Excerpts

Rearing events also showed significant or near-significant increases when analyzed separately within binned intervals (0 to 10 min, P = 0.002; 10 to 20 min, P = 0.046; 20 to 30 min, P = 0.074) ( Fig. 3 C ).

Only one variant (rs999741 in the HTR4 region, MAF 26%) had a nominally significant P-value (P = 2x10 -3 ) and had consistent direction of effect in stage 1 and stage 2 ( S4 Table ).

The same was true for the EPITARGET dataset, where all factors were highly significant ( p < 0.002).

Crucially, the interaction of congruency and task was highly significant, F (1, 46) = 10.80, p = 0.002.

In the stratified analysis, the risk was higher in each subsequent quartile, with a significantly higher risk in the fourth quartile in comparison to the lowest quartile (HR: 1.39, 95% CI; 1.12–1.72), with a significant trend over the quartiles ( p ‐value = 0.002, see Table 3 ).

Furthermore, an elevated white blood cell (WBC) count demonstrated a highly significant association with appendicitis (p = 0.002), occurring in 18.6% of appendicitis cases versus 33.3% of non-appendicitis cases.

For men, we found a highly significant association with 95% CIs ranging from 0.04 to 0.48 ( p = 0.002), while for women, 95% CIs ranged from 0.40 to 2.71 ( p = 0.938) (Table 2 ).

A forest plot ( Figure 3 a) from three studies (MED range; 1.0–2.5) of oral intake studies with healthy participants ( n = 175) revealed a highly significant pooling difference ( p = 0.002) in pre-and post-intervention changes in erythema index (SMD: −0.35; 95% CI, −0.57 to −0.13; I 2 = 4%, p = 0.40) in the random-effects model.

A borderline significance of the same compound genotype was also detected between the two control groups of EBV/IgA/VCA negative vs. positive individuals (OR = 0.25, p = 0.002).

However, the highly significant correlation between root resorption and the presence of inclusion ( p value=0.002), in agreement with the literature, demonstrates a real risk of resorption in the case of inclusion of the maxillary canine.

Furthermore, with a trend toward significance, the distribution of mGluR 5 receptors overlaps with the rs‐FC modification of Crus I ( R = 0.775, uncorrected p = 0.002, SA‐corrected p = 0.02) and Vermis IV‐V ( R = 0.420, uncorrected p = 0.003, SA‐corrected p = 0.051).

The size difference between DWI and MTT lesions was highly significant ( p = 0.002), confirming an inverse mismatch between hypoperfusion and infarct.

Both current smoking rate and cessation rate remained to be highly significant even after controlling for age, education, occupation, and living apartment (p = 0.002 for current smoking rate and p = 0.004 for cessation rate).

In addition, we found that patients with high levels of C9orf86 expression showed a significant trend towards worse survival compared to patients with low C9orf86 expression (P = 0.002).

At 3 months, PPD changes were −1.46 mm for the test quadrants and −1.25 mm coming very close to statistical significance (p = 0.002) with a further improvement to −1.74 mm in test quadrants and −1.55 mm in the control quadrants at 12 months with p values still not significant.

For the 60-meter sprint, the mean time for females improved from 8.72 s to 8.63 s, a highly significant change (t = 3.889, p = 0.002), and the mean time for males was found to have decreased from 7.68 s to 7.58 s (t = 4.281, p = 0.001).

We previously reported that constitutive overexpression of asTF in PT45.P1 cells induces MAPK and Akt phosphorylation [ 7 ]; in this study, MAPK p42/44 phosphorylation levels were unaffected by RabMab1 treatment (data not shown), yet a highly significant decrease in pAKT-T308 was observed ( p = 0.002), while the levels of pAKT-S473 were unaffected (Figure 5C ).

There was a highly significant negative correlation between patients’ body mass index (BMI) and the proportion of patients with ≥12 lymph nodes examined (correlation coefficient r = –0.679, P = 0.002), but no such association was found for the absolute node count (correlation coefficient r = –0.056, P = 0.349).

This result is highly significant ( P = 0.002) and reliable as the CI is relatively narrow.

Annually, the proportion of patients with good neurologic outcomes showed an increasing trend for the manual chest compression group (P=0.002), but a plateau was observed in the mechanical compression group (P=0.598) ( Fig. 2A ).

Multivariable Cox regression analysis showed that chromogranin A level and MTV together were highly significant predictors of therapeutic outcome (HR 2.67; 95% CI 1.41–4.91; p = 0.002).

The positive correlation for subgroup C ( r C = 0.510, N = 33) ( Table 3 ) indicated a highly significant increase in network variability with age (P = 0.002); in contrast, that correlation in subgroup D was negative ( r D = − 0.143, N = 10) but not statistically significant (P = 0.693).

In contrast, the BP slope in the IH patients showed a trend towards a decrease with each hour (−0.3 mmHg/hr) during the first 24 hours, and this change was different from not only the same time period in controls (p=0.002, Figure 1 ), but also when compared to hours 25–44 in the IH patients (p=0.001).

Although, as above, there was no effect in saturation values ( F (1,109) = 1.596, p = .209), there was a highly significant effect in luminance ( F (1,109) = 9.708, p = .002).

A highly significant negative correlation was found between serum vitamin D level and each of CRP and serum ferritin ( r = − 0.346 and − 0.313) ( P = 0.002 and 0.005).