Excerpts

Correlation analysis across six independent bulk transcriptomic cohorts (TCGA-PAAD, ICGC-PAAD-CAseq, GSE85916 , GSE79668 , GSE71729 , and EMTAB6134) demonstrated a highly significant positive association between THBS2+ CAF signature scores and T-cell exclusion scores (all p < 1 × 10−5), indicating that tumors with high THBS2+ CAF infiltration exhibit restricted T cell access to tumor nests ( Fig. 4 B).

The overall differences between infected and non-infected hosts according to seasons were all highly significant for both parasitic species (p≤ 0.00001).

Correlation of fQRS distribution on surface ECG and anatomical CAE location We found a highly significant correlation between increase in the number of ECG territories affected by fQRS and multivessel affection by CAE ( P = 0.00001).

The identification of moderately significant (10 −2 >p>10 −5 ) SNPs offers a novel method for detecting the “missing heritability” of hypertension.

These values were found to be statistically highly significant [ P < 0.00001; Table 4 ].

In contrast, five of the 13 SCC control cases exhibited P63 positivity, demonstrating a highly significant association (p < 0.00001).

A meta-analysis of 2921 participants with type 2 diabetes treated with an IL-1-blocking therapy showed a highly significant reduction in HbA 1c ( p <0.00001 [ 88 ]).

This difference, favoring the untreated patients, is highly significant ( P < 0.00001). 19 Hematomas are not inconsequential. 11 Blood transfusions should rarely be needed for cosmetic surgery patients.

The advantage of KRR and KMER over RR is highly significant ( p = 1 × 10 −5 ; permutation testing), but the advantage of KMER over KRR is not significant ( p = 0.093).

For all these follow-ups, meta-analyses showed highly significant results for the comparison between resin-based sealants and not treatment ( p < 0.00001) meaning that resin-based sealants efficiently prevented caries in children’s first permanent molars.

Pairwise F ST values with outlier SNPs were all highly significant ( p < 0.00001) and were highest for comparisons involving the conventional plot ( F ST = 0.071 for conventional versus semi-conventional; F ST = 0.070 for conventional versus semi-organic; F ST = 0.049 for semi-conventional versus semi-organic).

In contrast, a highly significant increase in midbody-flanking Sept2 ( p -value < 0.00001) and a corresponding decrease in Sept2 at the central midbody ( p -value < 0.00001) were detected relative to the Jurkat CypA+/+ cells ( Figure 1 E).

So, even at ages 70–79, a 2SD higher apoB/apoA 1 ratio was associated with a highly significant ( P < 0.00001) relative risk of 3.13.

As in the previous analysis the variable synchrony was highly significant [F(1,14) = 44.76, p = .00001], with stronger agreement after synchronous (7.10) than asynchronous training (2.99).

However, the effect estimates from the four studies reporting HRs did not reach statistical significance (HR: 1.12, 95% CI: 0.96–1.31; I 2 = 100%, p < 0.00001) ( Figure 2 ).

There was a highly significant pre/post decrease in the in the emotional exhaustion (p < 0.00001) and depersonalization scores (p < 0.001), with highly significant increase in the personal accomplishment (p < 0.00001) scores.

The test for the overall effect is highly significant (Z = 411.50, P < 0.00001).

This was also highly significant ( p <0.00001).

In fact, both correlations are highly significant (p < 0.00001 for each in Fig 2B ).

Also, the presence of two or more risk factors resulted in a highly significant elevation of risk for severe vomiting (OR 15.97; 5.12–49.87; p < 0.00001) (The second table in Section 2.7 ).

The amplitude of the N1 component showed a highly significant color adaptation effect [ F (1, 13) = 71.6, P < 0.00001].

The results of the bootstrap approach demonstrate that the ability of the top genes to correctly order the lROIs is highly significant (p < .00001).

The test for overall effect was highly significant (Z = 7.99, p < 0.00001), confirming the beneficial impact of the interventions on PFS.

This is a highly significant increase over previous levels ( t = 14.79, df = 94, P<10 −5 ).

This analysis focused on the remaining three high-quality RCTs (n = 217), revealing strengthened evidence for topical CCBs: the odds ratio for unhealed fissures increased to 3.12 (95% CI = 1.78–5.47, p < 0.0001), while the previously nonsignificant difference in side effects became highly significant (OR = 13.16, 95% CI = 5.05–34.3, p < 0.00001) with resolved heterogeneity (I 2 = 0%).