Excerpts

p-values were all highly significant (p < 0.001) for comparisons of 27°C vs. 23°C and 31°C vs. 27°C (each a 4°C increase), as well as for 31°C vs. 23°C (8°C increase, Additional file 9 : Table S7).

Moreover, the fraction of tumoral dendritic cells component was significantly (highly significant in dendritic cells resting (HR = 0.4 (0.23–0.69), p < 0.001) and marginally significant in dendritic cells activated (HR = 0.56 (0.30–1.04), p value = 0.067)) and positively associated with poor prognosis, suggesting a deleterious effect on clinical outcome, whereas a totally opposite beneficial effect was observed in peritumor samples (dendritic cells resting [HR = 1.97 (1.27–3.06), p value = 0.003]; dendritic cells activated [HR = 2.92 (1.07–7.98), p value = 0.037]) ( Figure 5 B).

affected by pruritus had been significantly reduced after treatment; duration − 1.5 (95% CI − 1.7, − 1.3; p < 0.001), indicating that patients transitioned from being bothered by pruritus for up to 18 h per day to a maximum of 6–12 h per day; degree − 1.3 (95% CI − 1.4, − 1.1; p < 0.001), implying a significant trend from moderate/severe to mild pruritus; and direction − 1.7 (95% CI − 1.9, − 1.6; p < 0.001), indicating a significant improvement in pruritus when compared with baseline (Table 2 ).

For AIE lesions, all comparisons showed highly significant differences ( p < 0.001) with moderate to large effect sizes (Cohen’s d: 0.6–2.9).

Test of trend across scores was highly significant ( P < 0.001).

lactis as main effects, but their interaction had a highly significant (p > 0.001) effect.

The difference between the non‐functionalized and the two functionalized hydrogels was highly significant ( p < 0.001).

The negative buffering effect of diversity on variability across the gradient was similar in microorganisms and macroorganisms (similar slopes, ANCOVA interaction: P = 0.71), and a single linear fit across both microorganisms and macroorganisms was highly significant (CV = 156–71.1 logS, R 2 = 0.58, P < 0.001; Supplementary Information: Fig.

The difference of 9.1% in the SVR rates between the ≥ 25% and < 25% overreporting levels was highly significant ( p <.001).

The TyG index measured 8.82 ± 0.51 in non-dippers while dippers had an average of 8.51 ± 0.42 which produced a highly significant result ( p < 0.001).

The in vivo data were highly significant (p<0.001) according to the chi-square test.

However, for international collaborations outside South America, there was an increasing trend over the years (p < 0.001).

In the young cohort (<30 years), IF provoked a substantial and highly significant increase in LDL-C (MD = 6.75 mg/dL, 95% CI [3.15, 10.34], p < 0.001, Supplementary Figure S32 ).

As shown in Table 4 , the regression model is highly significant (P < 0.001) with respect to LMP yield, while the misfit term (P > 0.05) is not significant, suggesting that the model is appropriately designed.

The corrected R 2 = 0.019 was small but highly significant ( p < 0.001).

Progressing from No-DR to S-NPDR, there was a significant trend of worsening visual acuity (logMAR BCVA P < 0.001) and thinning of the choroid (SFCT P < 0.001).

MV130 was associated with a highly significant reduction in the total number of infectious episodes in both children and adults with URTIs or LRTIs ( Figure 2 A,B, Table 2 and Table 3 ) ( p < 0.001).

This trend was highly significant (τ = 0.73, p < 0.001), accompanied by a moderate but significant expansion in range (τ = 0.35, p = 0.005; Fig. 2 ).

MMEx at 200 mg.kg −1 achieved a highly significant ( p < 0.001) inhibition of BSA denaturation of (58.27 ± 0.19%) in a dose-dependent manner.

Though the correlation was overall still highly significant between Step-wise and Simultaneous models (L-TLE, rho = 0.58, P < 0.001, R-TLE, rho = 0.55, P < 0.001), all Step-wise correlations in the L-TLE versus R-TLE task were significantly lower than in the HC versus TLE task (all Fisher’s Z s > 10.5, P s < 0.001).

Children using control medications including inhaled corticosteroids (ICS), long-acting beta2-agonists (LABA), leukotriene receptor antagonists (LTRA) and tiotropium bromide demonstrated moderately significant correlations with better asthma control ( r = 0.615, p < 0.001) and improved HRQoL scores ( r = 0.676, p < 0.001) (Table 3 ).

This difference was highly significant ( p < 0.001, n = 7) and provides compelling evidence that H 2 S causes a substantial Ca influx in type 1 cells.

Intraocular Pressure Dynamics Repeated-measures ANOVA revealed a highly significant main effect of time on IOP [F(1.8, 70.2) = 312.5, p < 0.001, partial η 2 = 0.89].

The adjusted model was highly significant ( p <0.001) but explained only 3.5% of the variance in the outcome measures.

It was observed that piliated E24337a produced highly significant (P< 0.001) biofilm compared to non piliated E24337a strain.