Barely Significant

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a significant trendp < 0.0010.0× alphagold
There was a significant trend of an increasing symptom score and headache frequency, for both age groups with respect to anxiety and depressive symptoms (12–14 years, p < 0.001 and 15–17 years, p < 0.001) and attention difficulties (12–14 years, p < 0.001 and 15–17 years, p = 0.008), but not with conduct difficulties.
highly significantp < 0.0010.0× alphaqualifiedgold
Patients with sustained improvement achieved a 41.5 μmol/L decrease in creatinine concentration at 3 months, whereas patients with deterioration showed only a 7.5 μmol/L reduction, indicating a highly significant difference ( p < 0.001) ( Table 4 and Figure 2 ). 3.6.
an increasing trendP < 0.0010.0× alphagold
Similarly, there was an increasing trend in the total PQ base dosage administered (242.6 ± 79.7 vs. 265.7 ± 92.3 mg, P < 0.001), despite no significant differences in total weight-based PQ base dosage administered (3.38 ± 1.1 vs. 3.64 ± 1.3 mg/kg, P = 0.256) or the proportion of patients in the underdosing group (< 3.5 mg/kg; 296 [73.6%] vs. 167 [68.2%], P = 0.135] between the two periods.
a decreasing trendP <.0010.0× alphagold
Although both the intervention and control groups showed a decreasing trend in sleep latency at posttest (intervention: adjusted mean difference −27.80 minutes/day, 95% CI −33.07 to −22.53, P <.001; control: −26.05 minutes/day, 95% CI −31.22 to −20.89, P <.001) and follow-up (intervention: −26.63 minutes/day, 95% CI −32.05 to −21.20, P <.001; control: −18.43 minutes/day, 9
highly significantp < 0.0010.0× alphaqualifiedgold
Host taxonomic group and health status were not significant drivers within-site, and the only significant factor was site itself, which was highly significant for both the abundance data ( F 13,98 = 2.93, p < 0.001) and the presence/absence data ( F 13,98 = 2.92, p < 0.001); Fig. 1A plots the site data onto the first two axes of the NMDS for the abundance data, highlighting in colour sites 1, 5, 6, 8, 9 and 10 which have markedly different ordinations compared with the rest of the sites.