Statistical analysis Analysis of variance showed highly significant differences among ranks ( p <0.0001), in terms of the number of genes coding for TFs, as depicted in Additional file 10 .
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The correlation between HER4 H-Score and HER4 RT-qPCR was highly significant, with a correlation coefficient of r2= 0.85 (p<0.0001; CI: 0.80-0.94) for the neoadjuvant cohort (Figure 2A ) and r2= 0.75 (p<0.0001; CI: 0.44-0.84) for the metastatic cohort (Figure 2B ).
There was a highly significant trend in risk ( P =<0.0001).
Although the individual GARCH term was nominally non-significant, there was a highly significant (P=0.0001) test of joint significance of the ARCH and GARCH parameters.
For sub-lineage K-IIc, both neutrality tests were strongly negative and highly significant (Tajima’s D = −0.0850, p < 0.0001; Fu’s Fs = −27.7220, p < 0.0001), jointly pointing to a pronounced excess of rare haplotypes consistent with a recent and rapid population expansion.
We further monitored Gluc activity for up to 148 min achieving a highly significant 10 times greater signal for the SARS-CoV-2-pseudovirus versus the control pseudovirus ( P < 0.0001) ( Figure 3 (a), right).
These values were all highly significant (p < 0.0001).
After 120 days of therapy, pitting edema score increased significantly in racemic amlodipine group compared to (S)-amlodipine ( p = 0.038) and increment of score was highly significant ( p < 0.0001) with amlodipine compared with baseline value (Table 2 ).
The coefficients for an unassigned genus of Bacteriaceae and for the genera Blautia , Dorea , Clostridium , Fusobacterium , Oscillospira , Phascolarctobacterium , Slackia and Streptococcus were highly significant (P<0.0001, S6 Table ).
While the correlation between the parameter estimates was highly significant, it was very weak due to the disparity in effect magnitude (R 2 = 0.194; p < 0.0001).
Highly significant seroprevalence increases (p<0.0001) from children to younger adults (15–34 years) (but not from younger to older adults >34 years) were seen for mucosal α (HPV 16), γ (HPV 4, 65) and both μ PV (HPV 1, 63).
The correlation between the 3 different assays was highly significant ( p < 0.0001).
Other metabolic changes included a highly significant increase in free MyI, easily measured from its signal at 4.05 ppm: 2.61 ± 0.28 vs. 1 ± 0.55, p < 0.0001, n = 7 vs. n = 5, SUM1315-BRCA1 vs.
This decrease was highly significant [Bl6: F (4.2, 78.9) = 6.82, p < 0.0001; C3H: F (3.9, 137) = 13.0, p < 0.0001].
All correlations coefficients shown in Additional file 1 : Table S1, Additional file 2 : Table S2 and Additional file 3 : Table S3 were highly significant ( p < 0.0001).
Additionally, the VLP18-Fab antibody demonstrated a highly significant and dose-dependent neutralizing activity against HPV18 pseudoviruses (P < 0.0001).Moreover,following identification, the structure of the antibody-antigen binding complex was simulated using BIOVIA Discovery Studio, which included the identification of potential binding sites.
Their respective values of areas under the curves (AUC) of ROC curves were 0.76, 0.68 and 0.91 respectively, of which all exhibited highly significant differences (p<0.0001) compared with the control subjects.
The differences were statistically highly significant ( χ 2 = 1689.11, P < 0.0001).
Expression of PR and ER demonstrated highly significant correlation (Spearman's ρ = 0.60, P < 0.0001).
This distribution turned out to be statistically highly significant (p<0.0001) and has many points in common with survival curves defining the Gompertz law, which describes the lifetime long pattern of acceleration and deceleration of mortality [ 50 , 51 ].
An unpaired t test showed that this difference was highly significant ( p < 0.0001).
Across the three-day measurement period, foliar application of SiNPs elicited a highly significant increase in stomatal conductance ( p < 0.0001) relative to controls under ambient UV-B ( Figure 2 a), with values of 326 ± 2.7 to 596 ± 1.5 mmol m −2 s −1 in treated leaves versus 211 ± 2.1 to 414 ± 4.4 m −2 s −1 in controls.
In contrast, the mean urinary melatonin level was significantly lower in stroke cases (7.18 ± 1.91 ng/mL) than in controls (14.26 ± 1.98 ng/mL), and this difference was very highly significant (t = 19.93, p < 0.0001).
Participants who rated their familiarity as “Poor” were significantly more likely to be classified as engaging in “Poor Practice” concerning off-label drug use, as indicated by a highly significant residual ( P < .0001).
galegae , the LRT was highly significant (P < 0.0001), and the parameter estimates for N. galegae nifQ indicated an increase in the relative rate of non-synonymous substitution by a factor of 3.