Excerpts

3.2 Response to ETI therapy initiation Effects of ETI therapy assessed with averaged CFAbd-day2day © responses revealed a highly significant decrease in the median total score ( p = 0.00001).

The speed and ambiguity regression coefficients captured by the model were highly significant for all groups ( p < 10–5), and the between group differences in both speed and ambiguity regression coefficients were also highly significant ( p < 10–5).

5 ) in test 1 and 61% in Test 2; “Treatment*Pre/Post” was negative and highly significant ( P < 10 -5 ; Additional file 6 : Table S2; Additional file 7 : Table S3).

Overall, supporting the validity of the estimated model parameters, a simple correlation analysis between observed confidence changes and estimated changes computed with the mathematical model equations, yielded a highly significant correlation ( n =20, Pearson's r =0.748, P <10 −5 , Supplementary Fig. 7c ).

Highly significant inter-study heterogeneity was noted (I 2 = 85%; χ2 p= 0.00001).

A new repeated measures ANOVA excluding the local recombination estimates for SNPs with MAF < 0.1 was applied and the differences in recombination rates between the groups remained highly significant ( P < 0.00001).

In contrast, less blood loss, shorter hospitalization time and less operative transfusion rate in laparoscopic liver resection were all highly significant (P<0.00001–0.0008).

The outcomes of the study outlined a statistically highly significant negative correlation between the level of education and drug use (Pearson test, R (38) = −0.9282; p < 0.00001).

A highly significant ( p ≤ 0.00001) reduction of E‐cadherin expression was observed in the order of HPV16+ < HPV18+ < HPV16+/18+ in both cell models.

Chlorophyta and Toxoplasma seem to have a significant positive influence on each other ( P < .01), whereas Dictyostelium and Plasmodium seem to have a highly significant positive influence on each other ( P < 10 −5 ).

During the Conditioning phase, highly significant (p<0.00001) main group and training day effects were observed and those were sustained over the entire period of Conditioning.

Not surprisingly, the effect of motion direction was highly significant (t(17)=21, p<10 -5 ).

Despite this high level of variability, the overall effect remained highly significant (Z = 5.15, p < 0.00001), indicating the consistent benefit of the combined treatment in accelerating jaundice clearance in neonates ( Figure 5 ). 3.6.3.

Highly significant difference was also observed in staining intensities between low malignant cases and highly malignant cases (χ 2 test, P<0.00001).

Cross-population transferability of loci Of the nominally significant ( p < 1 × 10 −5 ) loci in the short and long sleep duration analyses in the AFR GWAS, none reached even a nominal significance threshold of p < 0.05 in the EUR analysis, and none demonstrate a lower p-value in the cross-population analysis.

The differences were highly significant for both Fusobacterium and Porphyromonas (FDR-adjusted p -value < 0.00001, Fisher Exact test).

Among transcript and protein levels, genes that varied most across strains were involved in aerobic respiration and the electron transport chain, with highly significant gene ontology enrichment ( P < 10 −5 ) for cellular respiration, ATP synthesis coupled proton transport, and mitochondrial respiratory chain complexes (Supplemental Table 4).

The fact that the result remains highly significant ( p < 0.00001) with a narrow confidence interval after removing the outliers strengthens the conclusion that TCM external therapy is efficacious, and the initial overall estimate was not merely an artifact of heterogeneous studies.

In DHLF-COPD the Mann-Whitney U test showed a highly significant difference in distributions (U = 41246, p = 1.01 × 10 −5 ) and Mood’s Median Test confirmed a significant difference in medians (χ 2 = 15.82, p = 7 × 10 −5 ) comparing control and treatment group while in NHLF no significant correlation could be detected (Fig. 6 A).

The correlation between the ranking of amino acids of Figure 4 A and the one in Figure 5 E was highly significant (ρ = 0.81; p = 1.03 × 10 −5 ), despite the limited number of epitopes with available X-ray structures used to estimate amino acid frequencies in Figure 5 E.

Here, an equivalent time point comparison at 15 min revealed that CBD invoked a highly significant negative shift in Va from a baseline value in control recordings of Kv7.2 wt + Kv7.3 of −29.8 ± 1.25 mV to −35.6 ± 1.36 mV (n = 8; p = 1.06 × 10 −5 ) in CBD ( Figure 5 A).

We mapped the regional presentation score of the most highly represented protein in the neuroblastoma ligandome, NPY (29 MHC Class I peptides detected in 16 neuroblastomas), finding a highly significant concordance between the empirically detected peptides and those regions of the protein expected to be highly presented ( Figure 3E ; p = 0.000011), and find no peptides in the ligandome derived from the signal peptide region (aa 1–28) which is cleaved from the full-length pro-NPY protein.

The OPLS-DA model showed a good fit (R 2 = 0.65), predictivity (Q 2 = 0.55) and a highly significant CV-ANOVA ( p value = 1.1E −5 ).

Indeed, when we compared the South African and Canarian goats with the remaining populations, estimated F ST coefficients were moderate (F ST = 0.06–0.14) but highly significant ( P < 1.10 −5 ).

Additionally, the Arg460Gly variant independently showed a moderately significant protective association with the heavy smoker phenotype (OR = 0.56; CI = 0.43–0.72; P = 1.1 × 10 −5 ).