While the quinine-rs10772420 association remained highly significant after conditioning on the lead SNP for caffeine (P = 3.0e-19), a weak quinine-rs2597979 association remained after conditioning on rs10772420 ( P = 0.044).
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Interestingly, in the RPPA study of LUAD carcinomas, machine learning provided a highly significant signature of metastasis ( p = 3.17 10 −19 ) that included the expression of β-F1-ATPase, IF1, superoxide dismutase (SOD2), thioredoxin (TRX), peroxiredoxin 6 (PRX6) and 4-hydroxynonenal (4-HNE) modification of proteins [ 20 ].
50 We detected a highly significant positive correlation (R = 0.2676, p = 3.22 × 10 −19 by Spearman correlation test) between the magnitude of IFN-γ response to a given peptide and the number of HLAs to which it was predicted to bind ( Figure 1 C).
Reassuringly, the study also reported highly significant association of a previously reported SNP in TCF7L2 in Sikhs ( P = 3.3 × 10 −19 ) and confirmed a previously reported IGF2BP2 locus, with these two loci also showing genome-wide significant association with T2D in combined meta-analysis of the Sikh and wider South-Asian populations, and large, multiethnic meta-analyses.
ato -correlated genes at t3 represent 3.0% of the genome but include 10.1% of DCBB genes—a highly significant over-representation ( p = 3.3×10 −19 ) ( Table 1 ).
The sodium-potassium ATPase subunit alpha 2 gene ( ATP1A2 ) was highly significant in the case-control comparison ( p < 4 × 10 −19 ).
Comparison of the WP and ACRG subclusters revealed that 67.39% (31/46) of MSS/EMT patients corresponded to the EMT cluster, whereas 73.42% (58/79) of MSS/TP53+ patients associated with the metabolism cluster, contributing to a highly significant statistical correlation between WP subclassification and ACRG subtyping ( P = 4.6 × 10 −19 ) (Tables S4 and S5 , Fig. 3A,B ).
DNM’s showed no enrichment of synonymous or tolerated missense variants (“T-mis”), but highly significant enrichment for both LOF (1.49-fold enriched, P = 4.63 × 10 −19 ) and damaging missense (D-mis) DNMs (1.35-fold enriched, P = 1.24 × 10 −13 ) ( SI Appendix , Table S4A ).
As can be seen, the difference between the mean final values of A (conditions in which the reaction is pre-specified) is highly significant ( p = 4.71×10 −19 ), whilst the difference between the mean final values of R (conditions in which the reaction is pre-specified) is not ( p = 0.175).
Further, when smaller geographical areas were considered (France is divided into 96 administrative units, called departments), these correlations remained highly significant (e.g., admissions to CCRUs: R smell = 0.76, p < 5 × 10 −19 ) (Fig. 1c ).
We found this CpG site highly significant in our sample of predominantly AA ( t = − 8.911; p = 5.074E−19).
Here, over all animal groups, ∆f% had a marginally significant effect on the ENV/TFS log-z-ratio [main effect: F(1,943) = 4.278, p =0.039] and stimulus condition had a highly significant effect on the ENV/TFS log-z-ratio [main effect: F(2,943) = 43.929, p =5.744 × 10 –19 ].
Ranking of patient samples by relative expression of these 54 genes identified high and low expressers, with the top 10% and the bottom 10% exhibiting a highly significant ( p = 5.79E-19) 8.9-fold difference in expression levels (Fig. 1 B, C).
We noted that the overlap between the TADA2B-correlated genes and our top 100 hESC CRISPR screen hits was highly significant ( P = 6 × 10 −19 ).
15 We also used the UMCG Groningen Gene Network tool which analyses data from 80 000 Gene Expression Omnibus microarrays to predict gene function in Gene Ontology Consortium terms, and found the top-scoring predictions for ARMC4 were highly significant and all involved in cilia functions: ciliary or flagella motility (p=6.10×10 −19 ), microtubule-based movement (p=1.16×10 −9 ) and cilium assembly (p=1.16×10 −9 ).
MIR1307 also maps to a highly significant SCZ GWAS locus (rs11191419, p value = 6.198e−19) in the PGC2 meta-analysis 30 .
We observed a moderate, but highly significant, correlation ( R Pearson = 0.4; P = 6.6 × 10 −19 ) between the TGS of the 461 genes in our study and their corresponding posterior probabilities [ 23 ] (Fig. 4c ).
Given the overall rates of linkage to both loci, we would expect less than one overlap by chance, and the observed overlap of 12 genes is highly significant (Fisher exact p -value = 8 × 10 −19 ).
Overall there is a highly significant overlap between differentially expressed and high Gini genes (Fisher exact test p value < 1e-18).
These differences in success rates were highly significant (adjusted P value <10 −18 ) ( SI Appendix , Fig.
The signaling events mediated by HDAC Class III was highly significant at the p < 0.01 × 10 −16 level as was the glucocorticoid receptor regulatory network at the p < 0.01 × 10 −6 level.
The results as shown in Table 1 revealed highly significant differences ( p < 10 −18 ) for all six measured metrics, including Avg_Area, Avg_Migration, Avg_Motility, Avg_Irregularity, Avg_Directness, and Avg_Optical_Thickness.
Remarkably however, 79 of the CF-Meta enriched gene sets were also enriched in the CFG analysis, which was highly significant (Fisher’s exact p < 1e − 18).
Language Related to Self-experience Could Infer Clinical Symptoms CCA conducted in the training sample revealed a highly significant relationship between language features and the PANSS ( r = .62, P < 10 −18 ; figure 3A ), and those linear combinations of the PANSS subscales and language factors were validated in the testing set ( r = .59, P < 10 −6 ; 3B).
Tests for Neotoma species ( Figure 1 ) were also highly significant ( N. albigula p<10 -18 , N. goldmani p<10 -16 , N. lepida p<10 -11 , N. mexicana p<10 -5 , N. micropus p<10 -13 , and N. phenax p<10 -73 ); some areas of overprediction (e.g., N. mexicana in the Yucatan Peninsula) represent either prediction into areas not inhabited for historic reasons (18) or true overprediction error.