The test for the overall effect is highly significant (Z = 411.50, P < 0.00001).
Excerpts
For all these follow-ups, meta-analyses showed highly significant results for the comparison between resin-based sealants and not treatment ( p < 0.00001) meaning that resin-based sealants efficiently prevented caries in children’s first permanent molars.
We found 449 genes common to both DEG sets of mouse Lhx2 cko and PRDM16 mutant organoids, which is highly significant based on hypergeometric statistics showing a representation factor 55.3 with a P -value < 0.00001 (see Methods) ( Supplementary Fig. 4D ).
These values were found to be statistically highly significant [ P < 0.00001; Table 4 ].
This correlation was statistically highly significant (P value < 0.00001).
After quality control and differential analysis, we identified 298 highly significant DMSs (p ≤ 1E-5).
The difference in the concordance of these 2 data sets was highly significant (p<0.00001).
Excluding Raman peak at 1,223 cm –1 ( p = 0.003), that emanated from the methine C-H deformation band and 1,771 cm –1 ( p = 0.07) from the ν (C = O) peak of proteins, the intensity scores of all the other Raman bands detected by spectral analysis exhibited a highly significant difference ( p < 0.00001) between the healthy and jaundice samples.
The statistical analysis revealed highly significant differences between the tested enterotoxin genes and virulence genes with p=0.00001.
The results indicate an extremely significant correlation of an NRF2 target being an upregulated gene (p-value < 0.00001 , Supplementary Table S5 ).
The groups did not differ significantly in April or May, but the difference was highly significant by June ( F 1,1068 =28.15, p <.00001, partial η 2 =.026).
Principal findings Our analysis revealed that Mavacamten significantly reduced LVOT gradients across various clinical scenarios, with a pooled MD of −38.28 mmHg for post-exercise gradients and −59.02 mmHg for post-Valsalva gradients, both highly significant ( P < 0.00001).
A sensitivity analysis for hematocrit revealed a highly significant increase (MD = 2.15; 95% CI = 1.86–2.44; p < 0.00001).
The strikingly different microsatellite distribution in isolates carrying a resistant or a sensitive haplotype was highly significant (chi-square test P < 0.00001).
The ICI and WI showed a strong and highly significant correlation (r = 0.53141, p < 0.00001).
Hence, we detected a highly significant ( P < 0.00001, Fisher's exact test) correlation between trees homozygous for the acro ‐SNP and the early cone‐setting phenotype.
Although Pd-MOF produced a highly significant downregulation of VEGFR2 gene expression in A549 cells compared with the untreated control ( p < 0.00001; Fig. 7 D), its inhibitory potency remained considerably weaker than that of the reference drug, sorafenib.
This was highly significant with a P = 0.00001.
Indeed, four, highly significant (pairwise homoplasy index test, P < 0.00001) signals of recombination have been revealed at coordinates closely corresponding to the divergent regions.
After overlapping the pQTL variants with the nominally significant ( P <1 × 10 -5 ) association signals of the GWAS Catalog, they identified that the CD33 protein-related SNP rs1878047 was also associated with BMI.
Between the Non-Gly and the Gly subtypes, we identified 763 highly significant Differentially Expressed (DE) genes (Adj. p < 1E-05), 296 of which over-expressed in Gly subtype and 466 over-expressed in the Non-Gly tumors ( Figure 2A and Supplementary Table 3 ).
The F-ratio comparing the variances across time was highly significant (F 479,479 = 14.5144, P < 0.00001).
In our study, the 2R/3R genotype was the most prevalent among Jordanian women, representing 69% of the control group and 50% of breast cancer patients—a difference that was highly significant ( p < 0.00001).
The excess of transition paths is highly significant by a binomial test ( P < 10 − 5 ; here and below, we do not distinguish values of P below 10 − 5 ).
The results revealed a highly significant genetic structure in B. kashmirensis populations ( p < 0.00001) (Table 4 ).