Excerpts

Of note, in agreement with the known relationship between ΔAUC CP /ΔAUC GLU and GLUSENS in the general population, in our population of renal transplant patients, we also observed a quite high correlation between the two, as mirrored by the highly significant p -value ( p = 2.22 × 10 −35 ).

The average methylation level of the 4 hyper-methylated genes showed highly significant difference between breast tumor and matched normal tissues ( P = 3.54E-35) (Figure 1 ).

The different response to hc‐IEDs for sample entropy and delta power was highly significant ( p = 6.3 × 10 −35 , Wilcoxon rank‐sum test).

This may be the source of the highly significant association signal we observed in our dataset for all three genetic models (DOM: P = 9.33×10 −35 ; ADD: P = 7.48×10 −30 ; REC: P = 5.27×10 −6 ).

A transcriptional network was subsequently identified (Cell Morphology, Cellular Assembly and Organization, Nervous System Development and Function) which comprised 35 eV-enriched mRNA transcripts and was highly significant (p = 10 –34 ) (Fig. 5 and Table 4 ).

However, a single SNP on chromosome 9 (at position 20,550,439) was noticeable for its strong and highly significant effect (P = 10 −34 ).

Although the performance gain was quite small when DNA shape was already included in the model, it was highly significant ( P < 1.549 × 10 −34 for sequence+MGW+EP versus sequence+MGW models; P < 4.569 × 10 −41 for sequence+shape+EP versus sequence+shape models; P < 6.748 × 10 −4 for sequence+3shapes+EP versus sequence+shape).

Our analysis revealed a highly significant ( P = 1.67e–34) overlap between AS events regulated in si Ewsr1 -N2A cells and those differentially spliced upon neuron differentiation in vivo , with 49 events in common between the two datasets (Figure 6B ).

There was highly significant non-independence ( P-value = 1.8 × 10 −34 ) between the two predictions, driven primarily by the large proportion (66%) of SNPs predicted to be benign by PolyPhen and tolerant by SIFT.

In the liver, six highly significant modules were identified ( Figure 4 A–D and Figure S6 ): MEbrown (cor = 0.85, p = 2.3 × 10 −34 ; transcripts no. = 119), MEblack (cor = 0.83, p = 1 × 10 −200 ; transcripts no. = 925), MEcyan (cor = 0.54, p = 0.0012; transcripts no. = 33), MEsalmon (cor = 0.63, p = 8.5 × 10 −05 ; transcripts no. = 33), MEgreen (cor = 0.68, p = 3.1 × 10 −22 ; transcripts no. = 154), and MEgreenyellow (cor = 0.34, p = 0.049; transcripts no. = 34) ( Figure S7A–F and Figure 4 E–K).

The enrichment of upregulated SFs in the upregulated genes is statistically highly significant ( P < 3.517 × 10 −34 , hypergeometric test).

The final age prediction model, using simultaneously the 5 CpG sites, showed a high correlation coefficient (R = 0.982), highly significant (p = 3.63e-34), explaining 96.4% of age variation.

S6 ) and highly significant ( p = 5.1 × 10 −34 , Fischer’s exact test).

A second, highly significant set of associated variants in 1q32.2 was defined by the lead SNP rs570516915 ( P = 5.25 × 10 –34 , OR = 8.65, Fig. 2b ).

After using k-means clustering to assign individuals to two different groups according to their coordinates in the PCoA, a highly significant association ( P = 5.41 × 10 -34 ) between the k-means assignments (n cluster1 = 531, n cluster2 = 118) and breeding program subgroups (n subgroup1 = 352, n subgroup2 = 297) was found.

This represented a highly significant difference (two-way analysis of variance (ANOVA) with factors young/adult stage, and individual monkey; F 1,304 =189.7 for main effect of stage, P =7.2 × 10 −34 ).

The results revealed an important positive correlation with a coefficient of determination R 2 = 0.72 and a highly significant p-value (p = 7.51 × 10 −34 ), indicating a robust linear relationship.

Other highly significant pathways included skeletal system development ( p = 8.431 × 10 −34 ), cartilage development ( p = 8.904 × 10 −34 ), and ossification ( p = 1.231 × 10 −33 ).

This analysis revealed a novel variant, rs148726219, located on chromosome 19q13.32 (>500 kb from APOE ) which showed highly significant association with AD in DF3 (p = 8.9e-34, OR = 2.5) and had further increased significance in the later release DF6 (p = 2.7e-54).

All canonical correlations were highly significant: schizophrenia: r = 0.07, P = 8.98 × 10 −34 ; bipolar disorder: r = 0.07, P = 1.53 × 10 −35 ; autism: r = 0.06, P = 7.87 × 10 −24 ; attention-deficit/hyperactivity disorder: r = 0.08, P = 7.84 × 10 −44 ; left-handedness: r = 0.07, P = 1.74 × 10 −31 ; Alzheimer’s disease: r = 0.07, P = 4.14 × 10 −33 ; amyotrophic lateral sclerosis: r = 0.06, P = 1.29 × 10 −25 ; epilepsy: r = 0.05, P = 1.49 × 10 −20 .

The variants (rs16847897 and rs10936599) of telomerase complex showed highly significant association ( p- value = 9.4E-34, OR = 5.04 (3.88–6.55) at 95%CI) with T2D.

Support Vector Machines achieved 84.06% accuracy and 93.56% sensitivity, with highly significant group differences across all features ( p < 10 −33 ; Cohen's | d | = 0.87–1.51).

Notably, there is highly significant overlap ( P < 1 × 10 −33 ) between the WHSC1 target genes identified and the differentially expressed genes in KMS-11/Cfz (86 out of 887; FC ≥ 1.4) and KMS-34/Cfz (69 out of 888 genes, FC ≥ 1.5).

cholerae and rotavirus was highly significant (p = 1.12 × 10 –33 ).

Further analysis of the differentially methylated probes in all primary human keratinocytes from 13 different donors also showed a moderate, but robust and highly significant ( p = 1.4 × 10 −33 , t -test) reduction of DNA methylation in the DHM-treated cells ( Figure 2B ).