The results revealed that on average the wound healing time of the hydrogel dressings group was shortened by 5.04 days as compared with the control group and that statistically this difference was highly significant (MD = −5.04, 95% CI: −5.81 to −4.26, P < 0.00001).
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This difference was highly significant ( p < 0.00001, Chi-square test).
Two of these loci, 3p24.1 and 16q12.1, are nominally significant ( P < 1 × 10 −5 ) in our GWAS meta-analysis, but the remaining three loci (3q29, 17q25.3 and a distinct region at 22q13.1) do not reach nominal significance.
Two of these SNPs, rs7948623, rs11230664, are also genome-wide significant GWAS SNPs for pigmentation variation in Africans, while the third, rs3741265, is marginally significant ( p < 10 −5 , Fig. 5 ).
The depicted IBD segment in Figure 3 has a highly significant IBD score ( P -value < 1E-5).
Also, the presence of two or more risk factors resulted in a highly significant elevation of risk for severe vomiting (OR 15.97; 5.12–49.87; p < 0.00001) (The second table in Section 2.7 ).
Results Nadi Shodhana Pranayama showed a significant decrease in ART (p = 0.01) and Bhramari Pranayama showed a highly significant decrease in ART (p < 0.00001).
The differences were found to be highly significant ( t -test, p < 0.00001).
The Fst values were relatively high and reached highly significant levels (p < 10 −5 ) between populations from Tak (all collection periods) and Yala-Narathiwat (21.75%), and between Ubon Ratchathani and Yala-Narathiwat (19.44%), implying genetic differentiation or limited gene flow between these endemic areas.
Potential sequences with replaced 23 bp regions were then scored by FIMO ( 48 ) for matches to motifs identified by MEME and two sequences with highly significant P -values ( P < 10 −5 ) were retained for experimental testing.
Additional SNPs approaching significance (p<1×10 −5 ) cluster within a 70 kb region of chromosome 10q23.31 that spans RPL7P34 and a gene called renalase ( RNLS ; MIM: 609360) ( figure 1B ).
This was found to be statistically highly significant ( P < 0.00001).
The similarity in prognostic group assignment was highly significant ( p <10 −5 by Chi-square test).
Besides, we use the Pearson Chi-Square test to evaluate the distribution of FIGO stages I, II, III, IV among expansile and infiltrative tumors, and found there was a highly significant association between tumor type and FIGO staging (Pearson chi2(3) = 110.9206, p <0.00001) Figure 4D . 3.3.4 Publication bias Publication bias was investigated by Begg’s funnel plots.
The chi-squared goodness of fit test showed that 46.5% (1115) of the markers significantly differed from the expected 1:1 Francis to Rondo allele ratio at p < 0.05 and 7.6% (182) of the markers had highly significant segregation distortion at p < 1e−05.
Between the Non-Gly and the Gly subtypes, we identified 763 highly significant Differentially Expressed (DE) genes (Adj. p < 1E-05), 296 of which over-expressed in Gly subtype and 466 over-expressed in the Non-Gly tumors ( Figure 2A and Supplementary Table 3 ).
However, when considering the combination of adding CBCL+BPRS, this yielded a strong increase in prediction accuracy that was highly significant compared to considering only the SIPS (MSE of SIPS=0.74±0.62, MSE of SIPS+BPRS+CBCL=0.716±0.59, p<0.00001) or separately adding BPRS (p<0.00001), or CBCL (p<0.00001) (see Figure 3C ).
Seven other RSA traits were modified in both IL99 and Ruta reflecting the common response to LN (Figure 3a–g ) but showed a highly significant change in IL99 ( p < 0.00001) and lower significance in Ruta, including maximum number of roots*, number of root tips, total root length*, network area*, volume, surface area, and holes* (i.e., traits marked with* were advantageous in IL99 over Ruta under the LN treatment (Figure 3a–g ).
The interaction effects on breast cancer risk of these five TF pairs were all highly significant ( P < 1 × 10 −5 ; Supplementary Data 2 ).
Additionally, infertility showed a clear trend of increasing prevalence with rising BMI, reaching 38.5% in patients with BMI ≥ 30 kg/m 2 ( p = 0.00001) ( Table 3 ).
All differences were statistically highly significant ( p < .00001).
The advantage of KRR and KMER over RR is highly significant ( p = 1 × 10 −5 ; permutation testing), but the advantage of KMER over KRR is not significant ( p = 0.093).
The results indicate a nonsignificant trend toward left-sided tinnitus ( P = .07) and a highly significant association between ear-piece location and tinnitus location ( P < .00001).
A meta-analysis of 2921 participants with type 2 diabetes treated with an IL-1-blocking therapy showed a highly significant reduction in HbA 1c ( p <0.00001 [ 88 ]).
Three homogenous studies reporting procalcitonin documented a highly significant value ( p < 0.00001) with a I 2 value of 57% and odd ratio of 5.77 (95%CI: 3.35, 9.95) beyond the cut off value of 0.1 ng/mL [ Figure 6b ].[ 14 , 15 , 20 ] Investigation of heterogeneity Heterogeneity was found in all the comparisons with I 2 value ranging from 56% to 99% [ Table 3 ].