Excerpts

This relationship remained and was more highly significant in the sensitivity analysis with only one record per patient and the average CT included in the model (–0.07; P = 0.0002).

1 B, there was a highly significant correlation (R = 0.74, p = 0.0002) between body weight and liver PAR2 expression in PAR2 ΔHep mice vs. wild-type (WT; PAR2 fl/fl ).

In an analysis of subgroups according to grade, no difference in terms of occurrence of metastatic disease was observed for grade 1 and 2 tumours between the treatment periods, whereas a highly significant increase in the number of patients with metastases for grade 3 tumours was noted in the recent period ( p = 0.0002).

The median plaque score difference on the 100 th day between the two groups was highly significant (p ≤0.0002).

Using a meta-regression model (Section 2, Model 1) where publication date is the sole moderator, we find that the date of publication demonstrates a negative trend that accounts for 91.8% of the heterogeneity between studies (B = −0.166 [−0.254, −0.078], Q m = 13.72, p = 0.0002, k ES = 14 effect sizes, n = 206, τ resid = 0.110, see Figure 2A and Table 3 ).

8 ), and this difference was highly significant ( N =16; t=4.87; P =0.0002).

A highly significant difference in distribution of deaths by suicide (χ 2 = 36.20, df = 11, p = 0.0002) was shown, which were found in both genders (Male: χ 2 = 21.00, df = 11, p = 0.0335; Female: χ 2 = 47.74, df = 11, p = 0.00002).

The latter set (of 1286 nominally significant mouse trans -genes) was significantly enriched for overlap with the human trans-network (P<2x10 -4 ).

Post-hoc analysis of the marginally significant interaction (T x Day, Table 2 ) revealed significant effects of temperature on Day 11 (linear contrast with Bonferroni correction; Ζ = −4.045, p = 0.0002), but no difference between temperatures on Days 9 and 10.

However, at higher HA wt% (50 and 75), there was a large, highly significant increase in compressive modulus (13.7 and 33.6 MPa, respectively, P < 0.0002 for both).

miR-125a-5p showed a highly significant association, with a genetically predicted increase in expression associated with a 26% reduction in AD risk (OR = 0.74, 95% CI: 0.64–0.87, P=2.05e−4).

Interfascial injections demonstrated lower pressure variability ( p = 2.1 × 10 −4 ) and an increasing trend in pressure over time ( p = 2.1 × 10 −4 ), whereas intramuscular injections exhibited a decreasing pressure trend ( p = 3.15 × 10 −3 ).

For Model 1, the fit was highly significant (t(54) = 3.98, p = .00021), whereas the fit for Model 2 only bordered significance (t(54) = 1.88, p = .066).

The findings demonstrate significant variances between stage I and II ( P = 0.027), highly significant variances between stage I and III ( P = 0.00021), and extremely significant variances between stage I and IV ( P = 0.0054).

Overall, the Leu372Val substitution had a highly significant effect on surface expression (ANOVA, p = 0.00021), while there was no effect ascribable to the Thr357Ala replacement (p = 0.579).

We found that FoxC1-induced genes were enriched among native SGCs relative to ECs, and that this enrichment was highly significant ( P = 2.1 × 10 –4 ).

For nominally significant SNPs or genes, we considered a recessive model with a Bonferroni corrected threshold of P = 2.1 × 10 −4 .

Three additional associations were borderline significant after multiple testing: a PRS for high blood pressure was associated with renal cell carcinoma (OR = 1.20, p = 2.10 × 10 –4 ), a PRS for deep vein thrombosis had the most significant association with pancreatic cancer (OR = 1.13, p = 1.10 × 10 –4 ), and a PRS for peripheral artery disease was associated with lower risk for glioma (OR = 0.90, p = 2.10 × 10 –5 ; note because other cancers were used as a control this could alternatively be interpreted as high risk for non-glioma cancers.

As discussed in Results , the identification of 10 of 54 genes with a link to HIV-1 replication is a highly significant over-representation (p value<0.00021) over the expected number (2.4) in randomly generated lists of 54 genes that are expressed in both Jurkat and MM6 cells.

Three markers were nominally significant (P-value = 0.00021–0.011; Table S7 ).

Instead, there was a highly significant relationship between serum IFN-α and LRRC20 genotype in a joint analysis of European- and Hispanic-American subjects ( P = 2.1 × 10 -4 ), in whom the serologic association with anti-La antibodies was not present (Supplemental figure S2 in Additional file 1 ).

On the other hand, the WSS change on the superior side between the control and LAL embryos is determined as quite significant ( p = 0.00022).

The difference between the two groups was highly significant ( p = 0.00022), with a mean difference (−1.801 kcal/mol) substantially exceeding the inherent noise level of the scoring protocol.

Since duration apparently influenced the success of mountings, we tested for an effect of location and found a highly significant male species × female species × location interaction (χ 2 = 18.89, df = 1, P = 0.00022), driven mainly by short interspecific matings in the sympatric, but not in the allopatric combinations (Fig. 1 A).

For example, the protective effect of CCBs on dental caries risk in the FinnGen cohort remained highly significant in the MR‐PRESSO analysis (OR: 0.9709; 95% CI: 0.9503–0.9837; p = 2.23 × 10 −4 ) reinforcing the validity of our primary findings. 3.3.