Excerpts

Moreover, highly significant differences were identified for the eraser FTO ( P =2.257x10 -4 ), the strongest obesity candidate gene identified in genetic studies ( 19 ).

The fit of the log–logistic model ( eq 2 ) was highly significant ( p -value = 2.27 × 10 –4 ) and resulted in a EC 50 value of 3.57% sediment dw (±3.22) and an EC 10 value of 1.07% ( SI Figure S3 ).

6 expected), supported by a highly significant PPI enrichment value ( p = 0.000228).

the threshold of 0.44 is highly significant (p-value = 2.3 × 10 -4 ).

Water regime under salt stress and QuitoMax application The differences in the water potentials of the varieties in the different treatments were highly significant [F = 108.5; p = 0.00023, F = 112.46; p = 0.000321 for Amalia and Claudia, respectively (Fig. 2 a and b)], and a similar response was found for the osmotic potential (F = 207.32; p = 0.00461, F = 201.31; p = 0.00117 for Amalia and Claudia, respectively).

The trend to increased cataract score with age was highly significant ( P = 2.3 × 10 −4 ).

Bias for combined K and R ending peptides is highly significant according to chi-square tests for each of the four independent analyses: delRNAs, P = 0.00023; swinger RNAs according to tricodons, P = 0.0016; tetracodons, P = 0.00000006; and pentacodons, P = 0.000038.

The bidirectional relationship between CBF and CMRO 2 was highly significant ( p = 0.00023), and both contributed to the changes in OEF.

In Part 2, we performed a Fisher’s meta-analysis of nominally significant common genes ( P- MS < 0.05, P- IS < 0.05), and 24 shared genes satisfied the strict threshold P value ( P < 2.31E-04).

The difference was already highly significant at 1 h (*** p = 0.000232), and became even more pronounced at 24 h (**** p = 0.000005).

There was a nominally significant ( p = 2.34 × 10 –4 ) association in males for rs115882880, but no evidence for association ( p > 0.05) in the opposite strata for the other two GWS associations.

Statistical testing of the overlap among the peaks of these datasets and our Satb2 ChIP-seq data revealed highly significant enrichment (adjusted p<0.00024) of active chromatin states (H4K16ac, H3K27ac, H3K4me1, H3K4me2, and H3K4me3 peaks) and PolII peaks at Satb2-bound promoters ( Figure 5C , Figure 5—figure supplement 2A ).

Further, statistical significance was observed in the STAI; state anxiety levels were significantly higher in ARFID patients compared to the HC group, while trait anxiety showed only marginal significance (STAI State: U = 46, p = 0.00024, δ = −0.72; STAI Trait: U = 100, p = 0.051, δ = −0.38) (see Fig.

The ANOVA of the Plackett-Burman design demonstrated that the model was highly significant as was evident from the Fisher’s F -test (51.910) with a very low probability value [ P- value = 0.00024] and the t -Stat of 493.355.

Out of the 24 highly significant metabolites 14 (58%) could be confirmed at the high (p < 0.00024) and 19 (79%) at the normal (p < 0.05) significance level (figure 4 ).

The corresponding OPLS-DA model was highly significant: R 2 X = 0.464, R 2 Y = 0.918, Q 2 = 0.567 and p = 0.00024 ( Figure 4 B).

Among them, rs1408705 (with borderline significance, p = 0.00024) is located in PACRG (PARK2 co-regulated), which was previously found to be deleted in clear-cell renal cell carcinomas [ 38 ].

The differences were highly significant with the Kruskal-Wallis test (p = 0.00024).

Once both of these classes of tumors were removed, the correlation between the two estimates of lifetime mutation accumulation in the remaining 28 tumor types was highly significant ( P = .00024, r=0.64).

The yield model was highly significant with a very low p=0.00025.

All four axes remained highly significant after conservative cross-family correction (all Holm-adjusted P < 2.5 × 10 -4 ), confirming that the convergent multi-omics signature associated with elevated Rad-Score — encompassing ferroptosis activation, effector immune infiltration, genomic instability, and spatially organized chemokine networks — is robust and independent of false-positive inflation across omics families.

The Chao1 index showed highly significant differences among groups ( p = 0.00025), with the HFD group exhibiting markedly reduced microbial richness compared with the ND group.

There was a highly significant correlation (r = 0.9883; p = 0.00025) between age-stratified mortality rates and IL-6 levels from previously published data on healthy individuals.

The differences were highly significant (p < 0.00025).

Importantly, while the BV/TV values of sham-operated wild-type and PLCγ2 −/− animals were statistically highly significant ( P = 0·00025), there was no significant difference between the two genotypes after the ovariectomy procedure ( P = 0·25; n = 7 (wild type) vs. 4 (PLCγ2 −/− )).