Excerpts

Of the 119 genes that were both represented in the MCF-7 dataset and increased in EGFR -mutant NSCLC cells, 44 (31%) were increased with P <0.05 in EGFR -transfected MCF-7 cells, which represented a highly significant overlap ( P <1E–12, one-sided Fisher's exact test, Fig. 2 E ).

In this ANCOVA the effect of phenotype is not significant ( P = 0.09) while expression level is highly significant (P<10 −12 ).

The TPT main effect was highly significant regardless of the data set used (full data set: F 10,370 = 37.6, p<1×10 −12 ; limited data set: F 10,370 = 30.7, p<1×10 −12 ), clearly indicating the significance of the online compensatory adjustments of F1 in response to the AF perturbations when the data were collapsed across the two groups of subjects.

A linear regression of the first principal component (PC1, explaining 20% of the functional variance) and the relative abundance of the Bacteroidetes showed a highly significant correlation (R 2 =0.96, p<10 −12 ; Fig. 2B ).

9B ) shows functions related to “Cellular Movement, Hematological System Development and Function, Immune cell trafficking and cell-mediated immune response”, with a highly significant score of 12 (p = 10 −12 ) (Fig. 9 ).

When we applied Fisher's exact test to gene sets identified by the different approaches ( Supplemental Figure S3A–C ), we always found highly significant overlap (more genes in common than expected by chance) between the SB Driver Analysis and GKC analysis methods ( P < 10 −12 ).

The DEG group with stress-induced downregulation (blue) demonstrates a highly significant ( p < 10–12) positive correlation between PC1 and PC2.

The enrichment of NO‐related genes in the differentially expressed genes was statistically extremely significant (chi‐squared test, P < 10 −12 ).

CC15 exhibited highly significant associations with both ant(4’)-Ia and lnu(A) ( P = 1.01E-12, OR = 583.8 for both).

A chi‐squared test confirmed a highly significant association between vector construct and co‐transformation frequency ( χ 2 (3) = 58.87, P = 1.03 × 10 −12 ).

A statistical analysis using the chi-square test of independence revealed a highly significant difference between the groups (χ 2 ≈ 43.6; P < 1.04 × 10 –12 ), confirming that a full stomach exerts a protective effect on the pars oesophagea and significantly reduces the risk of ulcerations.

Indeed, of the 1,734 KHSRP targets identified in Winzen et al, 43 245, or 14%, overlapped with the 1,589 ischemia-stabilized mRNAs, an overlap that was highly significant via normal approximation of exact hypergeometric probability (Representation factor: 1.5, p < 1.064e −12 ).

Results: A highly significant association with CD was observed, with the strongest signal at coding variant Arg381Gln (allele frequency, 2.5% in CD vs 6.2% in controls [ P = 1.1 × 10 −12 ]; odds ratio, 0.38; 95% confidence interval, 0.29–0.50).

Furthermore, a hypergeometric test indicated that the identification of 18 seasonal genes out of 363 may have occurred by chance ( p = 0.4233), whereas the 87 vitamin D target genes among the 873 circadian genes were highly significant ( p = 1.1976 × 10 −12 ).

Identification of genes differentially methylated between PCNSL and hematopoietic controls PCA based analysis applying most stringent conditions differentiates normal controls from both PCNSL and systemic DLBCL samples in a highly significant fashion (p = 1.2 × 10 -12 , q = 3.9157 × 10 -11 ; Fig. 1A ). 33 CpG loci (corresponding to 30 genes) differentiating between PCNSL and controls performed in replicates were significantly hypermethylated while three CpG loci showed hypomethylation in PCNSL compared to hematopoietic controls (Fig. 1B ).

For heat resistance (CTmax), males became less tolerant with increasing age as we observed a significant negative slope with age in the regression (p = 7.91e-23), whereas for females, their resistance to heat is not changed with age suggested by the highly significant positive interaction effect (p = 1.20e-12) (Table 1 , Fig. 1B ).

Network enrichment analysis revealed a highly significant functional network (19 nodes, 29 edges; PPI enrichment p = 1.3e-12), with TNF emerging as the central hub ( Supplementary Figure 3G ).

The C-786 mutant group, however, was more common in Caucasians (14.5%) compared to Africans or African Americans (3.2% and 1.8% respectively) and this difference was highly significant (χ 2 = 61.64; P = 1.312 × 10 −12 ).

A highly significant, negative correlation was also observed between this DMR and MAB21L2 (r = −0.66, p = 1.35 × 10 −12 ), but not LRBA .

For example, Lee et al reported a comprehensive HCC gene signature on a Chinese-Belgium dataset that overlapped our results in a highly significant manner (4.8 fold enrichment; Fisher Exact Test p-value = 1.4E-12 for the tumor tissue DFS signature, Table 1 and 2 ).

Tdrd7 was differentially transcribed between tissues, with a moderate but highly significant upregulation in the gonads (~ 2.5 times more transcribed considering pooled sexes; p -value = 1.4e−12).

Genotype analysis of 168 pups at weaning revealed that only two Tbx1 +/– ;Pax9 +/– mice were alive, a highly significant deviation from the 42 expected of each genotype from this cross ( P =1.4×10 −12 ; Table S2 ).

Interestingly, we observed a highly significant decrease in mtDNA copies in the SS patients compared to healthy controls ( p = 1.44 × 10 −12 ).

Notably, we obtained highly significant ORs for rs7903146, including the pooled OR for the T allele versus the C allele (OR = 1.54, 95% CI: 1.37 – 1.74, p = 1.47 × 10 -12 , I 2 = 25.20%) and the OR for heterozygotes versus C homozygotes (OR = 1.56, 95% CI: 1.38 – 1.76, p = 8.25 × 10 -9 , I 2 = 21.00%) (Figure 3 ).

For grain Na + content we observed a single highly significant association on the bottom of chromosome 4HL for the marker SCRI_RS_142792, with a −log10(p) = 11.8, FDR adjusted p -value = 2.2E-08, and an R 2 = 0.45 (Fig. 1b ) consistent with prior genetic analyses of shoot Na + content 19 – 21 .