In a multivariable analysis of EFS including pre-transplant IDDA v2.1 ≤ 14 / ≥15 and HCT-CI ≤ 2 / ≥3 and the interaction between these prognostic factors, as well as age at transplant and date of transplant, neither IDDA v2.1 ( p = 0.059, HR = 4.6) nor HCT-CI ( p = 0.057, HR = 7.1) were independently significant, but the interaction between these two factors combined (HCT-CI ≥ 3 and IDDA v2.1 ≥ 15) was highly significant ( p = 0.0005, HR = 18.0), Fig. 3 H.
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3C , and revealed highly significant changes as a function of gestational age (p < 0.0005) and mouse model (p < 0.0005).
A one-way ANOVA showed a highly significant cohort effect ( F = 14.20, p = .0005, η 2 = 0.69), and a pairwise post-hoc Tukey-HSD test computed with the onset indices for the ND-CI and AD-CI cohorts were not significantly different ( p = .98), but did reveal a significant difference between ND-CI and NH-acoustic ( p = .0007) and AD-CI and NH-acoustic ( p = .0018).
All lead variables had highly significant effects on IQ ( p < 0.0005) in the models.
Effect of drug on peak Lip10 stain index comparing the results from subjects receiving placebo versus subjects receiving 100 mg was highly significant ( p = 0.0005, Kruskal–Wallis).
Results Multiple comparisons using one-way analysis of variance (ANOVA) between the materials on day zero, 45 th and 90 th day was highly significant with p=0.0005.
In contrast, the singly butylated peptide ( 16 ) caused highly significant (P < 0.0005) apoptosis in a concentration dependent manner.
2013 ), showcasing a robust agreement with a κ-value of ≥ 0.750, coupled with a highly significant p -value of < 0.0005.
In contrast, Lr GtfC 100-23 W240C showed a highly significant positive thermal shift in the presence of both UDP-GlcNAc or UDP-Glc ( p < 0.0005).
Risk of LE rose across the cardiovascular disease risk scores in a highly significant trend ( p = 0.0005) (see Fig. 1 ).
The magnitude of the association is as high as 6-fold with a strong trend across the CVD risk scores ( p = 0.0005).
Ten of the transcripts were found to be differentially expressed in the same direction as in the RNA seq experiments; for three of the transcripts ( APOBEC3A , PLSCR1, IL1RN) , the fold change differences were statistically significant or close to the level of significance (p = 0.0005, p = 0.0489, p = 0.0507, respectively, Mann–Whitney test).
There was a highly significant TRAINING effect (F 1,10 = 288.3, p<0.0005).
In addition, the net reclassification improvement and integrated discrimination improvement were highly significant in all multimarker lipid panels alone and when added to the base model in the training set ( P ≤ 0.0005), an observation that was reproduced in the test set using the models that were developed in the training set.
This shift was highly significant in both treatment groups ( P < 0.0005) and was stable over time.
There was a highly significant statistical correlation ( p < 0.0005) between RPA2 and γH2AX (Table 1 ).
These findings suggest that the potent antitumor activity of irinotecan is further enhanced by TG6002/5-FC, with the combination showing highly significant efficacy compared to controls ( p < 0.0005).
Using the cohorts from PARIS and Canada and the ExAC data set, the enrichment of rare CNTN6 variants in individuals with ASD compared with the general population was highly significant (ASD: 18/501; 3.59% controls: 535/33 480; 1.6% P =0.0005) and with an achieved power to observe such a difference of 87%.
6 ) and PLS-DA model validation by permutation tests was highly significant (p < 5e-04).
In all figures, we marked the permutation test results as follows: If the number of failures was, for example, 1 in 10,000 ( p = 0.0001) or less, it was marked as highly significant (***), 5 in 10,000 ( p = 0.0005) or less, as significant (**), and 10 in 10,000 ( p = 0.001) or less, as weakly significant (*).
Serum MDA levels were found to be higher (6.846 ± 1.5) than controls (4.588 ± 1.17) while SOD levels were found to be lower in women with miscarriage (2.26 ± 0.66) than that of control group (3.16 ± 1.13) and difference were found to be highly significant ( P = 0.0005, <0.0001), respectively.
In contrast, PMA triggered a much larger increase in the C/N ratio of eERK-KTR1.2/emiRFP670, from ∼0.7 to ∼1.7, which was highly significant ( p = 5 × 10 −4 ).
The differences in menstrual volume and ferritin levels at baseline, compared to the menstrual volumes and ferritin levels at 12 and 24 months, respectively, were highly significant ( P <0.0005).
However, at subsequent time points, highly significant differences ( P <0.0005) in total body weight and fat mass were evident for both sexes, further confirming the impact of the HFD on body composition.
Nevertheless, in an independent series of experiments, registering only the total numbers of eggs produced by each female after their death, we observed a highly significant and consistent decrease ( p < 0.0005; unpaired T-test) in the number of eggs laid by females injected with ds RpCht7 (average 39) when compared to females injected with ds GFP (average 18).