Excerpts

When comparing allelic frequencies between HIV-controllers and the PRIMO seroconverters, four SNPs located within the 6p21 (rs2395029, rs13199524, rs12198173 and rs3093662, are in bold in Table 1 ), showed highly significant differences (p<10 −4 ) that correspond to a striking enrichment in HIV-controllers for protective allelic variants associated with HIV-RNA levels.

Each WHtR cutoff was a highly significant predictor ( P < 0.0001) with the inclusion of constructs for race, smoking, age, and sex.

The correlation between anti-RBD and anti-Trimeric S IgG with NAb titers was highly significant ( p < 0.0001) at each time point, being spearman r slightly variable over time ( Table 1 ).

Finally, all species showed a trend towards lower FFFs at night compared with during the day, irrespective of stimulus intensity ( p < 0.0001 for day versus night for bright stimulus and day versus night for dim stimulus for all species; electronic supplementary material, table S3) (c) .

Results: The difference in scores at all the 3 stations before and after the intervention and also global scores before and after the intervention was statistically highly significant ( P = 0.0001).

The primary endpoint was highly significant with an absolute EF improvement of 18.3% in the catheter ablation arm compared to 4.4% in the medical rate control arm ( P < 0.0001).

However, there was a highly significant interaction between temperature and drought strategy ( F 1,124 = 41.77, P ≤ 0.0001), indicating that these groups of species responded to the experimental heat treatments differently.

All variables but sex ( p = 0.814), upper quadrant periodontal assessment ( p = 0.513), and lower quadrant periodontal assessment ( p = 0.285) showed highly significant differences between the high-risk and low-risk clusters ( p < 0.0001).

Correlation of these two cytokines regarding the whole study group (n = 48) was highly significant (p < 0.0001, Spearmans rank correlation) upon stimulation with Penicillium chrysogenum (r s = 0.82) and Aspergillus fumigatus (r s = 0.80) and after stimulation with 10 pg/mL endotoxin (r s = 0.55).

The variance of repeated measurements in all models is statistically highly significant (Wald Z > 4.4, p < .0001), indicating that the variation resulting from multiple measurements of the same city using different methods and indicators constitutes the primary component that the model needs to explain.

The same group 5 from Portland, Oregon, has also utilized a simulation model involving video set up and put away times to demonstrate a highly significant ( P =0.0001) difference in operating room efficiency in a dedicated minimally invasive surgery suite versus a traditional OR.

The resulting Spearman's correlation coefficient, r, was 0.65 (95% confidence interval 0.45–0.79), which was highly significant (P<0.0001).

These three trend indicators were still highly significant ( p < .0001) when added jointly to the existing model using the following transformations: X 3 + X 3 *log(X) for the absolute change in the risk score from the previous day; X 0.5 + X 0.5 *log(X) for the absolute change in the risk score from the start of the trend; and X -2 + X -2 *log(X) for the number of consecutive days with a trend in the risk score (we first shifted all original values up by the minimum observed value to ensure the values were greater than zero).

Patient by patient calculation of the value of difference of the angle of IR between left and right hip revealed extremely significant difference (p < 0.0001, Wilcoxon matched-pairs signed-ranks test); a similar significant asymmetry between the left and right hip was found for the ER (p < 0.0001).

The results confirmed a highly significant monotonic decrease in the self-generated preparatory advantage from the first to the final move ( p < 0.0001; cluster mass = −1,779.65; −1,000 to +495 ms), indicating that preparatory activity became progressively less self-specific as the sequence unfolded ( Fig. 3 , right panel).

The results indicate that Group (ASD and the two TD groups) and Task (with and without objects) as main factors, are highly significant: (Group: F [2,75] 72,55 p<.0001; Task F [1,75] 220,52 p<.0001).

At 1 mm apical to TP, group differences were highly significant ( p < 0.0001), with no time ( p = 0.93) or interaction effects ( p = 0.70).

Pairwise comparison between groups at each time revealed that all the test compounds induced a highly significant ( p < 0.0001) reduction in BGL comparable with the standard drug rosiglitazone.

Remaining 16 IA-predicting candidate loci (6 intergenic, 8 intronic, and 2 synonymous SNPs; log10BF > 6.1 and p < 5 × 10 –8 ) were not accompanied by any neighbor promotor or functional variations such as UTR, missense, and nonsense SNPs that showed both moderate to strong LD (0.5 < r 2 < 1) and marginally significant associations ( p < 0.0001, data not shown).

These values were all highly significant (p < 0.0001).

This difference was highly significant (one-way ANOVA: F = 98.53, p < 0.0001), and a post hoc Dunnett’s test confirmed significant differences between our SYNZIP2-GFP control and SpyTagged GFP (SYNZIP2-GFP vs GFP-SpyTag: t = 6.925, p < 0.0001; SYNZIP2-GFP vs SpyTag-GFP: t = 14.04, p < 0.0001).

Survival curve analysis revealed highly significant differences between these groups in the training set (p < 0.0001) ( Figure 4E ).

InsuTAG scores ranged from 0.55 to 132.07 across the whole participant group with a median (25 th –75 th percentile) InsuTAG score of 7.22 (4.04–11.33) There is a strong and highly significant positive correlation between InsuTAG and HOMA-IR (r = 0.86; p < 0.0001) (Fig. 1 ) when compared with the association between HOMA-IR and the other lipid indices, TyG index (triglycerides × glucose) (r = 0.43; p < 0.001) and TG/HDL-C ratio (r = 0.38; p < 0.001) (Table 2 ).

On the treated, right (ipsi-lateral) hind paw, the CFA-treatment induced a highly significant increase in pain sensitivity on the first experimental day, MWT dropped to 2.96 ± 0.052 g ( p = 0.000101).

Expression of the NT5C2 allele in phase with the ch10_104957618_I risk allele was also reduced in all assayed adult brain regions (mean DLPFC: 15%, hippocampus: 12%, caudate: 13%), with highly significant differences in allele ratios observed between cDNA and genomic DNA that survived Bonferroni correction in all areas (DLPFC: P = 1.03 × 10 −4 , corrected P = 0.003; hippocampus: P = 2.64 × 10 −6 , corrected P = 8.46 × 10 −5 ; caudate P = 8.11 × 10 −5 , corrected P = 0.0025).