Excerpts

However, differences between DFS, OS and CSS for the two age groups remained highly significant when only those patients treated since 1990 were analysed ( P =0.004, <0.001 and <0.001, respectively).

This generalization decrement was highly significant (Wilcoxon matched-pairs test, T = 0.0, p = 0.004).

The difference of CXCL10 median plasma concentration among T1R and their matched controls was highly significant (p = 0.004) (Fig 1A ).

The tests for nonlinear association between serum cystatin C and MACE in patients with ACS after PCI were highly significant (P=0.004).

Finally, a marginally significant interaction gender × incentives resulted from analyses [ F (3.220, 2154.115) = 4.368; p = 0.004; η p 2 = 0.006].

Univariate analysis shows a highly significant survival difference in favour of the HRT-treated group ( P =0.004).

Over time, the young age group showed a trend towards better global health, in contrast to the oldest group, which showed a trend towards worse global health ( P =0.004).

Urine sodium of 130 mmol/L or greater was the most highly significant predictor of nonresponse to FR (OR 15.0; 95% CI, 2.4-95.8; P = .004) and while the closely-related Fürst ratio greater than 1 also predicted nonresponse, it performed less well (OR 2.7; 95% CI, 1.0-7.6; P = .05).

The individuals living in Cochran and Bailey Counties had high likely to have cognitively impaired (AOR: 1.807, 95% CI: (0.749, 4.360), p = 0.188; AOR: 1.674, 95% CI: (0.267, 10.489), p = 0.582) though the adjusted odds ratios are not statistically significant, on the other hand Parmer County had the highest cognitively impaired individuals (AOR: 39.188, 95% CI: (3.123, 491.671) and this adjusted odds ratio is statistically highly significant ( p = 0.004).

As Kadi et al showed in their review, the effects of satellite cell activation take approximately 50-90 days to propagate fully, which corresponds to our 2-month follow-up observation, when the increase of muscle fibers was found to be highly significant when compared to the control group ( P value = .004). 35 Nonetheless, all markers increased gradually in the active group and no significant changes were observed in the control group, and we can attribute the results seen in the active group to the HIFES + RF sessions.

Correlations between CRP and IL-6 were moderately significant and positive ( r = 0.446, p = 0.004) ( Figure 4A ).

Interestingly, co-treatment with NAC and SMC had a synergistic effect, producing a highly significant reduction compared to the PD group ( P = 0.004), with a significant difference.

PERMANOVA based on the Bray-Curtis distance showed that the treatments had a highly significant effect on the structure of functional gene communities ( R 2 = 0.927, F = 38.33, p = 0.004).

A highly significant ( p = 0.004) PCT concentration demonstrated it to be a clinically meaningful effect size and a reliable biomarker in discriminating the progression of TBI post 72 h, with an AUC of 0.834 at 72 h and 0.607 at 24 h from the admission time.

We found that both tests were more likely to be significant colocalisations if they were from the same cell type compared to different cell types (odds ratio = 1.2, p = 0.004).

Assessment of the duration of the recruitment period showed a trend for longer durations in elamipretide treated cells, with 0.01 μM elamipretide yielding significantly longer times relative to vehicle treated cells (Fig. 2 D; P = 0.004) by an average of 9.6 min.

Further adjustment for gestational age at birth, sociodemographic factors, comorbidities and parental history of IHD resulted in a moderately attenuated risk estimate that remained highly significant (fully adjusted HR for <−2 SD vs −1 to <1 SD, 1.54; 95% CI 1.15 to 2.07; p=0.004), and an inverse trend remained across the full range of fetal growth (fully adjusted HR per additional 1 SD, 0.93; 95% CI 0.87 to 0.99; p=0.04) ( table 1 , adjusted model 2).

Additionally, although TAS levels appeared higher in the LPS+NEB group compared to the LPS group, this difference did not reach statistical significance. Moreover, TAS levels showed a significant increase in the NEB group compared to the LPS group ( p = 0.004).

(B) A positive trend with urban land cover ( β = 0.008; p = 0.004).

Impact of pridopidine on global clinical progression (cUHDRS) In the mITT population off ADMs, pridopidine showed nominally significant benefits in maintaining cUHDRS scores compared with placebo, with the largest differences (Δ) at week 26 (Δ = 0.46, P = 0.004; placebo n = 112, pridopidine n = 95), week 39 (Δ = 0.45, P = 0.014; placebo n = 107, pridopidine n = 90) and week 52 (Δ = 0.41, P = 0.035; placebo n = 104, pridopidine n = 91) (Fig. 3a ).

Surprisingly, mice that received only a twice-greater dose (10 μCi) demonstrated greatly decreased tumor growth inhibition, and the tumor volume difference between mice receiving the 5 μCi versus the 10 μCi dose became extremely significant over the ensuing two weeks ( P <0.004).

There is a borderline difference in the pPDT ratio between the two groups (p = 0.066), but there is a highly significant difference in the pPTT ratio between these two groups (p = 0.004) with pPTT begin significantly reduced in those with CP compared to controls.

The standardized and adjusted size effect of PAH in the two-pollutant model was highly significant and about ten times stronger ( β = −0.20, p = 0.004) than that attributed to PM 2.5 ( β = −0.02, p = 0.757).

RCS results demonstrated a nonlinear dose-response relationship between OSA risk and FI levels, with an increasing trend (P = 0.004).

A similar dose-dependent gradient was evident in the tertile analysis, where the P for trend was highly significant for moderate/severe IDA ( P = .004) but not for mild IDA ( P = .164). 4.