51 expression and the putative self-renewing fraction ( Figure 1 F).

the effect was much stronger than that of the two individual metabolites (Table 4 , ESM Table 19 ; both p ≥ 2.2 × 10 −16 , p gain = 2.2 × 10 11 ). Fasting pairwise metabolite ratios at baseline and incident type 2 diabetes Meta-analysis of the Cox regression results in two independent prospective studies (910 individuals with incident type 2 diabetes and 3367 control participants), with adjustment as shown in ESM Table 10 , shows a highly significant association between the ratio of valine to PC ae C32:2 and type 2 diabetes susceptibility (Table 5 ; HR Val_PC ae C32:2 1.57 [β 0.45 ± 0.06], p = 1.3 × 10 −15 ; the results for the crude models are shown in ESM Table 20 ).

All loci produced highly significant linear regression models (maximum P -value = 1.3 × 10 −15 , minimum R 2 = 0.11).

Three highly significant pathways were identified by the Reactome analysis of these protein clusters: The citrate (TCA) cycle pathway ( p = 1.33 × 10 −15 and FDR = 3.46 × 10 −14 ), the mRNA metabolism/catabolism pathway ( p = 7.96 × 10 −8 and FDR = 3.60 × 10 −6 ), and the unfolded protein response pathway (UPR; p = 2.04 × 10 −13 and FDR = 1.35 × 10 −11 ) ( Figure 9 d). 3.3.

There was also a highly significant relationship between gender and the number of English-language publications (Kruskal–Wallis chi-squared = 68.37, p < 1.42 × 10 −15 ) and between disciplines and the number of English-language publications (Kruskal–Wallis chi-squared = 29.45, p < 6.35 × 10 −6 ).

Fisher’s exact test demonstrated highly significant enrichment of current FDA-approved psoriasis biologics at both D1 ( Figure 2 d) and D2 (data not shown) ( GSE54456 : P = 1.42E-15 and 9.62E-7, respectively; GSE121212 : P = 5.13E-12 and 1.56E-6, respectively).

While we did observe multiple cis -eQTL genes for some top candidate SNPs, such as rs73551707, these were nominally significant compared with the nearest target gene, BMP1 ( P =1.45E−15 in aorta; 1.10E−14 in mammary artery; Supplementary Fig. 19 ; Supplementary Data 12 ).

On the contrary we found a mild (1.98%) but highly significant ( P -value = 1.5 × 10 −15 , paired t -test) decrease in the average occupancy at nucleosome +1 in AGO2 knock-down cells (data not shown).