In all these comparisons, the difference between control antibody and fremanezumab was highly significant (F 1,62/64 = 21.40–23.68, p < 0.0005) but there was no difference between the three trigeminal partitions V1-V3 (F 2,62 = 0.80, p = 0.45), between females and males (F 1,64 = 0.65, p = 0.42) and between different waiting times (F 1,64 = 0.64, p = 0.43).
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The results revealed that the relative levels of EGFP protein expression in cells harbouring the pSSB vector were significantly lower than those in cells transfected with the pSB vector, with the difference being highly significant ( p < 0.0005).
The difference in level of relatedness between breeding pairs and random pairs was estimated at 0.07 and was highly significant (10,000 simulations, one-sided p -value = 0.0005).
Faroese smokers tended to have higher T than non-smokers (p=0.7, adjusted for BMI effect), whereas the effect on the Danish men were highly significant (p<0.0005).
Conclusion From the above concrete observations, it can be hypothesized that AHCC is promoting proliferation and differentiation of leukocytes (multipotent stem cells), as it is seen that the genes responsible for these such as LAT, FLRT2, GIT-1, and so forth, as seen in Figure 5 , are upregulated and highly significant ( P < 0.0005).
Although we did not look at the ratio of plasma tryptophan to other large neutral amino acids, the differences between total blood plasma tryptophan levels with (5–8 μmol/L) and without (51–182 μmol/L) ATD were highly significant ( p < 0.0005, Wilcoxon rank-sum test).
Serotonin There was a highly significant ( F (1109) = 23.15, p < 0.0005) main effect of genotype on midbrain serotonin levels with wildtype controls averaging 408.3 ± 9.0 and the MTKO mice averaging 476.1 ± 10.0 (Fig. 6b ).
Overall, we found a highly significant negative relationship between competitive success and yield in monoculture (linear regression; F 1,18 =27.117, R 2 =0.601, P <0.0005; Fig. 4b ).
The most striking impact of dialysis modality was on change in albumin, which was highly significant for PD patients ( p = 0.0005), but not HD patients ( p = 0.34).
On the contrary, the combination of all three miRNAs ( figure 4D ) revealed a fair but highly significant AUC value (0.72, p=0.0005), with a specificity of 0.83 and a sensitivity of 0.57.
Comparison between rapamycin and HI treatment revealed opposed effects with highly significant difference ( p = 0.0005; Figure 5A ).
These predisposing patterns appeared to be associated with a highly significant increase in colorectal cancer, either compared to the reference pattern alone (OR 2.65; 95% CI 1.58–4.42 with p = 0.0005), or compared to reference and mixed patterns gathered (OR 1.97; 95% CI 1.31–2.97 with p = 0.0009).
The exponential model on a log e H vs Y scale also demonstrated a highly significant linear relationship (F 1,5 = 137.08, P < 0.0005, R 2 = 0.97), with a slope of −0.1635 (95%CI -0.1994 to −0.1276) and an intercept of 333.1882 (95%CI 261.1155 to 405.2608).
Fitting a mixed-effects model with Šídák’s post-hoc test comparing the time to diagnosis of radiologists and neurosurgeons, a highly significant effect was discovered in patient’s heterogeneity (p = 0.0005), but not in the training of the rater (p = 0.74).
However, the landscape was roughly the same at 1 and 2 km, as shown by the highly significant correlations of the variables at the two scales (all P-values < 0.0005; r = 0.85, 0.88 and 0.71, for percentage of natural habitats, crops and landscape heterogeneity respectively).
There was a highly significant statistical correlation ( p < 0.0005) between RPA2 and γH2AX (Table 1 ).
We correlated the tdTomato/YFP ratios with survival time and noticed that infected cells with a shorter survival time tended to be cells with a low ratio of tdTomato/YFP expression (Figure 6 B), and Spearman test resulted in a highly significant correlation index (r = 0.28, p = 0.0005), arguing that LSEC-uniLT that expressed relatively more YFP than tdTomato lysed earlier than cells that expressed more tdTomato.
However, creatine kinase continued to exhibit a highly significant increase in group [D] vs. group [C] (*** p = 0.0005) (Fig. 5 C-b).
There was also a significant trend ( P = 0.0005) of increasing PC3 level with increasing pack-year category (Table 6 ).
Observable differences are highly significant; performing one-sided Mann-Whitney U tests (with the alternative hypothesis c treated > c untreated ) leads to the rejection of the null-hypothesis (p < 5 x 10 −4 ) for all metabolites.
The difference in the number of mice developing an amebic liver abscess between HDP-1 immunized SCID mice and SCID mice receiving antibody EH5 was highly significant ( P <0.0005).
The result of the Friedman’s test was highly significant ( P =0.0005).
In conclusion, estimating the relatedness of the spore inoculum to paternal genomes of harvested fruitbodies (hypothesis H3) revealed a not significant relationship at Site 1 and Site 2 but a highly significant at site 3 (r = 0.417, p -value < 5e− 4; Table 2 ).
The analysis of population structure by means of Wright’s [ 23 ] F ST statistic (0.42) was highly significant ( P = 5x10 -4 ).
Upregulated genes grouped into 75 highly significant categories (selected according to p <0.0005 and at least 10 genes per category, S2 Table ), of which 22 (29%) were involved in the development, growth or death of brain cells, functions of the nervous system (e.g., behavior, cognition, or mood disorders) and/or the amount of neurotransmitters ( Table 1A ).