Excerpts

The results showed that patient identity had no significant effect ( P = 0.336), while time had a highly significant effect ( P = 9.00e-4).

An intronic marker in IRF6 (rs2073487) also showed a trend for association with complete left cleft lip/palate (P = 0.0009).

On the basis of the previously observed frequency (3/8) of 2D colorectal cancer cell lines demonstrating CIITA methylation, this result of zero of 15 organoids nonmethylated is highly significant (probability-based P = 0.0009; Fisher exact P = 0.032).

It was stopped before completion for ethical reasons because there was a strong and highly significant positive difference for rC1-INH versus placebo in median time to beginning of relief (62 versus 508 min, P = 0.0009) as well as time to minimal symptoms (480 versus 1480 min, P = 0.0038).

Based on these data, we analysed via Kruskal-Wallis nonparametric test the correlation between [ 11 C]-MET mean uptake index and histological grading, whose results are absolutely significant ( P = 0.0009).

The striking association with PD-1 inhibitors (RR: 24.84; 95% CI: 16.92-36.48), IFN-α2b (RR: 3.10; 95% CI: 1.53-6.30), and CTLA-4 inhibitors (RR: 32.042; 95% CI: 18.052-56.875) were all highly significant (p<0.0009), highlighting a consistent biological signal.

These correlated negatively with the CC1-L/CathG ratio ( r = –0.2075, P = 0.2050; Figure 11B ) while showing a highly significant positive correlation with sAST ( r = 0.5107, P = 0.0009; Figure 11C ) and sALT ( r = 0.6360, P < 0.0001; Figure 11D ) at POD1.

At Day 12, highly significant reductions were observed in tumor width (*** p = 0.0009), length (** p = 0.0017), and volume (*** p = 0.0007) relative to control, whereas the tablet showed only modest effects on width (* p = 0.036) and volume (* p = 0.0379) and no significant effect on length ( p = 0.2243).

Nevertheless, there was highly significant (p = 0.0009) and moderate heterogeneity ( I 2 = 46%) among studies.

This observation was supported by the extremely significant quantitative difference in the H 2 O 2 production before and after passing the phase transition point: R = 0.7124, p < 0.0009 (n = 18) (Table 5 ).

Pairwise F ST comparisons of the Dokdo Island population with other local populations indicated highly significant differences after the Bonferroni correction was applied ( p < .0009), with a range of 0.0175 (Wangdolcho Reef) to 0.0639 (Chujado Island; Table 3 ).

Overall highly significant correlation of PTEN sequencing results with PTEN immunochemistry was demonstrated ( P = 0.0009; Fisher's exact test).

However, for three genes, the strength of association with a burden of rare variants was more significant than observed for a single variant test, and in each case, a second nominally significant SNP was observed; LIPG p.Arg476Trp for HDL cholesterol (MAF = 0.18%, P = 9×10 −4 ), LIPC p.Arg208His for LDL cholesterol (MAF = 0.16%, P = 0.02), and ANGPTL4 p.Arg336Cys for triglycerides (MAF = 0.24%, P = 0. 01).

Our analyses did yield numerous highly significant p ‐values, however, and the top hit was TROY (TNFRSF19; p = 0.0009, FDR Q = 0.227), which declined with age (Figure 2A ).

post-earthquake differences in species abundance were highly significant ( Supplementary Table 3 ; pairwise tests after significant one-way PERMANOVA: 1997 vs. 2012: P = 0.0009; 2005 vs. 2012: P = 0.0015), while differences between the two pre-seismic samplings remained non-significant (1997 vs. 2005: P = 0.5131).

In addition, a Mann-Whitney U test, as modified by Gao and Allison [ 6 ], which was newly implemented in OASIS 2, showed that the difference in maximal lifespan was highly significant ( P = 9.0×10 −4 ; Figure 1D ).

In contrast, the study results indicated highly significant correlations between SM and chronic disease (χ 2 = 10.846, p = .0009) as well as the absence of medical insurance (χ 2 = 84.175, p = .0001) ( Table 4 ).

Indeed, the relative similarity score was highly significant (score = 0.82, p = 0.0009), indicating direct TBX3 binding to the Lef1 promoter, most likely triggering its transcriptional repression (Fig. 5 l).

The difference in diversity was highly significant (t = 3.34, df = 501.72, p = 0.0009).

The association between RLS and cryptogenic events in patients older than 60 years found in the OXVASC study (based on 112 detected PFOs) was consistent with two previous smaller bubble-TCD studies of older age groups (based on 44 28 and 31 29 PFOs; figure 1 ), yielding a highly significant pooled estimate (OR 2·35, 95% CI 1·42–3·90; p=0·0009; p heterogeneity =0·15).

None of the recurrent smokers continued smoking during the study period and showed a highly significant difference ( p = 0.0009) when compared with the non-recurrent smokers.

This difference is highly significant (p = 0.0009), suggesting that the appearance of AThTP is linked to the presence of ThTP.

In contrast, the Digit Span Backward (Number of Correct Responses) revealed significant improvements in both the right ATL group ( p = 0.025) and the left ATL group ( p = 0.014), with an overall highly significant improvement observed across both groups ( p = 0.0009).

While shoot biomass was still positively correlated with root parameters and transpiration, an increasing root-to-shoot ratio had a highly significant and negative correlation with transpiration ( r =-0.7, p = 0.0009).

The abnormal scores and frequencies of falls in EquiTest conditions 5 and 6 were highly significant, with a p = 0.0009.