We observed that the tumor types with highly significant KDM7A-DT gain and amplification were highly aggressive, including hepatocellular carcinoma ( p = 8.8E-13), pilocytic astrocytoma ( p = 3.43E-10), melanoma ( p = 5.21E-10), prostate adenocarcinoma ( p = 5.16E-08), medulloblastoma ( p = 4.20E-07), and colorectal carcinoma ( p = 6.14E-04).
Excerpts
Conversely, the variety has a very highly significant effect ( p = 9 × 10 −13 ) on the intercepts of these relationships.
There was a significant trend of positive correlation between the risk score and the angiogenesis activity score (R = 0.32, p = 9.5e−13) (Fig. 7 J).
The genotypes (RIL and accession) had a highly significant effect in both populations ( P -values ≤ 9.92e−13).
In our HSA14 simulations, the presence of heterochromatin slightly reduces the absolute value of the correlation, which however remains highly significant (Spearman correlation r ≃ −0.83, p < 10 −12 ).
Indeed, we found the correlation between rankings of two reported lists was positive (Spearman’s correlation coefficient ρ = 0.68) and highly significant (p value < 10 −12 ).
A linear regression of the first principal component (PC1, explaining 20% of the functional variance) and the relative abundance of the Bacteroidetes showed a highly significant correlation (R 2 =0.96, p<10 −12 ; Fig. 2B ).
Notably, a highly significant enrichment of RGAC motifs at NKAP-binding footprints (CIMS or CITS along with a 5-nucleotide flanking sequence) was identified by iCLIP-sequencing ( P < 10 −12 , Wilcoxon rank-sum test, Fig. 5g ), suggesting that NKAP preferentially binds the m 6 A core motif RGAC.
We found a highly significant ( p < 10 −12 ) positive ( R 2 > 0.51) correlation between levels of expression of 2071 transcripts whose expression was affected by both stimuli.
Gene pathways up-regulated by age in all three tissues were complement genes, apoptosis and interferon gamma response pathway genes, albeit this upregulation was highly significant (hypergeometric test, p < 10 −12 – 10 −20 ) in the old kidney and less significant in the old liver and skeletal muscle ( Figure 2 ).
The overrepresentation of mutations in subtelomeric regions is highly significant in O. tauri (10 vs. 94 mutations in subtelomeric versus nonsubtelomeric regions, Fisher exact test, P -value <10 −12 ), B. prasinos (8 vs. 24 mutations, Fisher exact test, P -value <10 −12 ) and M. pusilla (4 vs. 81 mutations, Fisher exact test, P -value <10 −4 ).
The general lack of diagnostic specificity is also apparent in the Spearman's rank correlations (Table 4 and Supporting Information Tables 2 and 3), as for each pair of diagnoses, correlation coefficients across regions ranged between 0.42 and 0.82 and were highly significant (0.001 < P < 10 −12 ).
There was also a highly significant correlation between expression of various B- and T-cell signatures and expression of the immune checkpoint gene TIGIT ( r = 0.80, p = 1,0e-12 and r = 0.91, p = 1.8e-21 respectively) ( Fig. 4 H).
9B ) shows functions related to “Cellular Movement, Hematological System Development and Function, Immune cell trafficking and cell-mediated immune response”, with a highly significant score of 12 (p = 10 −12 ) (Fig. 9 ).
Results The differences in the distribution of SE between the wake and N2, and wake and N3 were highly significant ( p < 10 − 12 for both comparisons), whereas the difference between the wake and REM states was not ( p = 0.12 ).
Because this method allowed for the simultaneous quantification of many peptides per protein, the changes induced by both cell treatments were found to be highly significant ( P < 1 × 10 −12 and P < 1 × 10 −29 for eIF4G and eIF4A, respectively).
The TPT main effect was highly significant regardless of the data set used (full data set: F 10,370 = 37.6, p<1×10 −12 ; limited data set: F 10,370 = 30.7, p<1×10 −12 ), clearly indicating the significance of the online compensatory adjustments of F1 in response to the AF perturbations when the data were collapsed across the two groups of subjects.
The survival difference is highly significant (log-rank p < 10 −12 , hazard ratio = 1.72, 95% CI: 1.58–1.89), annotated in the upper right of the panel.
We also found a highly significant main effect of cluster ( F (6, 247.48) = 237.58, p < 10 −12 ), showing that different neural clusters had distinctive baseline activity levels.
An unanticipated outcome was the finding of a highly significant (p < 1 × 10 −12 ) relationship with up- and down-regulated genes encoding effectors of the DNA damage response, including BRCA1 , CHK2 and RAD51 , among many others (Supplemental Fig.
Pearson correlations with PC[1] scores were highly significant ( P < 10 −12 ) for height ( R , 0.65), yield ( R , 0.56) and growth rate ( R , 0.62).
To test this more formally, we assessed baseline pupil size in our a priori baseline time window −1 to 0 s and found a highly significant difference in pupil size preceding certain vs. uncertain choices ( β C > 0 , t = 6.9 , p ~ 10 − 12 , CI = 0.03 , 0.05 ) (Figure 2A , inset bar plots).
Furthermore, analyzing the sample similarity based on these cluster frequencies resulted in highly significant grouping of samples with the same diagnosis ( P < 10 −12 ; Fig. 3E ).
Of the 119 genes that were both represented in the MCF-7 dataset and increased in EGFR -mutant NSCLC cells, 44 (31%) were increased with P <0.05 in EGFR -transfected MCF-7 cells, which represented a highly significant overlap ( P <1E–12, one-sided Fisher's exact test, Fig. 2 E ).
The difference in substitution scores between core and surface region is highly significant for both SVD and CSM ( P <1.0 −12 ) and significant for SVP ( P <1.0 −4 ), whereas it is not significant for SAP ( P <0.78).