Excerpts

During the period from 2014 to 2021, the number of hospitalized cases of CD had an increasing trend year by year ( r = 0.876, p = 0.004); meanwhile, there was no significant change in the number of UC inpatients ( r = −0.119, p = 0.780) ( Figure 1 ).

For comparison, only 10.3% of the VGLUT2 boutons that were in the vicinity of the cell showed eGFP and this difference is highly significant ( p = 0.004; Wilcoxon matched pairs).

Accordingly, highly significant effect was observed after short treatment (p<0.004).

Molecular assay As shown in Figure 7a , AOM induced colon cancer group showed highly significant increase (P=0.004) in level of TP 53 gene expression as compared to control group.

Primary and secondary care diagnostic intervals and stage of CRC For the combined cohort, we observed a significant trend for a concave, ∩-shaped association with increasing and subsequently decreasing odds of advanced CRC with longer primary care intervals ( P =0.004).

When combining the highly specific criteria size (cut-off value 10 mm), inhomogeneous signal intensity, and number of visible lymph nodes n ≥ 7, a highly significant association with nodal metastases (pN+, p = 0.004) was found.

However, when considering statistical associations with serological status, generalized lymphadenopathy showed a highly significant association ( P < 0.004) with seropositivity followed by cervical lymphadenopathy ( P < 0.032) ( Table 5 ). 4.

A significant trend for associations with WHZ were only observed for the maize and fish-based DPS in the multiple-adjusted model (0.03, 95% CI: 0.01, 0.06, p = 0.004).

Intriguingly, we identified a correlation between rs1800734 and DCLK3 expression in the healthy ( P =0.029, linear regression model) and tumour ( P =0.031, linear regression model) samples, and this association was highly significant in the MSS patients ( P =0.004, linear regression model) ( Fig. 2e ), indicating this locus may act as a distal enhancer and regulate DCLK3 .

The PCT improvement was highly significant in the aggregated analysis (p = .004).

Attention by gender to body attractiveness of the influencers was confirmed when it was verified that males placed faster attention (TFF = 0.33; p = 0.994), of longer duration (TFD = 3.99; p = 0.204), and with a higher number of fixations (FC = 7.33; p = 0.898), on the buttocks of the female influencer; the attention by females was partially significant with regard to the stimuli in which the male influencer showed his naked torso (E6-AOI3; TFF = 2.10, p = 0.004; TFD = 1.58, p = 0.001; FC = 3.59, p = 0.075), with the greatest differences being seen in E8-AOI 2 (TFD = 2.08, p =<0.001; FC = 5.73, p =<0.001).

Compared with WT microbiota, we found a highly significant overrepresentation of the genus Helicobacter ( P = 0.004, Bonferroni corrected), and a significant underrepresentation of the genus Prevotella ( P = 0.008, Bonferroni corrected) (Fig. 2 and Additional file 1 : Table S2).

This effect was highly significant (p = 0.004).

Highly significant reduction in HDRS (p = 0.004) and CGI-BP (p < 0.0001) from baseline to endpoint were also noted.

The interaction effect by gender approached significance (P for interaction = 0.053), revealing a stronger association among males (OR = 0.34, P = 0.004).

The association between NEE and StO2 remained highly significant ( p = 0.004).

We confirmed a decreasing trend in both decades, with a yearly average decrease of 6.4% (IRR=0.939, 95% CI 0.899–0.980; p=0.004) in the first decade, and of 6.2% (IRR=0.920, 95% CI 0.849–0.997; p=0.043) in the second decade.

The evaluation of the two different groups revealed that fetuses in the high HRV group showed a highly significant effect of the global rule (F(1,34) = 9.33, p = 0.004) while fetuses in the low HRV group showed no significant effect of the global rule (F(1,19.28) = 0.69, p = 0.417; Fig. 6 ).

There was a highly significant association between HER2 positivity and increased VMP1 mRNA levels in all cohorts: in cohort 2 p = 0.004 ( S4 Table ), in TCGA p = 0.003 ( S5 Table ), and in METABRIC p < 2.2x10 -16 ( S6 Table ).

The correlation between predicted and actual outcomes of the three validated questionnaires was moderate to strong and highly significant ( r = 0.464 − 0.733, p < 0.004) ( Table 4 ). 3.3.

In the other two conditions, we either fail to find evidence for a statistical difference across the two orders (shape-color: χ 2 = 1.96, p = 0.376) or the difference is marginally non-significant (size-nationality: χ 2 = 10.8, p = 0.004).

This difference was extremely significant ( P = 0.004 and P = 0.002, respectively).

Sire breed had a highly significant influence on SCS (overall F-test p = 0.004).

In the Cochran–Armitage test, an increasing trend was observed in the infection rate among close contacts ( P = 0.004).

coli and Eganviruses was highly significant in GVHD group (r = −0.570; p = 0.004).