Excerpts

The concordance between SomaModules and the optimal WGCNA clustering is highly significant (Fisher’s exact test p -value = 10 –42 ).

Several additional C2H2 zinc finger protein binding sites were discovered with borderline significance ( P = 10 –42 ) for transcription factor proteins ZKSCAN1, ZNF467, and ZNF165.

The top TB network was highly significant (p = 10 −42 ) and included 20 focus genes implicated in susceptibility to Mycobacteria tuberculosis infection in a 35 gene network ( Table 1 , Fig 4 ).

Although this overlap is highly significant ( P < 1.66e −42 ) it shows that even within the same species larger differences in genes detected to be bound by FoxP3 can be expected either due to the experimental design like cell lines or stimulation or due to genetic and biologic variance.

Segregation analysis gave a highly significant association between the C allele and disease (p = 1.8×10 −42 ).

After exclusion of Y chromosome genes, we observed a highly significant enrichment of differentially expressed genes on the X chromosome over the autosomes ( P = 1.8 × 10 –42 ; Figure 1B and Supplemental Table 2 ).

We found a highly significant correlation between both measurements in plasma samples, as shown in Fig. 1 a ( p = 2.6 × 10 −42 , r 2 = 0.902).

This difference was highly significant (Kruskal–Wallis χ2=185.15, P =3.64×10−42; Wilcoxon BH-adjusted P =3.66×10−42) ( Fig. 4b ).

4C , NMI and DRAM1 show a highly significant correlative expression with correlation coefficient (CC) of 0.71 and p < 3.7e-042.

Furthermore, there was a weak but highly significant negative correlation between the number of paralogs for a gene and its d N /d S ratio compared with orthologs (Spearman’s rank: r s = −0.131, P = 4.33 × 10 −42 ), suggesting that genes that are retained as paralogs tend to be under stronger purifying selection.

There is also a mild but highly significant correlation between the total number of targets involved in a combination and percentile of cell lines in which it is synergistic (Spearman’s ρ = 0.21, P = 6.25 × 10 −42 ), (Fig. 6A ).

The neighboring gene Pearson correlations were also found to be highly significant ( C. dubliniensis/C. albicans Pearson correlation = 0.218, p = 6.4 × 10 -42 ; C. tropicalis/C. dubliniensis Pearson correlation = 0.103, p = 9.8 × 10 -10 ).

There were highly significant main effects for emotion (F (2,155) = 171.744, p = 7.4 × 10 −42 , η p 2 = 0.708), agency (F (1,71) = 630.212, p = 4.9 × 10 −37 , η p 2 = 0.899) and intentionality (F (1,71) = 11.799, p = 0.001, η p 2 = 0.143), regardless of serotonergic status, which supports task validity and suggests individuals were attuned to the social context of the scenarios.

Here, using genome sequences from 11,670 women, we observed a highly significant association between a stress-related disease, major depression, and the amount of mtDNA (p = 9.00 × 10 −42 , odds ratio 1.33 [95% confidence interval [CI] = 1.29–1.37]) and telomere length (p = 2.84 × 10 −14 , odds ratio 0.85 [95% CI = 0.81–0.89]).

A non-parametric test revealed that the difference was highly significant (Mann-Whitney, p = 9.2 × 10 −42 ).

IPA identified a highly significant network ( p < 10 −41 ) containing 20 of the 64 (31%) input genes and 15 bridging genes ( Figure 2 ).

A t-test comparison at TSS for the random sample and the origin peaks demonstrated a highly significant difference (p<10 −41 , Fig.

The water-sensitive Predictive model ( P w ) was the winning model, outperforming the second best model, the water-sensitive Reactive model ( R w ), by a highly significant 95 log likelihood units ( χ 2 (2) = 190, p < 10 −41 ).

This result is highly significant (p=10 –41 , exact ranks test, MATLAB signrank ) and holds for all tested pitch classes in the pair ([0,3,6,9], Figure 4D ).

Chi-square tests yielded the most highly significant results for terpenoids ( p = 1.2 × 10 −41 ), amino acids and derivatives ( p = 1.6 × 10 −35 ), flavonoids ( p = 3.1 × 10 −33 ), lipids ( p = 4.8 × 10 −15 ), flavonols ( p = 1.8 × 10 −12 ), phenolic acids ( p = 2.6 × 10 −12 ), and flavones ( p = 1.1 × 10 −11 ). 3.2.

This difference is statistically highly significant (p = 1.2 10 -41 ; Chi-square test with 1 degree of freedom).

The results of this hypergeometric distribution analysis verified a highly significant overlap of 39 ( P = 1.46e−41).

1 , 5 ) revealed a highly significant difference across all four groups of neurons (control SWA, lesioned SWA, control activated, lesioned activated; Kruskal–Wallis ANOVA, χ 2 = 211, p = 1.60e-41).

Although Aβ and tau oligomer levels showed a highly significant correlation (Spearman r = .541, p = 2.7 × 10 −41 ), no increase of tau oligomer levels regarding the disease stage was observed (Figure 1B ).

cerevisiae proteasome genes, the enrichment of genes containing the known Rpn4p binding site was highly significant (GGTGGCAA; p < 6 × 10 –41 ).