The Chao1 index showed highly significant differences among groups ( p = 0.00025), with the HFD group exhibiting markedly reduced microbial richness compared with the ND group.
Excerpts
Permutation tests showed that the effect of feeding treatment was highly significant for population growth rate ( p < 0.00025 ) and stable population structure ( p = 0.0012 ; Figure S3 and Table S1 ).
Results were statistically highly significant ( P = 0.000251, Spearman Coefficient: 0.91815).
A robust negative correlation to IC 50 ( r = −0.504) was exhibited by the Number of Hydrogen Bond Donors (NumHDonors), accompanied by a highly significant p -value ( p = 2.56e-04), which was indicative of an association between a higher count of hydrogen bond donors and enhanced compound activity.
In contrast to TMX(-) studies, here we observed a highly significant interaction between Cre-ER and Lox-Stop (p=2.59E-4), which suggested that SynGAP re-expression altered activity suppression levels.
This was markedly significant for the beta band (−0.065 ± 0.005s −1 for old – baseline v −0.034 ± 0.004s −1 for young – baseline , p = 0.00026).
One comethylation module (Bisque 4) showed a highly significant negative correlation between sample eigennode values and ASD diagnosis ( P = 2.6E−4).
For example, there is a highly significant correlation between expORChID2 values and X-ray-derived minor groove widths for the Ubx-Exd heterodimer DNA binding site, because P = 0.00026 falls below a confidence level of 0.001.
Kaplan–Meier analysis revealed a striking survival advantage for the high methylation group, with a highly significant difference in OS (log-rank p = 0.00026) (Fig. 2 d).
This SNP was statistically significantly associated with risk of CRC in our unconditional analysis ( P = 1.2×10 −4 ) but was borderline significant with respect to our pre-specified threshold in an analysis conditional on the region’s lead index-correlated variant, rs12474044 ( P = 2.6×10 −4 ).
Additionally, Campylobacter A showed nominally significant risk enhancement (IVW OR = 1.718, p = 2.64 × 10 −4 , FDR- q = 7.30 × 10 −2 , 95% CI 1.285–2.298), with no evidence of heterogeneity, pleiotropy, or reverse causation ( Tables S5 and S6 ). 3.5.
However, when we performed mediation analysis, conditioning on the expression of TOP2B , the association between CX-5461 IC 50 and MYCN expression was lost ( P = 0.8), but TOP2B remained highly significant ( P = 2.7 × 10 −4 ), suggesting that the association between MYCN and CX-5461 IC 50 was mediated through MYCN ’s effect on TOP2B expression.
Association mapping revealed highly significant marker trait associations at Bonferroni correction P < 0.00027.
Finally, there was a highly significant positive correlation ( F = 14.10; df = 1; P = 0.00027) between protein quantity and diCT sensitivity.
While this is highly significant ( p = 2.7 × 10 − 4 ), this deviation is not unexpected given the very significant differences in MAF between groups.
In reality, however, we observed a highly significant ( p = 0.00027) 56.7% increase of CldU-labeled cells in the T C running experimental groups.
A highly significant association with Gleason score was observed when the data was combined from these three studies with an Odds Ratio (OR) of 0.85 (95% CI = 0.77–0.93; p = 2.7×10 −4 ).
The difference among body mass distributions of extinct, introduced, and remaining frugivore species was highly significant (ANOVA, F 37,2 = 10.343, p = 0.00027; Kruskal–Wallis Χ 2 = 16.477, p = 0.00026, see Supplementary Fig. 1 ).
The facial lesions were found frequent in young patients below 19 years (38/61; 62.2%), while the limbs lesions were described more in older ages (≈ 86%), with highly significant differences observed among the patients age groups ( P =0 .000273, chi-square).
The highly significant differences occurred between SF of 2 Gy and SF of 2 Gy + RGD-PEG 2000 -AuNPs 30nm ( p = 0.000275) and 2 Gy + RGD-PEG 2000 -AuNPs 10nm ( p = 0.00016).
The difference in DogCV prevalence was highly significant ( P = 0.0002755) in diarrheal dogs.
If we consider the trends being predicted by nucleotide content as being a “success”, then this pattern (16 successes, 1 fail) is highly significant (binomial test P -value = 0.00028).
The most significant pathway (P = 0.00001) related to the biology of the innate and adaptive cellular immune response ( Table 2 ), followed by the adaptive response (P = 0.00023) and a number of highly significant and closely related pathways relating to polymorphism in the Fibroblast Growth Factor receptors (FGFR) and their ligands (minimum P = 0.00028).
[ 60 ] for intellectual disability, developmental delay, and/or ASD, DOCK8 is nominally significant for deletions ( P = 0.000281) but not duplications.
The ANOVA Welch test demonstrated that there were highly significant differences between these total BA values ( Table 3 ), as expected ( p = 2.84 × 10 −4 ); such differences were largely explicable by those observed between the cheese and wine/vinegar product classifications investigated.