Excerpts

On control surfaces, a highly significant increase in plaque accumulation was observed from Day 1 to Day 2 ( p = 0.0009), then a constant increase occurred each day until Day 5.

Wilcoxon's signed rank test showed a highly significant difference comparing the joint group of goiters and benign tumors with malignant tumors ( p = 0.0009).

Although the treated groups also exhibited an increase, the change did not reach statistical significance compared with that of the CPZ + Vehicle group ( P = 0.0009) (interaction F (8, 50) = 3.850, P = 0.0014; time F (1.876, 46.91) = 17.61, P < 0.0001; treatment F (4, 25) = 8.022, P = 0.0003; Fig. 2 D).

For the Chinese HP the median difference between the correct identifications of the SIT-12 (10.0 (2.0)) and Ch-SIT-12 (11.0 (1.25) was highly significant (p<0.0009).

However, for three genes, the strength of association with a burden of rare variants was more significant than observed for a single variant test, and in each case, a second nominally significant SNP was observed; LIPG p.Arg476Trp for HDL cholesterol (MAF = 0.18%, P = 9×10 −4 ), LIPC p.Arg208His for LDL cholesterol (MAF = 0.16%, P = 0.02), and ANGPTL4 p.Arg336Cys for triglycerides (MAF = 0.24%, P = 0. 01).

When conducting a Pearson's correlation analysis, a strong positive and highly significant relationship between SV2A protein levels, as detected by ELISA, and mRNA levels in the cerebral cortex as conducted by RT‐qPCR ( r = 0.56, p = 0.0009, n = 32) and hippocampal ( r = 0.48, p = 0.004, n = 32) homogenates were observed (Figure 5A, B ). ′′The [3H]UCB‐J binding level showed a strong positive correlation with the SV2A protein level in the cerebral cortex ( r = 0.76; p < 0.0001, n = 20), but no significant correlation was found in the hippocampus ( r = 0.35, p = 0.13, n = 20) (Figure 5C, D ).

Regarding oral agmatine treatment, one-way ANOVA revealed a highly significant difference between the four dose groups ( P < 0.0009) with dose-dependent increases (2–7 folds) and higher agmatine levels at the 600 ( P < 0.01) and 900 ( P < 0.001) mg/kg doses.

In contrast, the study results indicated highly significant correlations between SM and chronic disease (χ 2 = 10.846, p = .0009) as well as the absence of medical insurance (χ 2 = 84.175, p = .0001) ( Table 4 ).

There was no decline in serum IL-1β levels after three months therapy with IVA/LUM ( Figure 2B ), and yet IVA/TEZ treatment resulted in a highly significant reduction in serum IL-1β (p=0.0009, Figure 2F ; compare 2B).

This association remained highly significant (p = .0009) even when controlling for demographics, self-reported health status, educational attainment, race, marital status, self-reported knowledge of medications and health, number of OTC medications used, income, and attitude toward DTC advertisements see Figure 1 .

The association between RLS and cryptogenic events in patients older than 60 years found in the OXVASC study (based on 112 detected PFOs) was consistent with two previous smaller bubble-TCD studies of older age groups (based on 44 28 and 31 29 PFOs; figure 1 ), yielding a highly significant pooled estimate (OR 2·35, 95% CI 1·42–3·90; p=0·0009; p heterogeneity =0·15).

The full model was highly significant ( P value = 0.0009), and many individual parameter estimates were significant, notably in the M. galloprovincialis lineage ( table 3 ).

The deletions of 10q11.22 (CNV_4) demonstrated a highly significant association with the risk of childhood obesity in our study ( p = 9.1 × 10 −4 ).

Regional and whole‐brain voxel‐wise analyses After extracting the correlations between the GMVs of 90 cerebral regions in the AAL atlas (Tzourio‐Mazoyer et al., 2002 ) and auditory comprehension scores, with age, sex, and total intracranial volume effects removed, we found that the grey matter in the posterior temporal lobe had a fairly significant correlation with auditory comprehension, especially in MTG and ITG, with r = 0.529, p = 9.1 × 10 −4 and r = 0.541, p = 6.6 × 10 −4 , respectively, Bonferroni corrected.

The overall average gene gains and losses show a clear trend of fewer genes gained by thermophilic fungi (2.23 times fewer genes gained than mesophilic, p = 0.00091 - [WT]), and more genes lost (1.06 times more genes lost than mesophilic, p = 0.6361 - [WT]); and the opposite trend in mesophilic fungi.

Upright-assisted elevation exercises were found to generate significantly more anterior deltoid activity than that of all gravity-minimized exercises ( Table 4 ); one exception to this result was the rope and pulley exercise (30% ± 12% MVIC), which was not different from side-lying elevation exercise (16% ± 7% MVIC) but approached significance ( P = .00092).

Notably, IL-13 exhibited a highly significant raw P -value ( P = 9.25 × 10−4), further supporting its potential causal role, yet no outliers were detected, reinforcing the validity of the IVW results.

Using the same statistics as in TADs ( Permutation Test ), the overlapping between LADs and isochores is highly significant (p = 0.00093).

final echo decorrelation ( r = 0.102 , RMS error 0.122, p = 0.520 ), but were highly significant for ablation rate vs. decorrelation ( r = 0.331 , RMS error 0.352 ml min −1 , p = 9.3 × 10 - 4 ).

Subsequent analysis by Linear Regression was highly significant with p = 9.40×10 −4 , and empirical p -value calculation by 10,000 permutations of 1.0×10 −3 .

There were two p -values (after adjustment) that were highly significant by the edge-count test: p =9.4×10 −4 for H 0 : F luminal A ∗ = F luminal B ∗ and p =1.1×10 −3 for H 0 : F basal − like ∗ = F luminal B ∗ .

p value = 1.34E-04) and a nominally significant decrease in de novo PD vs. control ( p value = 9.41E-04; adj. p value = 5.86E-02), is a furan fatty acid previously suggested as a marker for fish oil intake 28 , which could indicate a diet with high levels of omega-3 fatty acids.

Kaplan Meier analysis revealed a significantly reduced risk of all-cause mortality, while the reduction in composite kidney outcome showed only a trend and did not reach statistical significance ( P = 0.00095, P = 0.065, respectively).

Another GSDMB SNP rs11078927 (intronic) showed similar findings with asthma but did not reach statistical significance (p = 9.5×10 -4 , z = -3.23) although this SNP was significantly associated with FEV 1 (% Predicted) (p = 8.7×10 -4 , z = -3.33).

The results show a highly significant value for the paired t -test of intervention Group B and control Group C of the cases ( P = 0.000957).