Excerpts

In these 6 families, we found highly significant associations between SNVs in the Disks Large-associated Protein 1 (DLGAP1) gene and grip strength (lead SNV: β= -0.75kg ± 0.15, p-value= 4.3*10-6).

A Paired T-test showed a highly significant difference in time-to-complete retrofitting tasks between the proposed framework and CloudCompare, T(15) = 2.78, p = 4.35 × 10 − 6 .

One site has borderline significance in both the differential methylation analyses of SEL (−log10(p) = 5.36 and the differential methylation analyses of F2C (−log10(p) = 7.24).

Correlation Analysis There were highly significant positive correlations between antigliadin IgG antibodies and claudin-1 (r=0.554, p=4.39*10 −6 ), and between claudin-1 and i-FABP (r=0.687, p=1.38*10 −9 ).

Within the HoA+, Pf PR was a highly significant predictor of Pv PR Fy+ (p = 4.4x10 -6 ) up to 15% Pf PR, after which increases in Pf PR did not result in further predicted increases in Pv PR Fy+ ; in contrast, Pv PR Fy+ within the HoA+ was a significant linear predictor of Pf PR at all levels of endemicity.

This is exemplified by the highly significant difference in PPA activity in no-blink vs. blink trials (t(23) = 5.97; p = 4.4*10-6), listed below.

Finally, the KEGG database showed the “mitigation of Neutrophil extracellular trap pathways” as a highly significant ( P = 4.5 × 10 -6 ), suggesting that ASCs modulate the inflammatory cascade via neutrophil activity.

In the OS analysis, patients with higher ZW10 expression exhibited a significant trend toward reduced survival (n = 2976, HR = 1.71 [1.36-2.15], P = 4.6e-06), while lower ZW10 expression levels were associated with a modest improvement in survival.

In terms of species diversity, the Shannon indices were significantly higher in high-richness samples of the stipe (7.237–7.377) compared to the pileus (1.730–5.832) and the hymenophore (1.483–4.249), with extremely significant inter-part differences ( p = 4.7 × 10 −6 ).

Looking first at the conservative simple Reference Range Plus method, the analysis found a highly significant genotype effect as a high proportion of the rats were classified as low ( Table 2 ) (male dataset, p value = 4.75e-6 with a 43% change in classification and female dataset p value = 4.64e-3 with a 26% change in classification).

Finally, GWAS from the CARDIOGRAM Plus consortium 23 identified a moderately significant association between a SNP overlapping the TCONS00016111 transcript and human coronary artery disease (P=4.78E–6) ( Fig. 6g ).

Strikingly, 8 of the 9 known CHD genes in the module were within the hub, representing a highly significant enrichment ( P =4.787×10 −6 ).

The latter almost reached significance in the single-variant association test ( p = 4.79e–6, Table 3 ).

The lack of RCCGGY motifs within the regions surrounding σ E- regulating genes as well as vchM itself was highly significant (p-value ~4.8e-6).

For the different-strand overlaps, the majority of transitions (~60%) were due to 3' end change; the chi-square goodness-of-fit test for equal proportions of 5' and 3' changes is highly significant (χ 2 = 20.93, p-value = 4.8e-6).

Near significance of ss715615031, the significant marker for IRW, on Chr 13 ( P -value = 4.83 × 10 −6 ) and near significance of ss715585728, one of the significant markers for IRRS, on Chr 3 ( P -value = 1.11 × 10 −5 ) were observed for IPH.

We were not able to obtain similar predictive power using the DNAm age predictor proposed by Horvath, which has a highly significant but much weaker correlation with GA (r = 0.14, p = 4.89 × 10 −6 ; Additional file 1 : Figure S5).

The perfect association between copy number of the duplicated sequence and the fast/slow greying phenotype including both Connemara ponies from Sweden and Thoroughbreds from Japan is highly significant (Fisher’s exact test; P = 4.9 × 10 -6 ) (Fig. 3c , Supplementary Fig. 4a , Supplementary Table 2 ).

Group C significantly impacted average age while group B approached significance ( Figure 4C , p = 4.99 e−06, 0.0617).

Saturation of PSMA with a large excess of unlabeled compound causes a highly significant (p< 5 x 10 -6 ) reduction of binding of each labeled compound to cells, which demonstrates the saturable character of their binding ( Figure 3 ). 3.3.

The likelihood ratio test suggested a highly significant linkage disequilibrium between D6S446 and D6S1590 (p < 5 ×10 -6 ).

These correlations were still highly significant within the AM group (all 3 r ’s ≥ 0.55, all 3 P -values ≤ 5.0 × 10 −6 ).

The degree of independence and the number of operations A positive trend was observed ( r = 0.38, confidence interval 0.22 ÷ 0.52, df = 129) between the child’s dependence and the number of operations he or she had undergone ( p = 0.000005) (Fig. 2 ).

There was a highly significant difference between the PA and SD patients on this measure, t (18) = 6.87, p < .000005, one-tailed.

All comparisons were highly significant after Bonferroni correction ( P < 5 × 10 –6 , Wilcoxon signed-rank test).