Excerpts

In contrast, polygenic risk scores (PRS) aggregating effects of minor alleles of independent SNPs that were adversely or beneficially associated with disability showed highly significant associations in meta-analysis, p=3.13×10-45 and p=5.60×10-23, respectively, and were replicated in each study.

In contrast, polygenic risk scores (PRS) aggregating effects of minor alleles of independent SNPs that were adversely or beneficially associated with disability showed highly significant associations in meta-analysis, p=3.13×10-45 and p=5.60×10-23, respectively, and were replicated in each study.

The paired change was highly significant (McNemar’s χ 2 (1) = 198.89, p < 3.65 × 10 −45 ) ( Figure 4 ).

MMP14 exhibited a marked increase in expression in tumor tissues, with a highly significant difference between normal and cancer groups ( p = 4.9 × 10 −45 ).

Among 11 prototypical sarcomere genes, 10 displayed highly significant isoform shifts (p = 5.23 × 10 −45 –2.89 × 10 −200 ).

When looking at the genes that overlapped between these two comparisons, we found 99 overlapping up-regulated genes and 84 overlapping down-regulated genes, which represented a highly significant overlap between comparisons ( Fig. 4 A ; P = 6.32 × 10 −45 ).

A chi‐square test confirmed that this enrichment was highly significant ( p = 1.1357 × 10 −44 ), underscoring the prominent role of DNA transposons in gene regulation.

That the three sets of enriched positions contained an overlap of 106 sites was highly significant with a hypergeometric P < 1.47 × 10 −44 .

Another highly significant but non-genic SNP coincides with a selection candidate region (e.g., Figure 3C ) covering the KIT and KDR (P = 2.46e-44) loci.

Compared with the control group, the differences in muscular layer thickness, the length of pyloric canal and the diameter of pylorus were highly significant (P = 7.44E-44, 3.01E-73, 5.77E-29), and the thickness of mucosal layer remained significant (P = 6.34E-18) (Table 2 ).

A highly significant overall association between PRS and COVID-19 infection was shown for the White ethnic group ( p = 8.69 × 10 –44 , < 0.0001).

Notably, there was a highly significant overlap of senescence-associated metabolic changes in MSCs and iMSCs: 67 metabolites were consistently downregulated (hypergeometric distribution: p < 10 −43 ) and 9 metabolites were upregulated at later passages in both cell types (p < 10 −10 ; Figure 3 C).

Subsequent memory effects in selective neurons Due to the preceding screening procedure, we found highly significant fractions of neurons responding selectively to one or more items in all recorded brain regions (all P < 10 –43 , binomial test, one-sided with n = total number of neurons per region, k = number of responsive neurons per region, P = 0.001, corresponding to the alpha level of our response criterion, refer to “item responses”, Fig. 2 , Fig.

A total of 18 SDRs were identified across the genetic maps, primarily located on LG1–LG4, LG6, and LG8, with LG8 and LG3 containing 5 and 4 SDRs respectively, Strong collinearity between the genetic map and physical assembly was confirmed by highly significant Pearson correlations (R = −0.84 to 0.83; P = 10 −43 to 10 −217 ) for marker positions across all nine chromosomes ( Table S9 ; Fig.

26 , 28 - 31 A subsequent meta-analysis, which included 5,159 patients with AIS and 17,840 controls, reported a highly significant association with this SNP, with a P = 1.22 × 10 -43 for both men and women, and an even stronger P = 2.94 × 10 -48 for women only. 32 The present study established a significant association between the LBX1 polymorphism rs11190870 and AIS susceptibility ( P < .001), consistent with prior research conducted across diverse populations, particularly in East Asian cohorts.

The possible correlation between the allele frequency of SNP1 and wool production was extremely significant ( P = 2.50E-43) ( Fig. 3 d ).

To compare our findings to a genetic variant with known association with neurodegenerative diseases and aging, we made similar analysis with the frequencies of APOE ε4 allele, which showed a highly significant decrease with age ( p = 3 × 10 −43 ).

This finding was highly significant (p = 4.5×10 −43 ).

The predicted interactions between known and unknown motifs as well as between unknown motifs are likely to be novel interactions, in particular those with strong and highly significant interactions, such as the interactions for predicting the H3K27ac mark, between GLI2 and Temra 146 (γ = 2.137, p = 4.95e-43), between TEAD3 and Temra 54 (γ = 1.97, p = 4.43e-50), and between Temra 141 and Temra 146 (γ = 1.99, p = 4.41e-43), etc.

Using various carbohydrate-deficient transferrin indices, and adjusting for alcohol intake, a recent GWAS isolated the highly significant independent effects of variants in the transferrin ( TF , P =5.5 × 10 −43 ), and phosphoglucomutase 1 ( PGM1 , P =2 × 10 −9 ) genes on carbohydrate-deficient transferrin. 126 Neuroimaging phenotypes Neuroimaging outcomes are promising new endophenotypes for addiction.

When epigenetic age estimates incorporated additional information pertaining to blood cell composition, the resulting time-to-death predictions were highly significant ( p = 7.5 × 10 −43 ).

The top TB network was highly significant (p = 10 −42 ) and included 20 focus genes implicated in susceptibility to Mycobacteria tuberculosis infection in a 35 gene network ( Table 1 , Fig 4 ).

The concordance between SomaModules and the optimal WGCNA clustering is highly significant (Fisher’s exact test p -value = 10 –42 ).

The difference between the observed T:B conjugate rate, and that predicted to arise by chance, was highly significant at up to P = 10 -42 .

Several additional C2H2 zinc finger protein binding sites were discovered with borderline significance ( P = 10 –42 ) for transcription factor proteins ZKSCAN1, ZNF467, and ZNF165.